Transition Metal (Molybdenum)-Doped Drug-like Conformational Nanoarchitectonics with Altered Valence States (Mn2+/Mn4+ and Mo5+/Mo6+) for Augmented Cancer Theranostics DOI

Hong‐Ying Xia,

Ying Zhao,

Ruo-Yin Meng

et al.

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(11), P. 5864 - 5879

Published: Oct. 8, 2024

Despite the advancements in cancer therapy, delivering active pharmaceutical ingredients (APIs) using nanoparticles remains challenging due to failed conveyance of required drug payload, poor targeting ability, and biodistribution, hampering their clinical translation. Recently, appropriate design materials with intrinsic therapeutic functionalities has garnered enormous interest development various intelligent nanoplatforms. In this study, we demonstrate fabrication transition metal (molybdenum, Mo)-doped manganese dioxide (MnO2) nanoarchitectures, exhibiting diagnostic (magnetic resonance imaging, MRI) (chemodynamic CDT) functionalities. The facile hydrothermal approach-assisted Mo-doped MnO2 flower-like nanostructures offered tailorable morphologies altered dimensions, precise effects, exceptional biocompatibility, biodegradability tumor microenvironment. resultant defects doped Mo species exhibited peroxidase oxidase activities, improving glutathione (GSH) oxidation. two sets variable valence ion pairs (Mn2+/Mn4+ Mo5+/Mo6+) interplay could substantially improve Fenton-like reaction generate toxic hydroxyl radicals (•OH), thus achieving CDT-assisted antitumor effects. As inherent T1-MRI agents, these displayed excellent MRI efficacy vitro. Together, believe that conformational nanoarchitectures states potentiate drugless therapy pharmaceutics.

Language: Английский

Current advances in nanozyme-based nanodynamic therapies for cancer DOI
Xiangyang Zhou,

Shuaipeng Feng,

Qingqing Xu

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

5
Harnessing stimuli-responsive NO nanomaterials for advanced multi-disease therapy DOI
Junjie Zhang, Haiyang Guo, Longguang Tang

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216540 - 216540

Published: Feb. 27, 2025

Language: Английский

Citations

0
Near-Infrared Light-Controlled Nitric Oxide Delivery Combined with In Situ Activated Chemotherapy for Enhanced Multimodal Therapy DOI

Bing Ren,

Jing Liu, Yi Wang

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Development of nanoplatforms with in situ activation for chemotherapy represents a promising modality biomedical application. Herein, multifunctional nanoplatform, CMS@DTC@PDA@RuNO@FA (abbreviated as CDPNF NPs), was developed highly efficient antitumor therapy, which diethyldithiocarbamate (DTC)-loaded mesoporous Cu2MoS4 (CMS) nanoparticles were covered by polydopamine (PDA) layers and further covalently modified NO donor (RuNO) folic acid (FA)-directing moiety. Under the mild acidic tumor microenvironment (TME), NPs co-liberated DTC Cu2+ site, where formation cytotoxic Cu(DTC)2 complex effectively killed cells. Furthermore, under near-infrared (NIR) light irradiation, could deliver nitric oxide (NO) produce superoxide anions (O2•-), followed more toxic peroxynitrite (ONOO-), led to promoted cell apoptosis. 1064 nm NIR vivo experiments demonstrated an impressively high inhibition rate (∼97%) while good biocompatibility. This work activated approach precision medicine that might imply its potential clinical applications.

Language: Английский

Citations

0
Hydrogel-enabled ROS-GSH modulation for sustained copper-mediated chemodynamic therapy of oral squamous cell carcinoma DOI

Shihong Wu,

Xin Xia, Ronghui Zhou

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 383, P. 113772 - 113772

Published: April 23, 2025

Language: Английский

Citations

0
Transition Metal (Molybdenum)-Doped Drug-like Conformational Nanoarchitectonics with Altered Valence States (Mn2+/Mn4+ and Mo5+/Mo6+) for Augmented Cancer Theranostics DOI

Hong‐Ying Xia,

Ying Zhao,

Ruo-Yin Meng

et al.

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(11), P. 5864 - 5879

Published: Oct. 8, 2024

Despite the advancements in cancer therapy, delivering active pharmaceutical ingredients (APIs) using nanoparticles remains challenging due to failed conveyance of required drug payload, poor targeting ability, and biodistribution, hampering their clinical translation. Recently, appropriate design materials with intrinsic therapeutic functionalities has garnered enormous interest development various intelligent nanoplatforms. In this study, we demonstrate fabrication transition metal (molybdenum, Mo)-doped manganese dioxide (MnO2) nanoarchitectures, exhibiting diagnostic (magnetic resonance imaging, MRI) (chemodynamic CDT) functionalities. The facile hydrothermal approach-assisted Mo-doped MnO2 flower-like nanostructures offered tailorable morphologies altered dimensions, precise effects, exceptional biocompatibility, biodegradability tumor microenvironment. resultant defects doped Mo species exhibited peroxidase oxidase activities, improving glutathione (GSH) oxidation. two sets variable valence ion pairs (Mn2+/Mn4+ Mo5+/Mo6+) interplay could substantially improve Fenton-like reaction generate toxic hydroxyl radicals (•OH), thus achieving CDT-assisted antitumor effects. As inherent T1-MRI agents, these displayed excellent MRI efficacy vitro. Together, believe that conformational nanoarchitectures states potentiate drugless therapy pharmaceutics.

Language: Английский

Citations

3