Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 469, P. 143892 - 143892
Published: June 4, 2023
Language: Английский
Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)
Published: Feb. 9, 2023
Currently, the clinical treatment of critical bone defects attributed to various causes remains a great challenge, and repairing these with synthetic substitutes is most common strategy. In general, tissue engineering materials that mimic structural, mechanical biological properties natural have been extensively applied fill promote in situ regeneration. Hydrogels extracellular matrix (ECM)-like are materials, among which methacrylate-based gelatin (GelMA) hydrogels widely used because their tunable properties, excellent photocrosslinking capability good biocompatibility. Owing lack osteogenic activity, however, GelMA combined other types activities improve current composites. There three main aspects consider when enhancing regenerative performance composite materials: osteoconductivity, vascularization osteoinduction. Bioceramics, bioglass, biomimetic scaffolds, inorganic ions, bionic periosteum, growth factors two-dimensional (2D) nanomaterials combinations achieve enhanced regeneration activities. Three-dimensional (3D)-bioprinted scaffolds popular research topic (BTE), printed customized suitable for restoring large irregular due shape structural tunability, Herein, recent progress on GelMA-based hydrogel as multifunctional platforms plastic or orthopedic clinics systematically reviewed summarized. These strategies pave way design effective reconstruction biosafety. This review provides novel insights into development trends (BTE) correcting defects, contents summarized emphasized from perspectives (osteoconductivity, vascularization, osteoinduction 3D-bioprinting). addition, advantages deficiencies put forward, corresponding improvement measures presented prior application near future (created BioRender.com).
Language: Английский
Citations
83
Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 346 - 373
Published: May 9, 2024
Gelatin methacryloyl (GelMA) hydrogels is a widely used bioink because of its good biological properties and tunable physicochemical properties, which has been in variety tissue engineering regeneration. However, pure GelMA limited by the weak mechanical strength lack continuous osteogenic induction environment, difficult to meet needs bone repair. Moreover, are unable respond complex stimuli therefore adapt physiological pathological microenvironments. This review focused on functionalization strategies hydrogel based bioinks for The synthesis process was described details, various functional methods requirements regeneration, including strength, porosity, vascularization, differentiation, immunoregulation patient specific repair, etc. In addition, response smart GelMA-based external physical stimulation internal microenvironment stimulation, as well achieve both disease treatment regeneration presence common diseases (such inflammation, infection, tumor) also briefly reviewed. Finally, we emphasized current challenges possible exploration directions
Language: Английский
Citations
34
Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(4), P. 2156 - 2221
Published: March 20, 2024
Tissue engineering for injured tissue replacement and regeneration has been a subject of investigation over the last 30 years, there considerable interest in using additive manufacturing to achieve these goals. Despite such efforts, many key questions remain unanswered, particularly area biomaterial selection applications as well quantitative understanding process science. The strategic utilization biological macromolecules provides versatile approach meet diverse requirements 3D printing, printability, buildability, biocompatibility. These molecules play pivotal role both physical chemical cross-linking processes throughout biofabrication, contributing significantly overall success printing process. Among several bioprintable materials, gelatin methacryloyl (GelMA) widely utilized applications, with some degree success. In this context, review will discuss bioengineering approaches identify gelation strategies that are appropriate control rheology, buildability inks. This focus on GelMA structural (scaffold) different tissues potential carrier vehicle transport living cells their maintenance viability physiological system. Recognizing importance printability toward shape fidelity biophysical properties, major qualitative impact factors, including microrheological, viscoelastic, gelation, shear thinning properties inks, parameters, particular, reference extrusion GelMA-based Specifically, we emphasize possibilities regulate mechanical, swelling, biodegradation, cellular functionalities bio(material) by hybridization techniques, synthetic natural biopolymers, inorganic nanofillers, microcarriers. At close, possibility integration experimental data sets artificial intelligence/machine learning is emphasized predict fidelity, or inks clinically relevant tissues.
Language: Английский
Citations
23
Nanomaterials, Journal Year: 2024, Volume and Issue: 14(6), P. 531 - 531
Published: March 16, 2024
Biomimetic scaffolds imitate native tissue and can take a multidimensional form. They are biocompatible influence cellular metabolism, making them attractive bioengineering platforms. The use of biomimetic adds complexity to traditional cell cultivation methods. most commonly used technique involves cultivating cells on flat surface in two-dimensional format due its simplicity. A three-dimensional (3D) provide microenvironment for surrounding cells. There two main techniques obtaining 3D structures based the presence scaffolding. Scaffold-free consist spheroid technologies. Meanwhile, scaffold contain organoids all constructs that various types scaffolds, ranging from decellularized extracellular matrix (dECM) through hydrogels one extensively studied forms potential culture up 4D bioprinted biomaterials. bioprinting is important create scaffolds. versatility this allows many different inks, mainly hydrogels, as well inorganic substances. Increasing amounts data evidence vast usage engineering personalized medicine, with area application being regeneration skin musculoskeletal systems. Recent papers also indicate increasing vivo tests products which further strengthen importance branch emphasize need extensive research safe humansbiomimetic tissues organs. In review article, we recent advancements field preceded by an overview technologies led development complex type culture.
