Functional imaging and targeted drug delivery in mice and patient tumors with a cell nucleolus-localizing and tumor-targeting peptide DOI Creative Commons

Renwei Jing,

Qian Wang, Lu Chen

et al.

Research Square (Research Square), Journal Year: 2022, Volume and Issue: unknown

Published: April 21, 2022

Abstract Tumor-targeting peptides have profound clinical implications in early detection and delineation of microscopic lesions for surgical resection, also delivery therapeutics with reduced systemic toxicity. Here, we demonstrate that a peptide (RS), selected from rationally-designed variant library reported hepatocellular carcinoma (HCC)-targeting P47, enables discrimination HCC noncancerous tissues orthotopic mice patient biopsies, micrometastases lung, up to 21-fold contrast between tumor surrounding liver, significantly higher than P47. Importantly, RS targets non-small cell lung (NSCLC) colon cancers selectivity highly proliferative nodules. Moreover, localizes nucleoli HCC, NSCLC, breast, cervical cancer cells induces nucleolar stress when conjugated chemotherapeutic Oxaliplatin (OXA) (RS-OXA), demonstrating both cellular subcellular targeting. RS-delivered OXA elicits significant retardation markedly toxicity compared alone. Injection fluorescence-labeled dynamic visualization growth RS-OXA-treated subcutaneous mice. Our study demonstrates spectrum tumors nucleolus, functional imaging targeted mice, thus provides versatile tool therapeutics.

Language: Английский

Hepatocellular Carcinoma DOI

Previn Ganesan,

Laura Kulik

Clinics in Liver Disease, Journal Year: 2022, Volume and Issue: 27(1), P. 85 - 102

Published: Oct. 18, 2022

Language: Английский

Citations

281
Targeted contrast agents and activatable probes for photoacoustic imaging of cancer DOI
Zhenxiang Zhao, Chelsea B. Swartchick, Jefferson Chan

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(3), P. 829 - 868

Published: Jan. 1, 2022

Photoacoustic (PA) imaging has emerged as a powerful technique for the high resolution visualization of biological processes within deep tissue. Through development and application exogenous targeted contrast agents activatable probes that can respond to given cancer biomarker, researchers image molecular events

Language: Английский

Citations

93
Second Near‐Infrared Plasmonic Nanomaterials for Photoacoustic Imaging and Photothermal Therapy DOI Open Access

Tingjun Yan,

Mengyao Su,

Zhimin Wang

et al.

Small, Journal Year: 2023, Volume and Issue: 19(30)

Published: April 14, 2023

Abstract Photoacoustic imaging (PAI) and imaging‐guided photothermal therapy (PTT) in the second near‐infrared window (NIR‐II, 1000–1700 nm) have received increasing attention owing to their advantages of greater penetration depth higher signal‐to‐noise ratio. Plasmonic nanomaterials with tunable optical properties strong light absorption provide an alternative dye molecules, showing great prospects for phototheranostic applications. In this review, research progress principally modulating plasmonic nanomaterials, especially affecting parameters such as size, morphology, surface chemical modification, is introduced. The commonly used NIR‐II window, including noble metals, semiconductors, heterostructures, are then summarized. addition, biomedical applications these PAI PTT phototheranostics highlighted. Finally, perspectives challenges advancing practical use clinical translation discussed.

Language: Английский

Citations

43
Organic Semiconducting Luminophores for Near‐Infrared Afterglow, Chemiluminescence, and Bioluminescence Imaging DOI
Xiaozhen Li, Chao Yin, Si Si Liew

et al.

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(46)

Published: Aug. 6, 2021

Abstract Optical imaging has played a pivotal role in deciphering vivo bioinformatics but is limited by shallow penetration depth and poor performance owing to interfering tissue autofluorescence induced concurrent photoexcitation. The emergence of near‐infrared (NIR) self‐luminescence independent real‐time irradiation timely addressed these problems. There are two main kinds self‐luminescent agents, namely inorganic organic luminophores. Inorganic luminophores usually suffer from long‐term biotoxicity concerns resulting potential heavy‐metal ions leakage nonbiodegradability, which hinders their further translational application. In contrast, luminophores, especially semiconducting (OSLs) with good biodegradable potential, tunable design, outstanding optical properties, preferred biological applications. This review summarizes the recent progress OSLs used NIR afterglow, chemiluminescence, bioluminescence imaging. Molecular manipulation nanoengineering approaches discussed, emphasis on strategies that can extend emission wavelength visible range amplify luminescence signals. concludes discussion current challenges possible solutions field.

Language: Английский

Citations

84
Combination of Ablation and Immunotherapy for Hepatocellular Carcinoma: Where We Are and Where to Go DOI Creative Commons
Kunpeng Wang,

Cong Wang,

Hao Jiang

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Dec. 15, 2021

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide and increasing in incidence. Local ablative therapy plays a role HCC treatment. Radiofrequency (RFA) one first-line therapies for early local ablation. Other ablation techniques (e.g., microwave ablation, cryoablation, irreversible electroporation, phototherapy.) have been extensively explored clinical trials or cell/animal studies but not yet established as standard treatment applied clinically. On hand, single may meet needs. other can stimulate systemic immune effects. The combination strategy immunotherapy reasonable. In this review, we briefly summarized current status progress HCC. effects strategies therapy, especially synergistic based on biomedical materials, were discussed. This review hoped to provide references future researches arrive promising new era

