Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 283, P. 111673 - 111673
Published: July 3, 2024
Language: Английский
Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 308, P. 120647 - 120647
Published: Feb. 3, 2023
Language: Английский
Citations
82
Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)
Published: Feb. 9, 2023
Currently, the clinical treatment of critical bone defects attributed to various causes remains a great challenge, and repairing these with synthetic substitutes is most common strategy. In general, tissue engineering materials that mimic structural, mechanical biological properties natural have been extensively applied fill promote in situ regeneration. Hydrogels extracellular matrix (ECM)-like are materials, among which methacrylate-based gelatin (GelMA) hydrogels widely used because their tunable properties, excellent photocrosslinking capability good biocompatibility. Owing lack osteogenic activity, however, GelMA combined other types activities improve current composites. There three main aspects consider when enhancing regenerative performance composite materials: osteoconductivity, vascularization osteoinduction. Bioceramics, bioglass, biomimetic scaffolds, inorganic ions, bionic periosteum, growth factors two-dimensional (2D) nanomaterials combinations achieve enhanced regeneration activities. Three-dimensional (3D)-bioprinted scaffolds popular research topic (BTE), printed customized suitable for restoring large irregular due shape structural tunability, Herein, recent progress on GelMA-based hydrogel as multifunctional platforms plastic or orthopedic clinics systematically reviewed summarized. These strategies pave way design effective reconstruction biosafety. This review provides novel insights into development trends (BTE) correcting defects, contents summarized emphasized from perspectives (osteoconductivity, vascularization, osteoinduction 3D-bioprinting). addition, advantages deficiencies put forward, corresponding improvement measures presented prior application near future (created BioRender.com).
Language: Английский
Citations
79
Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100569 - 100569
Published: Feb. 1, 2023
The key to critical bone regeneration in tissue engineering relies on an ideal bio-scaffold coated with a controlled release of growth factors. Gelatin methacrylate (GelMA) and Hyaluronic acid (HAMA) have been novel topic interest while introducing appropriate nano-hydroxyapatite (nHAP) improve its mechanical properties. And the exosomes derived from human urine-derived stem cells (human USCEXOs) also reported promote osteogenesis engineering. present study aimed design new GelMA-HAMA/nHAP composite hydrogel as drug delivery system. USCEXOs were encapsulated slow-released for better osteogenesis. characterization GelMA-based showed excellent performance vitro studies that USCEXOs/GelMA-HAMA/nHAP could marrow mesenchymal (BMSCs) angiogenesis endothelial progenitor (EPCs), respectively. Meanwhile, vivo results confirmed this significantly defect repair cranial rat model. In addition, we found can formation H-type vessels area, enhancing therapeutic effect. conclusion, our findings suggested controllable biocompatible may effectively by coupling angiogenesis.
Language: Английский
Citations
55
Advanced Science, Journal Year: 2023, Volume and Issue: 11(1)
Published: Nov. 20, 2023
Abstract Deregulated inflammations induced by various factors are one of the most common diseases in people's daily life, while severe inflammation can even lead to death. Thus, efficient treatment has always been hot topic research medicine. In past decades, as a potential biomaterial, stimuli‐responsive hydrogels have focus attention for due their excellent biocompatibility and design flexibility. Recently, thanks rapid development nanotechnology material science, more efforts made develop safer, personal effective therapy some frequent but tough such sepsis, rheumatoid arthritis, osteoarthritis, periodontitis, ulcerative colitis. Herein, from recent studies articles, conventional emerging delivery anti‐inflammatory drugs summarized. And prospects clinical translation future also discussed further detail.
Language: Английский
Citations
49
Small Methods, Journal Year: 2023, Volume and Issue: 8(3)
Published: Nov. 23, 2023
Abstract Zeolite imidazole framework‐8 (ZIF‐8) is the most prestigious one among zeolitic imidazolate framework (ZIF) with tunable dimensions and unique morphological features. Utilizing its synthetic adjustability structural regularity, ZIF‐8 exhibits enhanced flexibility, allowing for a wide range of functionalities, such as loading nanoparticle components while preserving biomolecules activity. Extensive efforts are made from investigating synthesis techniques to develop novel applications over decades. In this review, development recent progress various approaches briefly summarized. addition, interesting properties adjustable porosity, excellent thermal, chemical stabilities introduced. Further, five representative biomedical highlighted based on above physicochemical properties. Finally, remaining challenges offered insights into future outlook also discussed. This review aims understand co‐relationships between structures offering opportunity construct attractive materials promising characteristics.
