The
management
of
diabetic
wounds
faces
significant
challenges
due
to
the
excessive
activation
reactive
oxygen
species
(ROS),
dysregulation
inflammatory
response,
and
impaired
angiogenesis.
A
substantial
body
evidence
suggests
that
aforementioned
diverse
factors
contributing
delayed
healing
may
be
associated
with
autophagy.
Impaired
autophagy
leads
endothelial
fibroblast
dysfunction
impedes
macrophage
phenotypic
transformation.
This
disruption
hinders
angiogenesis
extracellular
matrix
deposition,
ultimately
culminating
in
wound
healing.
Therefore,
biomaterials
possessing
regulatory
functions
hold
potential
for
clinical
applications
enhancing
wounds.
hybrid
multifunctional
hydrogel
(GelMa@SIS-Qu)
has
been
developed,
comprising
methacrylamide
gelatin
(GelMa),
a
small
intestine
submucosal
acellular
(SIS),
quercetin
nanoparticles,
which
demonstrates
capability
promote
promotion
not
only
reduces
ROS
levels
cells
enhances
their
antioxidant
activity
but
also
mitigates
ROS-induced
cell
apoptosis,
thereby
promoting
Furthermore,
facilitates
transformation
macrophages
from
M1
phenotype
M2
phenotype.
study
investigates
distinctive
mechanisms
GelMa@SIS-Qu
proposes
promising
therapeutic
strategy
treating
diabetes-related
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101473 - 101473
Published: Jan. 11, 2025
Magnesium
and
its
alloys
are
undoubtedly
ideal
candidates
for
manufacturing
new
bioabsorbable
vascular
stents
thanks
to
their
good
bio-absorbability
better
mechanical
characteristics.
However,
the
bottlenecks
that
restrict
clinical
application,
such
as
fast
corrosion
in
vivo,
poor
hemocompatibility,
inferior
surface
endothelial
regeneration
ability,
have
not
been
resolved
fundamentally.
In
this
study,
a
polydopamine
(PDA)
intermediate
layer
covalently
linked
with
acrylamide
was
first
constructed
on
alkali-heat-treated
magnesium
alloys,
followed
by
in-situ
polymerizing
methacryloyloxyethyl
sulfonyl
betaine
(SBMA)
(AAM)
fabricate
hydrogel
coating
ultraviolet
(UV)
polymerization.
Finally,
bivalirudin
selenocystamine
were
sequentially
grafted
onto
construct
multifunctional
bioactive
corrosion-resistant
excellent
antifouling,
anticoagulant
performance,
catalytic
liberation
of
NO
(nitric
oxide)
facilitate
cell
(EC)
growth.
The
outcomes
verified
could
only
significantly
resist
but
also
had
hydrophilicity
ability
selectively
promote
albumin
adsorption,
which
prevent
platelet
adhesion
activation
diminish
hemolysis
occurrence,
thereby
considerably
facilitating
properties.
At
same
time,
due
extracellular
matrix-like
characteristics
coating,
EC
growth
upregulate
secretion
factor
(VEGF)
cells
(ECs).
case
NO-liberation,
release
further
improve
blood
compatibility,
growth,
functional
expressions
ECs.
Therefore,
method
study
provides
an
effective
strategy
can
simultaneously
enhance
biocompatibility
magnesium-based
effectively
promoting
research
application
alloy
intravascular
stents.
APL Materials,
Journal Year:
2025,
Volume and Issue:
13(1)
Published: Jan. 1, 2025
Wound
healing
is
a
complex,
variable,
and
time-dynamic
repair
process.
Wounds
can
be
classified
as
acute
wounds
or
chronic
wounds,
effective
wound
management
still
major
challenge
in
clinical
nursing
settings.
The
microenvironment
collectively
regulated
by
internal
biomolecules,
external
drugs,
sanitation.
Traditional
dressings
(powders,
bandages,
sponges,
etc.)
often
have
poor
therapeutic
effects
during
processes
because
they
cannot
respond
to
the
dynamic
changes
over
long-term.
Stimulus-responsive
biomaterials,
which
are
activated
various
factors
intrinsic
influences,
hold
great
promise
for
precise
drug
delivery
controlled
release.
Various
stimulus-responsive
hydrogels
been
developed
recent
years,
exhibiting
range
of
“smart”
properties,
such
interacting
with
wound,
sensing
conditions
environmental
changes,
responding
accordingly,
thereby
effectively
promoting
healing.
This
review
discusses
latest
advancements
used
We
introduce
design
scheme
stimulus-response
detail
based
on
local
biological/biochemical
peculiarities
(pH,
reactive
oxygen
species
glucose,
enzymes,
physical
microenvironments
(temperature,
light,
ultrasound,
electric
fields,
etc.).
Furthermore,
we
explore
several
promising
tissue-engineered
constructs
(nanofibers,
scaffolds,
microneedles,
microspheres).
Finally,
summarize
basis
active
research
challenges,
current
progress,
development
trends
field.
The
management
of
diabetic
wounds
faces
significant
challenges
due
to
the
excessive
activation
reactive
oxygen
species
(ROS),
dysregulation
inflammatory
response,
and
impaired
angiogenesis.
A
substantial
body
evidence
suggests
that
aforementioned
diverse
factors
contributing
delayed
healing
may
be
associated
with
autophagy.
Impaired
autophagy
leads
endothelial
fibroblast
dysfunction
impedes
macrophage
phenotypic
transformation.
This
disruption
hinders
angiogenesis
extracellular
matrix
deposition,
ultimately
culminating
in
wound
healing.
Therefore,
biomaterials
possessing
regulatory
functions
hold
potential
for
clinical
applications
enhancing
wounds.
hybrid
multifunctional
hydrogel
(GelMa@SIS-Qu)
has
been
developed,
comprising
methacrylamide
gelatin
(GelMa),
a
small
intestine
submucosal
acellular
(SIS),
quercetin
nanoparticles,
which
demonstrates
capability
promote
promotion
not
only
reduces
ROS
levels
cells
enhances
their
antioxidant
activity
but
also
mitigates
ROS-induced
cell
apoptosis,
thereby
promoting
Furthermore,
facilitates
transformation
macrophages
from
M1
phenotype
M2
phenotype.
study
investigates
distinctive
mechanisms
GelMa@SIS-Qu
proposes
promising
therapeutic
strategy
treating
diabetes-related
