Biomaterials that passively and actively target macrophages promote the regeneration of injured tissues DOI Creative Commons

Pengzhen Zhuang,

Yang Wu, Yu Chen

et al.

Biomedical Technology, Journal Year: 2024, Volume and Issue: 8, P. 17 - 49

Published: Oct. 1, 2024

Language: Английский

The Role of Neutrophils in Biomaterial-Based Tissue Repair—Shifting Paradigms DOI Creative Commons
Ana Beatriz Sousa, Judite N. Barbosa

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(6), P. 327 - 327

Published: June 19, 2023

Tissue engineering and regenerative medicine are pursuing clinical valid solutions to repair restore function of damaged tissues or organs. This can be achieved in different ways, either by promoting endogenous tissue using biomaterials medical devices replace tissues. The understanding the interactions immune system with how cells participate process wound healing critical for development successful solutions. Until recently, it was thought that neutrophils only initial steps an acute inflammatory response role eliminating pathogenic agents. However, appreciation upon activation longevity is highly increased fact plastic polarize into phenotypes led discovery new important actions neutrophils. In this review, we focus on roles resolution response, biomaterial-tissue integration subsequent repair/regeneration. We also discuss potential biomaterial-based immunomodulation.

Language: Английский

Citations

6
Development and In Vivo Assessment of an Injectable Cross‐Linked Cartilage Acellular Matrix‐PEG Hydrogel Scaffold Derived from Porcine Cartilage for Tissue Engineering DOI
Hyeon Jin Ju, Yun Bae Ji, Shina Kim

et al.

Macromolecular Bioscience, Journal Year: 2023, Volume and Issue: 23(6)

Published: March 28, 2023

Abstract The cartilage acellular matrix (CAM) derived from porcine cartilage, which does not induce significant inflammation and provides an environment conducive for cell growth differentiation, is a promising biomaterial candidate scaffold fabrication. However, the CAM has short period in vivo, vivo maintenance controlled. Therefore, this study aimed at developing injectable hydrogel using CAM. cross‐linked with biocompatible polyethylene glycol (PEG) cross‐linker to replace typically used glutaraldehyde (GA) cross‐linker. cross‐linking degree of by PEG (Cx‐CAM‐PEG) according ratios confirmed contact angle heat capacities measured differential scanning calorimetry. Cx‐CAM‐PEG suspension exhibits controllable rheological properties injectability. Additionally, suspensions no free aldehyde group are formed almost simultaneously injection. In realized ratio. certain host–cell infiltration negligible within near transplanted scaffold. These results suggest that suspensions, safe represent potential candidates (pre‐)clinical scaffolds.

Language: Английский

Citations

5
Versatile click alginate hydrogels with protease-sensitive domains as cell responsive/instructive 3D microenvironments DOI
Mariana I. Neves, Mariana V. Magalhães, Sílvia J. Bidarra

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 320, P. 121226 - 121226

Published: July 22, 2023

Language: Английский

Citations

5
Erythrocyte Membrane Coating Alleviate Immune Response And Promoted Adipogenesis In Adipose Matrix DOI
Kaiqi Chen, Jingyan Guan, Kaiyang Liu

et al.

Tissue Engineering Part A, Journal Year: 2024, Volume and Issue: unknown

Published: June 4, 2024

Xenotransplantation of acellular adipose matrix (AAM) has come to prominence as an intriguing option for soft tissue reconstruction. However, the presence immunogenic antigens within AAM can trigger unfavorable immune reactions, leading inadequate

Language: Английский

Citations

1
Biomaterials that passively and actively target macrophages promote the regeneration of injured tissues DOI Creative Commons

Pengzhen Zhuang,

Yang Wu, Yu Chen

et al.

Biomedical Technology, Journal Year: 2024, Volume and Issue: 8, P. 17 - 49

Published: Oct. 1, 2024

Language: Английский

Citations

1