Journal of Materials Chemistry B,
Journal Year:
2022,
Volume and Issue:
11(5), P. 1090 - 1099
Published: Dec. 12, 2022
Different
from
common
anti-tumor
drugs,
organoplatinum(II)
metallacycles
can
integrate
imaging
and
other
therapeutic
capabilities
by
incorporating
corresponding
functional
donor
ligands
to
enable
potential
applications
in
biomedicine.
However,
most
of
the
emerging
agents
not
only
show
poor
solubility
selectivity
but
also
have
serious
side
effects
unsatisfactory
efficacy
encounter
tendency
develop
drug
resistance
due
their
single
treatment
model.
Herein,
an
metallacycle
(PtM)
was
designed
synthesized
using
coordination-driven
self-assembly
via
combination
a
metallic
chemotherapy
precursor
reactive
oxygen
species
generating
organic
precursor.
The
hydrophobic
PtM
molecules
were
encapsulated
cavity
human
heavy
chain
ferritin
(HFn)
during
reassembly
HFn
prepare
active
targeting
nanoagent
HFn-PtM
for
use
chemo-photodynamic
therapy.
nanoagents
exhibited
excellent
stability
buffer
(pH
5
7.2),
alleviating
concern
leakage
circulation.
A
cellular
uptake
assay
indicated
that
could
efficiently
enter
specific
cells
overexpress
transferrin
receptor
1.
In
vitro
vivo
investigations
revealed
efficiency
with
negligible
systemic
toxicity.
This
work
provides
strategy
easy
construction
multifunctional
organoplatinum-based
tumor-targeted
drugs.
Immunological Reviews,
Journal Year:
2023,
Volume and Issue:
321(1), P. 94 - 114
Published: Aug. 7, 2023
Immunogenic
cell
death
(ICD)
is
a
unique
mode
of
death,
which
can
release
immunogenic
damage-associated
molecular
patterns
(DAMPs)
and
tumor-associated
antigens
to
trigger
long-term
protective
antitumor
immune
responses.
Thus,
amplifying
"eat
me
signal"
during
tumor
ICD
cascade
critical
for
cancer
immunotherapy.
Some
therapies
(radiotherapy,
photodynamic
therapy
(PDT),
photothermal
(PTT),
etc.)
inducers
(chemotherapeutic
agents,
have
enabled
initiate
and/or
facilitate
activate
Recently,
nanostructure-based
drug
delivery
systems
been
synthesized
inducing
through
combining
treatment
chemotherapeutic
photosensitizers
PDT,
transformation
agents
PTT,
radiosensitizers
radiotherapy,
etc.,
loaded
at
an
appropriate
dosage
in
the
designated
place
time,
contributing
higher
efficiency
lower
toxicity.
Also,
immunotherapeutic
combination
with
produce
synergetic
effects,
thus
potentiating
Overall,
our
review
outlines
emerging
inducers,
nanostructure
loading
diverse
evoke
chemoradiotherapy,
PTT
or
agents.
Moreover,
we
discuss
prospects
challenges
harnessing
induction-based
immunotherapy,
highlight
significance
multidisciplinary
interprofessional
collaboration
promote
optimal
translation
this
strategy.
Biomarker Research,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: Jan. 7, 2024
Abstract
The
cGAS-STING
signaling
pathway
has
emerged
as
a
critical
mediator
of
innate
immune
responses,
playing
crucial
role
in
improving
antitumor
immunity
through
effector
responses.
Targeting
the
holds
promise
for
overcoming
immunosuppressive
tumor
microenvironments
(TME)
and
promoting
effective
elimination.
However,
systemic
administration
current
STING
agonists
faces
challenges
related
to
low
bioavailability
potential
adverse
effects,
thus
limiting
their
clinical
applicability.
Recently,
nanotechnology-based
strategies
have
been
developed
modulate
TMEs
robust
immunotherapeutic
encapsulation
delivery
within
nanoparticles
(STING-NPs)
present
an
attractive
avenue
immunotherapy.
This
review
explores
range
designed
encapsulate
agonists,
highlighting
benefits,
including
favorable
biocompatibility,
improved
penetration,
efficient
intracellular
agonists.
also
summarizes
immunomodulatory
impacts
STING-NPs
on
TME,
enhanced
secretion
pro-inflammatory
cytokines
chemokines,
dendritic
cell
activation,
cytotoxic
T
priming,
macrophage
re-education,
vasculature
normalization.
