Bioactive inorganic particles‐based biomaterials for skin tissue engineering

Exploration, Journal Year: 2022, Volume and Issue: 2(5)

Published: March 17, 2022

The challenge for treatment of severe cutaneous wound poses an urgent clinical need the development biomaterials to promote skin regeneration. In past few decades, introduction inorganic components into material system has become a promising strategy improving performances in process tissue repair. this review, we provide current overview bioactive particles-based used engineering. We highlight three stages evolution applied management, including single materials, inorganic/organic composite and cell-encapsulated living systems. At every stage, primary types are described, followed by citation related representative studies completed recent years. Then offer brief exposition typical approaches construct systems with incorporation healing. Finally, conclusions future directions suggested novel field

Language: Английский

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Synthesis, bioactive properties, and biomedical applications of intrinsically therapeutic nanoparticles for disease treatment

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 435, P. 134970 - 134970

Published: Feb. 1, 2022

Language: Английский

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Mesoporous Bioactive Glasses in Cancer Diagnosis and Therapy: Stimuli‐Responsive, Toxicity, Immunogenicity, and Clinical Translation

Advanced Science, Journal Year: 2021, Volume and Issue: 9(2)

Published: Nov. 19, 2021

Cancer is one of the top life-threatening dangers to human survival, accounting for over 10 million deaths per year. Bioactive glasses have developed dramatically since their discovery 50 years ago, with applications that include therapeutics as well diagnostics. A new system within bioactive glass family, mesoporous (MBGs), has evolved into a multifunctional platform, thanks MBGs easy-to-functionalize nature and tailorable textural properties-surface area, pore size, volume. Although yet meet potential in tumor treatment imaging practice, recently research shed light on distinguished capabilities promising theranostic systems cancer therapy. This review presents progress field MBG diagnosis therapy, including synthesis MBGs, mechanistic overview application drug monitoring, therapy ( particularly, targeted delivery stimuli-responsive nanoplatforms), immunological profile MBG-based nanodevices reference development novel therapeutics.

Language: Английский

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Trends and perspectives on the commercialization of bioactive glasses

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 160, P. 14 - 31

Published: Feb. 16, 2023

Language: Английский

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Ultrasound-triggered biomimetic ultrashort peptide nanofiber hydrogels promote bone regeneration by modulating macrophage and the osteogenic immune microenvironment

Bioactive Materials, Journal Year: 2023, Volume and Issue: 31, P. 231 - 246

Published: Aug. 14, 2023

The immune microenvironment plays a vital role in bone defect repair. To create an that promotes osteogenesis, researchers are exploring ways to enhance the differentiation of M2-type macrophages. Functional peptides have been discovered effectively improve this process, but they limited by low efficiency and rapid degradation

Language: Английский

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Biomineralization inspired 3D printed bioactive glass nanocomposite scaffolds orchestrate diabetic bone regeneration by remodeling micromilieu

Bioactive Materials, Journal Year: 2023, Volume and Issue: 25, P. 239 - 255

Published: Feb. 8, 2023

Type II diabetes mellitus (TIIDM) remains a challenging clinical issue for both dentists and orthopedists. By virtue of persistent hyperglycemia altered host metabolism, the pathologic diabetic micromilieu with chronic inflammation, advanced glycation end products accumulation, attenuated biomineralization severely impairs bone regeneration efficiency. Aiming to "remodel" micromilieu, we 3D-printed bioscaffolds composed Sr-containing mesoporous bioactive glass nanoparticles (Sr-MBGNs) gelatin methacrylate (GelMA). Sr-MBGNs act as precursor embedded in GelMA-simulated extracellular matrix release Sr, Ca, Si ions enhancing osteogenic, angiogenic, immunomodulatory properties. In addition angiogenic anti-inflammatory outcomes, this innovative design reveals that nanocomposites can modulate reconstruction simulate by activating lysyl oxidase form healthy enzymatic crosslinked collagen, promoting cell focal adhesion, modulating osteoblast differentiation, boosting OCN, noncollagenous proteins (intrafibrillar mineralization dependent), thus orchestrating osteogenesis through Kindlin-2/PTH1R/OCN axis. This bioscaffold provides multifunctional biomineralization-inspired system remodels "barren" microenvironment sheds light on new approaches TIIDM.

