Pt(ii) metallacycles encapsulated by ferritin enable precise cancer combination chemo-photodynamic therapy DOI

Xuehong Min,

Ming Li, Wenjing Zhang

et al.

Journal of Materials Chemistry B, Journal Year: 2022, Volume and Issue: 11(5), P. 1090 - 1099

Published: Dec. 12, 2022

Different from common anti-tumor drugs, organoplatinum(II) metallacycles can integrate imaging and other therapeutic capabilities by incorporating corresponding functional donor ligands to enable potential applications in biomedicine. However, most of the emerging agents not only show poor solubility selectivity but also have serious side effects unsatisfactory efficacy encounter tendency develop drug resistance due their single treatment model. Herein, an metallacycle (PtM) was designed synthesized using coordination-driven self-assembly via combination a metallic chemotherapy precursor reactive oxygen species generating organic precursor. The hydrophobic PtM molecules were encapsulated cavity human heavy chain ferritin (HFn) during reassembly HFn prepare active targeting nanoagent HFn-PtM for use chemo-photodynamic therapy. nanoagents exhibited excellent stability buffer (pH 5 7.2), alleviating concern leakage circulation. A cellular uptake assay indicated that could efficiently enter specific cells overexpress transferrin receptor 1. In vitro vivo investigations revealed efficiency with negligible systemic toxicity. This work provides strategy easy construction multifunctional organoplatinum-based tumor-targeted drugs.

Language: Английский

Amplifying “eat me signal” by immunogenic cell death for potentiating cancer immunotherapy DOI

Yong Xi,

Lijie Chen,

Jian Tang

et al.

Immunological Reviews, Journal Year: 2023, Volume and Issue: 321(1), P. 94 - 114

Published: Aug. 7, 2023

Immunogenic cell death (ICD) is a unique mode of death, which can release immunogenic damage-associated molecular patterns (DAMPs) and tumor-associated antigens to trigger long-term protective antitumor immune responses. Thus, amplifying "eat me signal" during tumor ICD cascade critical for cancer immunotherapy. Some therapies (radiotherapy, photodynamic therapy (PDT), photothermal (PTT), etc.) inducers (chemotherapeutic agents, have enabled initiate and/or facilitate activate Recently, nanostructure-based drug delivery systems been synthesized inducing through combining treatment chemotherapeutic photosensitizers PDT, transformation agents PTT, radiosensitizers radiotherapy, etc., loaded at an appropriate dosage in the designated place time, contributing higher efficiency lower toxicity. Also, immunotherapeutic combination with produce synergetic effects, thus potentiating Overall, our review outlines emerging inducers, nanostructure loading diverse evoke chemoradiotherapy, PTT or agents. Moreover, we discuss prospects challenges harnessing induction-based immunotherapy, highlight significance multidisciplinary interprofessional collaboration promote optimal translation this strategy.

Language: Английский

Citations

45

Nanomaterial-encapsulated STING agonists for immune modulation in cancer therapy DOI Creative Commons
Xi Chen, Zhijie Xu, Tongfei Li

et al.

Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Jan. 7, 2024

Abstract The cGAS-STING signaling pathway has emerged as a critical mediator of innate immune responses, playing crucial role in improving antitumor immunity through effector responses. Targeting the holds promise for overcoming immunosuppressive tumor microenvironments (TME) and promoting effective elimination. However, systemic administration current STING agonists faces challenges related to low bioavailability potential adverse effects, thus limiting their clinical applicability. Recently, nanotechnology-based strategies have been developed modulate TMEs robust immunotherapeutic encapsulation delivery within nanoparticles (STING-NPs) present an attractive avenue immunotherapy. This review explores range designed encapsulate agonists, highlighting benefits, including favorable biocompatibility, improved penetration, efficient intracellular agonists. also summarizes immunomodulatory impacts STING-NPs on TME, enhanced secretion pro-inflammatory cytokines chemokines, dendritic cell activation, cytotoxic T priming, macrophage re-education, vasculature normalization. Furthermore, offers insights into co-delivered nanoplatforms involving alongside agents such chemotherapeutic compounds, checkpoint inhibitors, antigen peptides, other adjuvants. These platforms demonstrate remarkable versatility inducing immunogenic responses ultimately amplifying

Language: Английский

Citations

25

Ferroptosis: The Entanglement between Traditional Drugs and Nanodrugs in Tumor Therapy DOI
Kexuan Liu, Lei Huang,

Shuangyan Qi

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(12)