Language: Английский

Citations

63
Nanophotonic-enhanced photoacoustic imaging for brain tumor detection DOI Creative Commons

Ali Rizwan,

Badrinathan Sridharan,

Jin Hyeong Park

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 5, 2025

Photoacoustic brain imaging (PABI) has emerged as a promising biomedical modality, combining high contrast of optical with deep tissue penetration ultrasound imaging. This review explores the application photoacoustic in tumor imaging, highlighting synergy between nanomaterials and state art techniques to achieve high-resolution deeper tissues. PABI leverages effect, where absorbed light energy causes thermoelastic expansion, generating waves that are detected converted into images. technique enables precise diagnosis, therapy monitoring, enhanced clinical screening, specifically management complex diseases such breast cancer, lymphatic disorder, neurological conditions. Despite integration agents radiation, providing comprehensive overview current methodologies, major obstacles treatment, future directions for improving diagnostic therapeutic outcomes. The underscores significance robust research tool medical method, potential revolutionize disease diagnosis treatment.

Language: Английский

Citations

1
Functional photoacoustic microscopy of hemodynamics: a review DOI
Chao Liu, Lidai Wang

Biomedical Engineering Letters, Journal Year: 2022, Volume and Issue: 12(2), P. 97 - 124

Published: April 10, 2022

Language: Английский

Citations

35
MRI-Based Multifunctional Nanoliposomes for Enhanced HCC Therapy and Diagnosis DOI
Jingxin Sun, Zhehao Jin, Yong Jun Jin

et al.

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

The morbidity and mortality rates of hepatocellular carcinoma (HCC) are high continue to increase. antitumor effects single therapies limited because tumor heterogeneity drug resistance, the lack real-time monitoring progression during treatment process leads poor therapeutic outcomes. Therefore, novel nanodelivery platforms combining therapy diagnosis have garnered extensive attention. In this study, we developed a multifunctional vector, LPSD-DOX/siRNA, which was loaded with oleic acid-modified superparamagnetic iron oxide nanoparticles (OA-SPION) doxorubicin (DOX), further modified by DOTAP carry small interfering RNA targeting phosphatidylinositol proteoglycan-3 (Glypican-3, GPC3) (siRNA-GPC3). These components were utilized for combined HCC magnetic resonance imaging. LPSD-DOX/siRNA exhibited loading, gene transfection efficiency, low toxicity. Pharmacokinetic in vivo distribution experiments showed that significantly prolonged circulation time DOX enhanced accumulation at site. Magnetic imaging demonstrated can serve as T2 contrast agent enhance between site other tissues facilitate tissues. Antitumor revealed promoted inhibiting expression GPC3 protein HepG2 cell-transplanted tumors, increased apoptosis. conclusion, serves promising strategy combination HCC, significant potential therapy.

Language: Английский

Citations

0
Biomimetic Co‐delivery of Lenvatinib and FePt Nanoparticles for Enhanced Ferroptosis/Apoptosis Treatment of Hepatocellular Carcinoma DOI Creative Commons

Feichao Xuan,

Xingyang Zhao,

Weiran Pang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Lenvatinib, endorse as a first-line targeted therapy, has demonstrated efficacy in extending the survival span of individuals afflicted with advanced Hepatocellular carcinoma (HCC). However, its therapeutic effect wears off time, which is ascribed to cancer cell's tendency evade and tamper usual modes action, severely limiting clinical use. This study devises an innovative modality involving synergistic co-delivery FePt nanoparticles (NPs) Lenvatinib via poly lactic-co-glycolic acid (PLGA) NPs encase HCC cell membranes (Len/FePt@CMP NPs). The investigation explores mechanism through induces ferroptosis HCC, notably by dampening glutathione peroxidase 4 (GPX4) inhibition fibroblast growth factor receptor 4. are engineered enhance apoptosis for treatment. Concurrently, incorporation membrane facilitates accumulation at tumor site, leveraging mechanisms immune evasion homologous targeting. enhances ferroptosis/apoptosis treatment efficacy, triggeres Len/FePt@CMP NPs, convincingly both vitro vivo. proposed approach potential redefine paradigms overcoming mono-therapeutic limitations current treatments, showcasing improved comprehensive strategy.

Language: Английский

Citations

0
Video-Rate Dual-Modal Wide-Beam Harmonic Ultrasound and Photoacoustic Computed Tomography DOI
Yachao Zhang, Yue Wang, Puxiang Lai

et al.

IEEE Transactions on Medical Imaging, Journal Year: 2021, Volume and Issue: 41(3), P. 727 - 736

Published: Oct. 25, 2021

Dual-modal ultrasound (US) and photoacoustic (PA) imaging has tremendous advantages in biomedical applications, such as pharmacokinetics, cancer screening, imaging-guided therapy. Compared with ring-shaped arrays, a linear piezoelectric transducer array applies to more anatomical sites been widely used US/PA imaging. However, the may limit quality due narrow bandwidth, partial detection view, or sparse spatial sampling. To meet clinic demand of high-quality transducer, we develop dual-modal wide-beam harmonic (WBHUS) computed tomography at video rate. The US employs pulse phase inversion reduce clutters improve resolution. Wide-beam transmission can shorten scanning times by 267% enables 20-Hz rate, which minimize motion artifacts in vivo does not only provide accurate references for locating PA features but also reduces images. improved image allows us acquire high-resolution structures deep tissue without labeling. fast-imaging speed visualizing interventional procedures monitoring pulsations thoracic aorta radial artery real-time. video-rate single-shot use clinical-grade linear-array thus be readily implemented clinical

Language: Английский

Citations

24