Language: Английский

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Piezoelectric hydrogel for treatment of periodontitis through bioenergetic activation

Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 346 - 361

Published: Feb. 14, 2024

The impaired differentiation ability of resident cells and disordered immune microenvironment in periodontitis pose a huge challenge for bone regeneration. Herein, we construct piezoelectric hydrogel to rescue the osteogenic capability rebuild regenerative through bioenergetic activation. Under local mechanical stress, generated piezopotential that initiates inflammatory periodontal ligament stem (PDLSCs) via modulating energy metabolism promoting adenosine triphosphate (ATP) synthesis. Moreover, it also reshapes an anti-inflammatory pro-regenerative niche switching M1 macrophages M2 phenotype. synergy tilapia gelatin stimulation enhances situ regeneration defects rats. These findings pave new pathway treating other immune-related stimulation-enabled modulation immunomodulation.

Language: Английский

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Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(3), P. 1167 - 1315

Published: Jan. 1, 2024

Silicon-based biomaterials have been extensively developed in the past decades. The classification, characteristics, multi-dimensional design, and biomedical applications of silicon-containing are comprehensively elaborated.

Language: Английский

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Immunomodulatory multicellular scaffolds for tendon-to-bone regeneration

Science Advances, Journal Year: 2024, Volume and Issue: 10(10)

Published: March 8, 2024

Limited motor activity due to the loss of natural structure impedes recovery in patients suffering from tendon-to-bone injury. Conventional biomaterials focus on strengthening regenerative ability tendons/bones restore structure. However, owing ignoring immune environment and lack multi-tissue function, satisfactory outcomes remain elusive. Here, combined manganese silicate (MS) nanoparticles with tendon/bone-related cells, immunomodulatory multicellular scaffolds were fabricated for integrated regeneration tendon-to-bone. Notably, by integrating biomimetic cellular distribution MS nanoparticles, exhibited diverse bioactivities. Moreover, enhanced specific differentiation via regulating macrophages, which was mainly attributed secretion PGE2 macrophages induced Mn ions. Furthermore, three animal results indicated that achieved immunomodulation, regeneration, function at interfaces. Thus, based inorganic offer an innovative concept immunomodulation soft/hard tissue

Language: Английский

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Piezoelectric stimulation enhances bone regeneration in alveolar bone defects through metabolic reprogramming of macrophages

Exploration, Journal Year: 2024, Volume and Issue: 4(6)

Published: June 10, 2024

Abstract Immunomodulation has emerged as a promising strategy for promoting bone regeneration. However, designing osteoimmunomodulatory biomaterial that can respond to mechanical stress in the unique microenvironment of alveolar under continuous occlusal remains significant challenge. Herein, wireless piezoelectric stimulation system, namely, hydrogel incorporating BaTiO 3 nanoparticles (BTO NPs), is successfully developed generate potentials modulating macrophage reprogramming. The reprograms macrophages towards M2 phenotype, which subsequently induces osteogenic differentiation marrow mesenchymal stem cells (BMSCs). RNA sequencing analysis reveals piezoelectricity‐modulated polarization closely associated with metabolic reprogramming, including increased amino acid biosynthesis and fatty oxidation. composite excellent biocompatibility exhibits immunomodulatory osteoinductive activities. In rat model defects, effectively promotes endogenous regeneration at load‐bearing sites. piezoelectric‐driven osteoimmunomodulation proposed this study not only broadens understanding mechanism underlying biomaterials tissue but also provides new insights into design development next‐generation biomaterials.

Language: Английский

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