Language: Английский
Citations
42
Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 346 - 373
Published: May 9, 2024
Gelatin methacryloyl (GelMA) hydrogels is a widely used bioink because of its good biological properties and tunable physicochemical properties, which has been in variety tissue engineering regeneration. However, pure GelMA limited by the weak mechanical strength lack continuous osteogenic induction environment, difficult to meet needs bone repair. Moreover, are unable respond complex stimuli therefore adapt physiological pathological microenvironments. This review focused on functionalization strategies hydrogel based bioinks for The synthesis process was described details, various functional methods requirements regeneration, including strength, porosity, vascularization, differentiation, immunoregulation patient specific repair, etc. In addition, response smart GelMA-based external physical stimulation internal microenvironment stimulation, as well achieve both disease treatment regeneration presence common diseases (such inflammation, infection, tumor) also briefly reviewed. Finally, we emphasized current challenges possible exploration directions
Language: Английский
Citations
30
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150641 - 150641
Published: March 26, 2024
Language: Английский
Citations
20
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Jan. 4, 2024
Abstract Periodontitis is a chronic inflammatory disease caused by the local microbiome and host immune response, resulting in periodontal structure damage even tooth loss. Scaling root planning combined with antibiotics are conventional means of nonsurgical treatment periodontitis, but they insufficient to fully heal periodontitis due intractable bacterial attachment drug resistance. Novel effective therapeutic options clinical therapy remain scarce. Nanotherapeutics achieve stable cell targeting, oral retention smart release great flexibility changing chemical composition or physical characteristics nanoparticles. Meanwhile, protectiveness high surface area volume ratio nanoparticles enable loading, ensuring remarkable efficacy. Currently, combination advanced novel strategies most active research treatment. In this review, we first introduce pathogenesis then summarize state-of-the-art nanotherapeutic based on triple concerto antibacterial activity, immunomodulation periodontium regeneration, particularly focusing mechanism ingenious design nanomedicines. Finally, challenges prospects nano for discussed from perspective current problems future development trends. Graphical
Language: Английский
Citations
19
Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 18, 2024
Hydrogels, composed of hydrophilic polymer networks, have emerged as versatile materials in biomedical applications due to their high water content, biocompatibility, and tunable properties. They mimic natural tissue environments, enhancing cell viability function. Hydrogels' physical properties allow for tailored antibacterial biomaterial, wound dressings, cancer treatment, engineering scaffolds. Their ability respond physiological stimuli enables the controlled release therapeutics, while porous structure supports nutrient diffusion waste removal, fostering regeneration repair. In healing, hydrogels provide a moist environment, promote migration, deliver bioactive agents antibiotics, healing process. For therapy, they offer localized drug delivery systems that target tumors, minimizing systemic toxicity improving therapeutic efficacy. Ocular therapy benefits from hydrogels' capacity form contact lenses maintain prolonged with eye surface, treatment outcomes various diseases. mucosal delivery, facilitate administration therapeutics across barriers, ensuring sustained improved bioavailability drugs. Tissue sees scaffolds extracellular matrix, supporting growth differentiation repairing damaged tissues. Similarly, bone regeneration, loaded factors stem cells osteogenesis accelerate healing. This article highlights some recent advances use applications, driven by be engineered specific needs interactive biological
Language: Английский
Citations
19
Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(6), P. 3217 - 3248
Published: Jan. 18, 2024
Hydrogel, as a unique scaffold material, features three-dimensional network system that provides conducive conditions for the growth of cells and tissues in bone tissue engineering (BTE). In recent years, it has been discovered metal ion-containing hybridized hydrogels, synthesized with particles foundation, exhibit excellent physicochemical properties, osteoinductivity, osteogenic potential. They offer wide range research prospects field BTE. This review an overview current state advancements concerning hydrogels Within materials science, covers topics such binding mechanisms ions within hydrogel networks, types fabrication methods various influence on properties hydrogels. context BTE, delves into ions, applications relevant experimental studies vitro vivo. Furthermore, future improvements repair can be anticipated through bionics, exploring interactions between development wider types.
Language: Английский
Citations
17