Biopolymer based nanoparticles and their therapeutic potential in wound healing – A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 267, P. 131335 - 131335

Published: April 10, 2024

Language: Английский

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Preparation and characterization of Pickering emulsion gel stabilized by WPI/SPI composite particles and encapsulation of milk-derived peptide FDRPFL

LWT, Journal Year: 2024, Volume and Issue: 199, P. 116093 - 116093

Published: April 17, 2024

In this study, Pickering emulsion (PE) stabilized by whey protein isolate/soybean isolate (WPI/SPI) composite particles were used as a template to construct gel (PEG). The results showed that the PE WPI/SPI had good centrifugal and storage stability at 4 °C (at least months). Furthermore, When SA concentration was 3% PE:SA ratio of 5:1, obtained PEG with water-in-oil type exhibited smaller droplet size, denser network structure, solid-like behavior in linear viscoelastic region using laser particle size analyzer, rheometer, confocal scanning microscopy. Moreover, increase hydrogen bonds after addition confirmed increased β-sheet Fourier-transform infrared spectroscopy, structure interchain bonds, thus forming structure. addition, PEGs could effectively encapsulate peptide FDRPFL, highest encapsulation efficiency 72.8%. vitro digestion revealed improve bioaccessibility FDRPFL mainly followed release mechanism non-Fickian superstate II. Taken together, present findings provide theoretical framework for development application particles.

Language: Английский

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Evaluation of Antimicrobial Properties and Antioxidant Activity of Rosmarinic Acid-Loaded Resomer RG 502 H-Based Nanoparticles Against Tert-Butyl Hydroperoxide-Induced Oxidative Stress: A detailed formulation, characterization and efficacy determination study

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106721 - 106721

Published: Feb. 1, 2025

Language: Английский

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Platelet membrane-coated bio-nanoparticles of indocyanine green/elamipretide for NIR diagnosis and antioxidant therapy in acute kidney injury

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 173, P. 482 - 494

Published: Nov. 18, 2023

Language: Английский

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Preparation, Characterization, Antioxidant Activities, and Determination of Anti-Alzheimer Effects of PLGA-Based DDSs Containing Ferulic Acid

ACS Omega, Journal Year: 2024, Volume and Issue: 9(10), P. 11321 - 11338

Published: Feb. 29, 2024

Nanoparticle (NP) systems have attracted the attention of researchers in recent years due to their advantages, such as modified release features, increased therapeutic efficacy, and reduced side effects. Ferulic acid (FA) has effects anti-inflammatory, anti-Alzheimer's, antioxidant, antimicrobial, anticancer, antihyperlipidemic, antidiabetic. In this study, FA-loaded PLGA-based NPs were prepared by a nanoprecipitation method effect varying concentrations Poloxamer 188 Span 60 on NP properties was investigated. A-FA coded formulation chosen optimum. High encapsulation efficiency been achieved low affinity FA water phase and, therefore, its lipophilic nature, which tends migrate organic phase. It determined that from slower than pure prolonged 24 h. Antioxidant anti-Alzheimer's investigated biological activity studies. showed strong DPPH free radical scavenging, ABTS cation decolorizing, reducing antioxidant activity. Since it both AChE inhibitor according results anti-Alzheimer activity, concluded study shows promise treatment oxidative stress-related diseases Alzheimer's.

Language: Английский

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Lomefloxacin-loaded PLGA hollow nanospheres for healing MRSA-infected diabetic wound; optimization, in vitro and in vivo studies

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 100, P. 106050 - 106050

Published: Aug. 8, 2024

Language: Английский

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Multifunctional emulsion for potential wound-healing applications: A development for co-administration of essential vitamins, silver nanoparticles, and potent active ingredients

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 101, P. 106128 - 106128

Published: Aug. 29, 2024

Language: Английский

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Hypericum perforatum Oil and Vitamin A Palmitate-Loaded Gelatin Nanofibers Cross-Linked by Tannic Acid as Wound Dressings

ACS Omega, Journal Year: 2023, Volume and Issue: 8(26), P. 24023 - 24031

Published: June 26, 2023

Recent studies in wound dressing applications offer new therapies to promote the healing process. The main strategy of this study is combine traditional perspective using medicinal oils with polymeric scaffolds manufactured by an engineering approach fabricate a potential tissue product that provides both formation and healing. Thus, Hypericum perforatum oil (HPO) vitamin A palmitate (VAP) incorporated gelatin (Gt) nanofibrous were successfully prepared electrospinning method. Tannic acid (TA) was used as cross-linking agent. amounts VAP HPO loaded base Gt solution [15% w/v 4:6 v/v acetic acid/deionized water] 5 50 wt % (based on weight Gt), respectively. obtained studied regarding their microstructure, chemical structure, thermal stability, antibacterial activity, vitro release study, cellular proliferation assay. In light these studies, it determined nanofibers cross-linked TA. Release kinetic tests confirmed patterns TA consistent Higuchi model, whereas first-order model. addition, membrane biocompatible L929 fibroblast cells had activity stability. This preliminary suggests applicability proposed treat skin wounds clinics.

Language: Английский

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Natural vs Synthetic Polymers: How Do They Communicate with Cells for Skin Regeneration—A Review

Journal of Composites Science, Journal Year: 2023, Volume and Issue: 7(9), P. 385 - 385

Published: Sept. 13, 2023

Modern research has evolved several approaches toward skin regeneration and one of the novel concerns is use polymer-based systems due to their excellent beneficial properties skin. Several polymers, such as cellulose, hyaluronan, alginate, chitosan, collagen, fibrin fibroin, have been tested proven benefits for regeneration, most them are derived from either polysaccharide- or protein-based materials. In order understand mode action, researchers investigated cell–matrix interaction possible signaling mechanism in regeneration. Not only but also cell communication determines application polymers practice. Based on above significance, this review disclosed recent findings compile a method between cells polysaccharide-based (such agar, xanthan gum) gelatin, fibrin, silk fibroin) materials along with other poly(vinyl alcohol), polyglycolide poly(glycolic acid), poly(lactic acid) Accordingly, addresses fundamental concept communication, which helps us basis polymer’s functions biomedical field.

Language: Английский

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Chitosan-Coated Poly(lactic-co-glycolic acid) Nanoparticles Loaded with Ursolic Acid for Breast Cancer Therapy

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(5), P. 5383 - 5395

Published: Feb. 28, 2024

Ursolic acid (UA), a pentacyclic triterpenoid found in various fruits and herbs, has the potential as an anticancer agent against multiple cancer types. Nevertheless, its clinical use was limited by poor water solubility. To overcome this drawback, several nanocarriers were proposed to increase bioavailability efficacy of UA. However, insights into cellular targets mechanisms UA nanoparticles (NPs) remain limited. In study, chitosan-coated poly(lactic-co-glycolic acid) (PLGA/CS) NPs loaded with The obtained (UA)-PLGA/CS spherical approximate size 250 nm encapsulation efficiency 25%. Owing their promising drug carriers, successfully delivered breast cells (MCF-7 MDA-MB-231). Moreover, enhanced activity UA, evidenced IC50 values 26.74 40.67 μM MCF-7 MDA-MB-231 cells, respectively. These lower than those free (90.25 85.63 respectively). improved cytotoxicity induced can be attributed apoptosis induction, collective cell migration invasion inhibition, proliferation pathway disruption. findings led better understanding effects molecular for therapy.

Language: Английский

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