Furthermore,
offers
insights
into
co-delivered
nanoplatforms
involving
alongside
agents
such
chemotherapeutic
compounds,
checkpoint
inhibitors,
antigen
peptides,
other
adjuvants.
These
platforms
demonstrate
remarkable
versatility
inducing
immunogenic
responses
ultimately
amplifying
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(12)
Published: Jan. 19, 2023
Ferroptosis
is
a
non-apoptotic
programmed
cell
death
caused
by
the
accumulation
of
lipid
peroxide.
System
Xc-/glutathione
peroxidase
4
(GPX4)
axis
and
iron
are
two
main
pathways
regulating
ferroptosis.
Simultaneously,
multiple
also
involved
in
ferroptosis
regulation.
an
intense
area
current
study.
With
improvement
regulatory
mechanisms
that
underlie
ferroptosis,
variety
drugs
associated
with
have
been
discovered
developed
for
cancer
therapy.
Among
them,
traditional
were
initially.
Small
molecule
compounds
regulate
signaling
pathway
complexes
promote
Fenton
reaction
become
important
inducing
In
recent
years,
emerging
development
nanotechnology
has
promoted
research
nanodrugs.
Iron-based
nanomaterials
extensively
tested
as
ferroptosis-inducing
agents.
Furthermore,
nanoscale
drug
delivery
systems
offer
suitable
scaffold
therapies.
Traditional
nanodrugs
complementary,
each
their
own
strengths
limitations.
This
review
describes
latest
studies
on
regulation
tumor
cells
focuses
entanglement
between
To
conclude,
challenges
perspectives
this
field
put
forward.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(19)
Published: March 11, 2023
Abstract
As
the
first
line
of
host
defense
against
pathogenic
infections,
innate
immunity
plays
a
key
role
in
antitumor
immunotherapy.
The
cyclic
GMP‐AMP
synthase
(cGAS)‐stimulator
interferon
genes
(STING)
(cGAS‐STING)
pathway
has
attracted
much
attention
because
secretion
various
proinflammatory
cytokines
and
chemokines.
Many
STING
agonists
have
been
identified
applied
into
preclinical
or
clinical
trials
for
cancer
However,
fast
excretion,
low
bioavailability,
nonspecificity,
adverse
effects
small
molecule
limit
their
therapeutic
efficacy
vivo
application.
Nanodelivery
systems
with
appropriate
size,
charge,
surface
modification
are
capable
addressing
these
dilemmas.
In
this
review,
mechanism
cGAS‐STING
is
discussed
agonists,
focusing
on
nanoparticle‐mediated
therapy
combined
cancers,
summarized.
Finally,
future
direction
challenges
nano‐STING
expounded,
emphasizing
pivotal
scientific
problems
technical
bottlenecks
hoping
to
provide
general
guidance
its
Small,
Journal Year:
2023,
Volume and Issue:
20(16)
Published: Nov. 28, 2023
Abstract
Photodynamic
therapy
(PDT)
has
recently
been
considered
a
potential
tumor
due
to
its
time‐space
specificity
and
non‐invasive
advantages.
PDT
can
not
only
directly
kill
cells
by
using
cytotoxic
reactive
oxygen
species
but
also
induce
an
anti‐tumor
immune
response
causing
immunogenic
cell
death
of
cells.
Although
it
exhibits
promising
prospect
in
treating
tumors,
there
are
still
many
problems
be
solved
practical
application.
Tumor
hypoxia
immunosuppressive
microenvironment
seriously
affect
the
efficacy
PDT.
The
hypoxic
is
mainly
abnormal
vascular
matrix
around
tumor,
metabolism,
influence
various
immunosuppressive‐related
their
expressed
molecules.
Thus,
reprogramming
(TME)
great
significance
for
rejuvenating
This
article
reviews
latest
strategies
PDT,
from
regulating
matrix,
interfering
with
related
factors
reverse
microenvironment.
These
provide
valuable
information
better
understanding
TME
guide
development
next‐generation
multifunctional
nanoplatforms
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(9), P. 3834 - 3854
Published: June 3, 2024
Immunotherapy
is
an
important
cancer
treatment
method
that
offers
hope
for
curing
patients.