Language: Английский
Citations
22
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: July 16, 2024
Bioactive glass (BG) is a class of biocompatible, biodegradable, multifunctional inorganic materials, which successfully used for orthopedic and dental applications, with several products already approved clinical use. Apart from exhibiting osteogenic properties, BG also known to be angiogenic antibacterial. Recently, BG's role in immunomodulation has been gradually revealed. While the therapeutic effect mostly reported context bone skin-related regeneration, its application regenerating other tissues/organs, such as muscle, cartilage, gastrointestinal tissue, explored recently. The strategies applying have expanded powder or cement form more advanced fabrication composite polymer-BG scaffold, 3D printing BG-loaded BG-induced extracellular vesicle production. This review presents concise overview recent applications regenerative medicine. Various will first introduced. Next, various bone, tendon, skin, discussed. Finally, summarizing tissue regeneration conclude, outline future challenges directions translation BG.
Language: Английский
Citations
19
Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 274, P. 111282 - 111282
Published: Feb. 5, 2024
Language: Английский
Citations
17
Engineered Regeneration, Journal Year: 2023, Volume and Issue: 5(1), P. 21 - 44
Published: Oct. 27, 2023
Bone fractures are common occurrence in clinical settings, creating a high demand for effective repair material. Unfortunately, limited graft availability, donor site morbidities, unpredictable outcomes, immunologic reactions, infection risks, and geometrical mismatching concerns hampered tissue use underscored the need scaffolds more bone reconstructions due to their tunable properties. Significant progress has been carried out past decade fields of nanoceramics synthesis, bioconjugate chemistry, composite material processing. This review outlines hierarchical structures biology tissue, materialistic components (bioceramics, polymers, bioactive drugs), featured scaffolding strategies (nanofibers, hydrogels, aerogels, bioprinting, fiber-reinforced composite), emphasis that physiochemical characteristics should be used as an inspiration scaffold design. discussed how differences materiobiological aspects scaffolds, such polymer/bioceramic nanocomposite, mineralized matrix-rich 3D microenvironmental cues, pore space mechanical usage physical stimulation (magnetic, electroactive, photoactivated cues), surface cues (wettability, roughness, textured, charge), biointerface (cell–biomaterial interactions, cell-selective homing, cell regulatory strategies) modulate cellular biological response engineering. study further challenges benefits integrating
Language: Английский
Citations
32
Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 650, P. 1371 - 1381
Published: July 12, 2023
Current design strategies for biomedical tissue scaffolds are focused on multifunctionality to provide beneficial microenvironments support growth. We have developed a simple yet effective approach create core-shell fibers of poly(3-hydroxybuty-rate-co-3-hydroxyvalerate) (PHBV), which homogenously covered with titanium dioxide (TiO2) nanoparticles. Unlike the blend process, co-axial electrospinning enabled uniform distribution nanoparticles without formation large aggregates. observed 5 orders magnitude reduction in Escherichia coli survival after contact electrospun compared non-material control. In addition, our hybrid cores-shell structure supported significantly higher osteoblast proliferation 7 days cell culture and profound generation 3D networked collagen 14 days. The organic-inorganic composite scaffold produced this study demonstrates unique combination antibacterial properties increased bone regeneration properties. summary, presented cPHBV+sTiO2 shows great promise applications.
Language: Английский
Citations
25
Materials Today Bio, Journal Year: 2023, Volume and Issue: 22, P. 100749 - 100749
Published: July 26, 2023
Facilitating regeneration of the tendon-to-bone interface can reduce risk postoperative retear after rotator cuff repair. Unfortunately, undesirable inflammatory responses following injury, difficulties in fibrocartilage regeneration, and bone loss surrounding area are major contributors to suboptimal tendon-bone healing. Thus, development biomaterials capable regulating macrophage polarization a favorable phenotype promoting synchronous is currently top priority. Here, strontium-doped mesoporous bioglass nanoparticles (Sr-MBG) were synthesized through modulated sol-gel method Bi-lineage Inducible Immunoregulatory Electrospun Fibers Scaffolds (BIIEFS) containing Sr-MBG fabricated. The BIIEFS biocompatible, showed sustained release multiple types bioactive ions, enhanced osteogenic chondrogenic differentiation mesenchymal stem cells (MSCs), facilitated towards M2 vitro. implantation at torn resulted greater numbers macrophages tendon, fibrocartilage, interface, leading significant improvement biomechanical strength supraspinatus tendon-humerus complexes. Our research offers feasible strategy fabricate immunoregulatory multi-lineage inducible electrospun fibers scaffolds incorporating for soft-to-hard tissue interfaces.
Language: Английский
Citations
25
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 332, P. 121945 - 121945
Published: Feb. 13, 2024
Language: Английский
Citations
13