Pt(ii) metallacycles encapsulated by ferritin enable precise cancer combination chemo-photodynamic therapy DOI

Xuehong Min,

Ming Li, Wenjing Zhang

et al.

Journal of Materials Chemistry B, Journal Year: 2022, Volume and Issue: 11(5), P. 1090 - 1099

Published: Dec. 12, 2022

Different from common anti-tumor drugs, organoplatinum(II) metallacycles can integrate imaging and other therapeutic capabilities by incorporating corresponding functional donor ligands to enable potential applications in biomedicine. However, most of the emerging agents not only show poor solubility selectivity but also have serious side effects unsatisfactory efficacy encounter tendency develop drug resistance due their single treatment model. Herein, an metallacycle (PtM) was designed synthesized using coordination-driven self-assembly via combination a metallic chemotherapy precursor reactive oxygen species generating organic precursor. The hydrophobic PtM molecules were encapsulated cavity human heavy chain ferritin (HFn) during reassembly HFn prepare active targeting nanoagent HFn-PtM for use chemo-photodynamic therapy. nanoagents exhibited excellent stability buffer (pH 5 7.2), alleviating concern leakage circulation. A cellular uptake assay indicated that could efficiently enter specific cells overexpress transferrin receptor 1. In vitro vivo investigations revealed efficiency with negligible systemic toxicity. This work provides strategy easy construction multifunctional organoplatinum-based tumor-targeted drugs.

Language: Английский

Synergistic luminescent radicals and precursors as type-I photosensitizers for near-infrared fluorescence-guided tumor therapy DOI
Zhuo Li,

Zetao Dang,

Junshuai Ding

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 414, P. 135931 - 135931

Published: May 5, 2024

Language: Английский

Citations

1
Self-delivery nanodrug to manipulate tumor microenvironment for boosting photodynamic cancer immunotherapy DOI Creative Commons

Xianquan Feng,

Lingjun Zeng,

Lina Wu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117220 - 117220

Published: Aug. 1, 2024

Immunotherapy has captured attention for its high clinical efficacy. However, efficacy is limited by inadequate immune activation. Therefore, a platform to activate the system and amplify host's response against tumors urgently needed. Herein, self-delivery photodynamic nanodrug (VAC@HSA) reported as inducing immunogenic cell death (ICD), promoting recruitment of dendritic cells (DCs), normalizing tumor blood vessels. Firstly, verteporfin with laser assistance releases tumor-associated antigen induce ICD, while celecoxib downregulates prostaglandin E2 CCL5 DC recruitment. Moreover, vasculature normalized through axitinib, which contributes reducing hypoxia reversing immunosuppressive effects vascular endothelial growth factor. This joint action promotes infiltration effector into tumor. amplified excellent biocompatibility effectively inhibits lung metastasis produces cascade responses. Our study demonstrates practically innovative strategy activating cancer immunotherapy, can alter "cold" properties tumors.

Language: Английский

Citations

1
Small Molecules and Peptide Ligands Directed Nano-therapeutics for Precise Oncological Phototherapy: Emphasis Towards Enhancing Chemotherapeutic Active Tumor Targeting Efficacy DOI
Mona M. Agwa, Heba Elmotasem, Sarah A El-Lakany

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106313 - 106313

Published: Oct. 1, 2024

Language: Английский

Citations

1
Nanomaterial-enabled metabolic reprogramming strategies for boosting antitumor immunity DOI
Mengdi Ma, Yongliang Zhang, Kanyi Pu

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

We discuss the recent advances in nanomaterial design strategies for immunometabolic modulatory platforms and their applications targeting cancer-immunity cycle to enhance therapeutic outcomes.

Language: Английский

Citations

1
Pt(ii) metallacycles encapsulated by ferritin enable precise cancer combination chemo-photodynamic therapy DOI

Xuehong Min,

Ming Li, Wenjing Zhang

et al.

Journal of Materials Chemistry B, Journal Year: 2022, Volume and Issue: 11(5), P. 1090 - 1099

Published: Dec. 12, 2022

Different from common anti-tumor drugs, organoplatinum(II) metallacycles can integrate imaging and other therapeutic capabilities by incorporating corresponding functional donor ligands to enable potential applications in biomedicine. However, most of the emerging agents not only show poor solubility selectivity but also have serious side effects unsatisfactory efficacy encounter tendency develop drug resistance due their single treatment model. Herein, an metallacycle (PtM) was designed synthesized using coordination-driven self-assembly via combination a metallic chemotherapy precursor reactive oxygen species generating organic precursor. The hydrophobic PtM molecules were encapsulated cavity human heavy chain ferritin (HFn) during reassembly HFn prepare active targeting nanoagent HFn-PtM for use chemo-photodynamic therapy. nanoagents exhibited excellent stability buffer (pH 5 7.2), alleviating concern leakage circulation. A cellular uptake assay indicated that could efficiently enter specific cells overexpress transferrin receptor 1. In vitro vivo investigations revealed efficiency with negligible systemic toxicity. This work provides strategy easy construction multifunctional organoplatinum-based tumor-targeted drugs.

Language: Английский

Citations

5