While
immunotherapy
has
achieved
initial
success,
a
major
obstacle
to
its
widespread
adoption
the
inability
benefit
majority
of
The
success
or
failure
closely
linked
tumor's
immune
microenvironment.
Recently,
there
been
significant
attention
on
strategies
regulate
tumor
microenvironment
in
order
stimulate
anti-tumor
responses
immunotherapy.
distinctive
physical
properties
and
design
flexibility
nanomedicines
have
extensively
utilized
target
cells
(including
tumor-associated
macrophages
(TAMs),
T
cells,
myeloid-derived
suppressor
(MDSCs),
fibroblasts
(TAFs)),
offering
promising
advancements
In
this
article,
we
reviewed
aimed
at
targeting
various
focus
models
are
based
nanomedicines,
with
goal
inducing
enhancing
improve
It
worth
noting
combining
other
treatments,
such
as
chemotherapy,
radiotherapy,
photodynamic
therapy,
can
maximize
therapeutic
effects.
Finally,
identified
challenges
nanotechnology-mediated
needs
overcome
more
effective
nanosystems.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(12)
Published: Jan. 15, 2024
Abstract
Coloading
adjuvant
drugs
or
biomacromolecules
with
photosensitizers
into
nanoparticles
to
enhance
the
efficiency
of
photodynamic
therapy
(PDT)
is
a
common
strategy.
However,
it
difficult
load
positively
charged
and
negatively
adjuvants
same
nanomaterial
further
regulate
drug
release
simultaneously.
Herein,
single‐component
dual‐functional
prodrug
strategy
reported
for
tumor
treatment
specifically
activated
by
microenvironment
(TME)‐generated
HOCl.
A
representative
(DHU‐CBA2)
constructed
using
indomethacin
grafted
methylene
blue
(MB).
DHU‐CBA2
exhibited
high
sensitivity
toward
HOCl
achieved
simultaneous
dual
in
vitro
vivo.
shows
effective
antitumor
activity
against
lung
cancer
spinal
metastases
via
PDT
cyclooxygenase‐2
(COX‐2)
inhibition.
Mechanistically,
induces
immunogenic
cell
death
but
stimulates
gene
encoding
COX‐2.
Downstream
prostaglandins
E
2
Indoleamine
2,3
dioxygenase
1
(IDO1)
mediate
immune
escape
TME,
which
rescued
indomethacin.
promotes
infiltration
function
CD8
+
T
cells,
thus
inducing
robust
response.
This
work
provides
an
autoboost
TME‐specific
HOCl,
thereby
achieving
favorable
synergistic
COX‐2
inhibitor.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(2), P. 2658 - 2668
Published: Jan. 6, 2023
In
this
study,
vitamin
A
palmitate
(VAP)-loaded
poly(lactic-co-glycolic
acid)
(PLGA)/chitosan-coated
PLGA
nanoparticle
(NP)
systems
were
prepared
by
the
nanoprecipitation
technique.
The
characterized
parameters
such
as
particle
size,
polydispersity
index
(PDI),
ζ-potential,
encapsulation
efficiency,
in
vitro
dissolution,
and
release
kinetic
study.
Then,
cytotoxicity
wound
healing
profiles
of
designed
NP
formulations
HaCaT
(human
keratinocyte
skin
cell
lines)
determined.
size
VAP-loaded
NPs
was
obtained
between
196.33
±
0.65
669.23
5.49
nm.
PDI
data
proved
that
all
high
quality
monodisperse.
While
negative
ζ-potential
values
Blank-NP-1
NP-1
encoded
obtained,
positive
chitosan-coated
NPs.
studies
observed
rapid
dissolution
first
1-6
h,
but
prolonged
VAP
after
dissolution.
As
a
result
culture
activity
studies,
it
determined
NP-7
most
effective.
It
thought
reason
for
coded
formulation
with
smallest
concluded
efficiency
increased
its
structure.
This
study
demonstrated
similar
effects
systems,
particular
NP-7,
which
increases
proliferation
at
lower
concentrations
(10
μg·mL-1)
than
alone
(100
μg·mL-1).
nanocarriers
can
be
used
pharmaceutical
industry
have
been
successfully
produced
results
evaluated
promising
industry.