Published: Jan. 19, 2023

Ferroptosis is a non-apoptotic programmed cell death caused by the accumulation of lipid peroxide. System Xc-/glutathione peroxidase 4 (GPX4) axis and iron are two main pathways regulating ferroptosis. Simultaneously, multiple also involved in ferroptosis regulation. an intense area current study. With improvement regulatory mechanisms that underlie ferroptosis, variety drugs associated with have been discovered developed for cancer therapy. Among them, traditional were initially. Small molecule compounds regulate signaling pathway complexes promote Fenton reaction become important inducing In recent years, emerging development nanotechnology has promoted research nanodrugs. Iron-based nanomaterials extensively tested as ferroptosis-inducing agents. Furthermore, nanoscale drug delivery systems offer suitable scaffold therapies. Traditional nanodrugs complementary, each their own strengths limitations. This review describes latest studies on regulation tumor cells focuses entanglement between To conclude, challenges perspectives this field put forward.

Language: Английский

Citations

40

Nanoparticle‐Mediated STING Activation for Cancer Immunotherapy DOI

Yongjuan Li,

Xinyan Li,

Jinmeng Yi

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(19)

Published: March 11, 2023

Abstract As the first line of host defense against pathogenic infections, innate immunity plays a key role in antitumor immunotherapy. The cyclic GMP‐AMP synthase (cGAS)‐stimulator interferon genes (STING) (cGAS‐STING) pathway has attracted much attention because secretion various proinflammatory cytokines and chemokines. Many STING agonists have been identified applied into preclinical or clinical trials for cancer However, fast excretion, low bioavailability, nonspecificity, adverse effects small molecule limit their therapeutic efficacy vivo application. Nanodelivery systems with appropriate size, charge, surface modification are capable addressing these dilemmas. In this review, mechanism cGAS‐STING is discussed agonists, focusing on nanoparticle‐mediated therapy combined cancers, summarized. Finally, future direction challenges nano‐STING expounded, emphasizing pivotal scientific problems technical bottlenecks hoping to provide general guidance its

Language: Английский

Citations

35

Recent Advances in Reprogramming Strategy of Tumor Microenvironment for Rejuvenating Photosensitizers‐Mediated Photodynamic Therapy DOI
Qing Yu, Xia Li, Juan Wang

et al.

Small, Journal Year: 2023, Volume and Issue: 20(16)

Published: Nov. 28, 2023

Abstract Photodynamic therapy (PDT) has recently been considered a potential tumor due to its time‐space specificity and non‐invasive advantages. PDT can not only directly kill cells by using cytotoxic reactive oxygen species but also induce an anti‐tumor immune response causing immunogenic cell death of cells. Although it exhibits promising prospect in treating tumors, there are still many problems be solved practical application. Tumor hypoxia immunosuppressive microenvironment seriously affect the efficacy PDT. The hypoxic is mainly abnormal vascular matrix around tumor, metabolism, influence various immunosuppressive‐related their expressed molecules. Thus, reprogramming (TME) great significance for rejuvenating This article reviews latest strategies PDT, from regulating matrix, interfering with related factors reverse microenvironment. These provide valuable information better understanding TME guide development next‐generation multifunctional nanoplatforms

Language: Английский

Citations

26

Carbohydrate ligands-directed active tumor targeting of combinatorial chemotherapy/phototherapy-based nanomedicine: A review DOI
Mona M. Agwa, Heba Elmotasem, Hassan Elsayed

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 239, P. 124294 - 124294

Published: March 31, 2023

Language: Английский

Citations

24

Enhancing cancer immunotherapy: Nanotechnology-mediated immunotherapy overcoming immunosuppression DOI Creative Commons

Yunna Chen,

Qianqian Zhou,

Zongfang Jia

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(9), P. 3834 - 3854

Published: June 3, 2024

Immunotherapy is an important cancer treatment method that offers hope for curing patients. While immunotherapy has achieved initial success, a major obstacle to its widespread adoption the inability benefit majority of The success or failure closely linked tumor's immune microenvironment. Recently, there been significant attention on strategies regulate tumor microenvironment in order stimulate anti-tumor responses immunotherapy. distinctive physical properties and design flexibility nanomedicines have extensively utilized target cells (including tumor-associated macrophages (TAMs), T cells, myeloid-derived suppressor (MDSCs), fibroblasts (TAFs)), offering promising advancements In this article, we reviewed aimed at targeting various focus models are based nanomedicines, with goal inducing enhancing improve It worth noting combining other treatments, such as chemotherapy, radiotherapy, photodynamic therapy, can maximize therapeutic effects. Finally, identified challenges nanotechnology-mediated needs overcome more effective nanosystems.

