Tissue Engineering Part B Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 6, 2025
Language: Английский
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(15), P. 18327 - 18343
Published: April 8, 2024
58S bioactive glass (BG) has effective biocompatibility and bioresorbable properties for bone tissue engineering; however, it limitations regarding antibacterial, antioxidant, mechanical properties. Therefore, we have developed BGAC biocomposites by reinforcing BG with silver ceria nanoparticles, which showed bactericidal forming inhibited zones of 2.13 mm (against Escherichia coli) 1.96 Staphylococcus aureus; evidenced disc diffusion assay) an increment in the antioxidant 39.9%. Moreover, elastic modulus, hardness, fracture toughness were observed to be increased ∼84.7% (∼51.9 GPa), ∼54.5% (∼3.4 ∼160% (∼1.3 MPam1/2), whereas specific wear rate was decreased ∼55.2% (∼1.9 × 10-11 m3/Nm). X-ray diffraction, high-resolution transmission electron microscopy, field emission scanning microscopy confirmed fabrication uniform distribution nanomaterials matrix. The addition nanoparticles matrix (in BGA) composite strengthening damaging cytoplasmic membrane bacterial cells. nanoceria (BGC) 44.5% (as 2,2-diphenyl-1-picrylhydrazyl assay). resazurin reduction assay MTT cytocompatibility against mouse embryonic fibroblast cells (NIH3T3) marrow stromal Overall, resulted comparable those cancellous bone, its antibacterial make a good candidate healing.
Language: Английский
Citations
5
Tissue Engineering Part B Reviews, Journal Year: 2024, Volume and Issue: 30(4), P. 477 - 489
Published: Jan. 6, 2024
The repair and regeneration of critical-sized bone defects remain an urgent challenge. Bone tissue engineering represents exciting solution for large defects. Recently, the importance innervation in tissue-engineered has been increasingly recognized. cross talk between nerve provides important clues regeneration. Furthermore, promotion angiogenesis by can accelerate new formation. However, mechanisms involved vascular nervous system have not yet established. In addition, simultaneous neurogenesis vascularization fully investigated. This article first review on effects enhancing osteogenesis dental engineering. Cutting-edge research through biomaterials repairs is reviewed. various nerve-related factors cells are discussed. Finally, novel clinical applications bone, dental, craniofacial also examined.
Language: Английский
Citations
4
Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11
Published: April 16, 2024
Neuro bone tissue engineering is a multidisciplinary field that combines both principles of neurobiology and to develop innovative strategies for repairing regenerating injured tissues. Despite the fact regeneration development are considered two distinct biological processes, yet can be reactivation in later life stages restore missing It noteworthy capabilities vary from one organism another (teleost fishes, hydra, humans), or even same dependent on itself (Human central nervous system vs. peripheral system). The skeletal highly innervated, plays role conveying signals connecting with organs, moreover it has been shown they play an important regeneration. Their conveyed by different cells' resident its endoneurium (fibroblasts, microphages, vasculature associated cells, Schwann cells) these cells secrete various growth factors (NGF, BDNF, GDNF, NT-3, bFGF) contribute regenerative phenotype. synchronize together regulating homeostasis through neurogenic neural circuits. Receptors peptides such as Serotonin, Leptin, Semaphorins, BDNF expressed playing homeostasis, metabolism This review will highlight crosstalk between nerves developmental well neuro-bone severe injuries.
Language: Английский
Citations
4
Advanced Science, Journal Year: 2024, Volume and Issue: 11(38)
Published: Aug. 9, 2024
Neurodegenerative diseases are global health challenges characterized by the progressive degeneration of nerve cells, leading to cognitive and motor impairments. The brain-gut-bone axis, a complex network that modulates multiple physiological systems, has gained increasing attention owing its profound effects on occurrence development neurodegenerative diseases. No comprehensive review been conducted clarify triangular relationship involving axis potential for innovative therapies disorders. In light this, new perspective is aimed propose interplay between brain, gut, bone highlighting their dynamic communication in diseases, as they modulate including nervous, immune, endocrine, metabolic systems. Therapeutic strategies maintaining balance brain regulation, intestinal microbiota improving skeletal health, also explored. intricate interactions within pose challenge effective treatments can comprehensively target this system. Furthermore, safety these requires further evaluation. This offers novel insights prevention treatment which have important implications clinical practice patient well-being.
Language: Английский
Citations
4
Tissue Engineering Part B Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 6, 2025
Language: Английский
Citations
0