Language: Английский

Citations

17

Single‐Component Dual‐Functional Autoboost Strategy by Dual Photodynamic and Cyclooxygenase‐2 Inhibition for Lung Cancer and Spinal Metastasis DOI Creative Commons
Ben Wang,

Zhenni Lu,

Mengxiong Song

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(12)

Published: Jan. 15, 2024

Abstract Coloading adjuvant drugs or biomacromolecules with photosensitizers into nanoparticles to enhance the efficiency of photodynamic therapy (PDT) is a common strategy. However, it difficult load positively charged and negatively adjuvants same nanomaterial further regulate drug release simultaneously. Herein, single‐component dual‐functional prodrug strategy reported for tumor treatment specifically activated by microenvironment (TME)‐generated HOCl. A representative (DHU‐CBA2) constructed using indomethacin grafted methylene blue (MB). DHU‐CBA2 exhibited high sensitivity toward HOCl achieved simultaneous dual in vitro vivo. shows effective antitumor activity against lung cancer spinal metastases via PDT cyclooxygenase‐2 (COX‐2) inhibition. Mechanistically, induces immunogenic cell death but stimulates gene encoding COX‐2. Downstream prostaglandins E 2 Indoleamine 2,3 dioxygenase 1 (IDO1) mediate immune escape TME, which rescued indomethacin. promotes infiltration function CD8 + T cells, thus inducing robust response. This work provides an autoboost TME‐specific HOCl, thereby achieving favorable synergistic COX‐2 inhibitor.

Language: Английский

Citations

9

A Self‐Amplifying Photodynamic Biomedicine for Cascade Immune Activation Against Triple‐Negative Breast Cancer DOI Open Access

Xianquan Feng,

Yan Zhang,

Wanjing Lin

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Abstract The efficacy of immunotherapy in triple‐negative breast cancer (TNBC) is significantly hindered by its low immunogenicity and immunosuppressive tumor microenvironment. Non‐invasive photodynamic therapy (PDT) increasingly recognized as a potential immunotherapeutic stimulant the treatment TNBC. However, constrained hypoxia excessive inflammation suppression during course treatment. Herein, simple efficacious biomedicine formulated to overcome adverse influences amplifying immunotherapy, thereby stimulating systemic immune response. Specifically, approach targeted delivery employing specific agents such photosensitizer (verteporfin), hypoxic ameliorator (atovaquone), cyclooxygenase‐2/prostaglandin E2 (COX‐2/PGE2) signaling blocker (celecoxib). More importantly, effectively ameliorated inhibited COX‐2/PGE2 signaling, PDT‐induced immunogenic cell death. This, turn, enhanced triggered robust response cascade. Notably, self‐amplifying primary tumors, distal lung metastases, post‐operative recurrence while maintaining high biocompatibility. To sum up, work provides viable cascade stimulation an efficient biomedical nanoplatform, offering novel strategy for TNBC clinic.

Language: Английский

Citations

1

Evaluation of Cell Proliferation and Wound Healing Effects of Vitamin A Palmitate-Loaded PLGA/Chitosan-Coated PLGA Nanoparticles: Preparation, Characterization, Release, and Release Kinetics DOI Creative Commons

Lala Baghirova,

Elif Kaya Tilki, A. Alper Öztürk

et al.

ACS Omega, Journal Year: 2023, Volume and Issue: 8(2), P. 2658 - 2668

Published: Jan. 6, 2023

In this study, vitamin A palmitate (VAP)-loaded poly(lactic-co-glycolic acid) (PLGA)/chitosan-coated PLGA nanoparticle (NP) systems were prepared by the nanoprecipitation technique. The characterized parameters such as particle size, polydispersity index (PDI), ζ-potential, encapsulation efficiency, in vitro dissolution, and release kinetic study. Then, cytotoxicity wound healing profiles of designed NP formulations HaCaT (human keratinocyte skin cell lines) determined. size VAP-loaded NPs was obtained between 196.33 ± 0.65 669.23 5.49 nm. PDI data proved that all high quality monodisperse. While negative ζ-potential values Blank-NP-1 NP-1 encoded obtained, positive chitosan-coated NPs. studies observed rapid dissolution first 1-6 h, but prolonged VAP after dissolution. As a result culture activity studies, it determined NP-7 most effective. It thought reason for coded formulation with smallest concluded efficiency increased its structure. This study demonstrated similar effects systems, particular NP-7, which increases proliferation at lower concentrations (10 μg·mL-1) than alone (100 μg·mL-1). nanocarriers can be used pharmaceutical industry have been successfully produced results evaluated promising industry.

Language: Английский

Citations

22