Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 5, 2025
Abstract
Microgels
have
attracted
increasing
attention
as
drug
carriers
for
osteoarthritis
(OA)
treatment
due
to
their
injectability
and
modifiability.
However,
effectively
designing
high‐efficiency
drug‐loading
multifunctional
microgel
achieve
synergistic
therapy
of
OA
remains
a
challenge.
Here,
monodisperse,
small‐sized,
porous,
lubricated
microgels
composed
hyaluronic
acid
polysulfomethylacrylate
are
developed
using
multiple
Pickering
emulsion
process.
Then,
the
surface
is
modified
with
cartilage‐targeting
peptide
screened
through
phage
display
technology
create
targeted
microgels.
The
exhibit
porosity,
small
size
(≈20
µm)
swelling
ratio
up
4136.67%,
which
facilitate
efficient
loading,
delivery,
controlled
release
miR‐140,
maintaining
metabolic
balance
cartilage
matrix
inhibiting
development
OA.
Additionally,
demonstrate
remarkable
lubrication
performance
attributed
formation
hydration
layer
around
hydrophilic
groups
polymers.
in
vivo
data
sustained
miR‐140
by
microgels,
resulting
reduced
joint
wear,
decreased
osteophyte
formation,
effective
alleviation
progression.
This
work
not
only
offers
novel
method
preparation
but
also
lays
foundation
providing
new
strategies
clinical
translation
treatment.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 2, 2025
Metal-phenolic
networks
(MPNs),
which
comprise
supramolecular
amorphous
formed
by
interlinking
polyphenols
with
metal
ions,
garner
escalating
interest
within
the
realm
of
nanomedicine.
Presently,
a
comprehensive
synthesis
cumulative
research
advancements
and
utilizations
MPNs
in
nanomedicine
remains
absent.
Thus,
this
review
endeavors
to
firstly
delineate
characteristic
polyphenols,
their
intricate
interaction
modalities
MPNs.
Subsequently,
it
elucidates
merits
demerits
diverse
methodologies
employed
for
MPNs,
alongside
exploring
potential
functional
attributes.
Furthermore,
consolidates
applications
across
various
nanomedical
domains
encompassing
tumor
therapy,
antimicrobial
interventions,
medical
imaging,
among
others.
Moreover,
meticulous
exposition
journey
from
ingress
into
human
body
eventual
excretion
is
provided.
Lastly,
persistent
challenges
promising
avenues
pertaining
are
delineated.
Hence,
offering
on
current
nanomedicine,
consequently
indirect
insights
clinical
implementation.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(11), P. 13573 - 13584
Published: March 5, 2024
Periodontitis,
a
complex
inflammatory
disease
initiated
by
bacterial
infections,
presents
significant
challenge
in
public
health.
The
increased
levels
of
reactive
oxygen
species
and
the
subsequent
exaggerated
immune
response
associated
with
periodontitis
often
lead
to
alveolar
bone
resorption
tooth
loss.
Herein,
we
develop
multifunctional
metal–phenolic
composites
(i.e.,
Au@MPN-BMP2)
address
nature
periodontitis,
where
gold
nanoparticles
(AuNPs)
are
coated
networks
(MPNs)
morphogenetic
protein
2
(BMP2).
In
this
design,
MPNs
exhibit
remarkable
antibacterial
antioxidant
properties,
AuNPs
BMP2
promote
osteogenic
differentiation
marrow
mesenchymal
stem
cells
under
conditions.
rat
model
treatment
Au@MPN-BMP2
leads
notable
therapeutic
outcomes,
including
mitigated
oxidative
stress,
reduced
progression
inflammation,
prevention
These
results
highlight
multifunctionality
as
promising
approach
for
addressing
both
microbial
causative
factors
an
overactivated
response.
We
envision
that
rational
design
will
provide
versatile
nanoplatforms
tissue
regeneration
potential
clinical
applications.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(26), P. 33205 - 33222
Published: June 25, 2024
In
diabetic
patients
with
skin
injuries,
bacterial
proliferation,
accumulation
of
reactive
oxygen
species
(ROS)
in
the
tissues,
and
impaired
angiogenesis
make
wound
healing
difficult.
Therefore,
eliminating
bacteria,
removing
ROS,
promoting
are
necessary
for
treating
acute
wounds.
this
study,
benefiting
from
ability
polyphenols
to
form
a
metal-phenolic
network
(MPN)
metal
ions,
TA-Eu
MPN
nanoparticles
(TM
NPs)
were
synthesized.
The
prepared
photothermal
agent
CuS
NPs
TM
then
loaded
onto
supporting
base
needle
tips
PVA/HA
(PH)
microneedles,
respectively,
obtain
PH/CuS/TM
microneedles.
Antibacterial
experiments
showed
that
microneedles
could
remove
bacteria
by
effect.
vitro
effectively
scavenge
inhibit
macrophage
polarization
M1
type,
induce
M2
type
as
well
have
promote
vascular
endothelial
cell
migration
angiogenesis.
Furthermore,
vivo
accelerated
inhibiting
pro-inflammatory
cytokines
rat
model.
efficient
antibacterial,
ROS
scavenging,
anti-inflammatory,
immunomodulatory,
angiogenic
abilities
hold
promise
dressings
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(16), P. 10667 - 10687
Published: April 9, 2024
Cartilage
injuries
are
escalating
worldwide,
particularly
in
aging
society.
Given
its
limited
self-healing
ability,
the
repair
and
regeneration
of
damaged
articular
cartilage
remain
formidable
challenges.
To
address
this
issue,
nanomaterials
leveraged
to
achieve
desirable
outcomes
by
enhancing
mechanical
properties,
optimizing
drug
loading
bioavailability,
enabling
site-specific
targeted
delivery,
orchestrating
cell
activities
at
nanoscale.
This
review
presents
a
comprehensive
survey
recent
research
nanomedicine
for
repair,
with
primary
focus
on
biomaterial
design
considerations
advances.
The
commences
an
introductory
overview
intricate
microenvironment
further
delves
into
key
parameters
crucial
treating
damage,
including
microstructure,
surface
charge,
active
targeting.
focal
point
lies
advances
nano
delivery
systems
nanotechnology-enabled
3D
matrices
repair.
We
discuss
compositions
properties
these
elucidate
how
materials
impact
cartilage.
underscores
pivotal
role
nanotechnology
improving
efficacy
biomaterials
utilized
treatment
damage.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(33)
Published: March 4, 2024
Abstract
Osteoarthritis
(OA)
is
a
degenerative
disease
caused
by
variety
of
factors
with
joint
pain
as
the
main
symptom,
including
fibrosis,
chapping,
ulcers,
and
loss
cartilage.
Traditional
treatment
can
only
delay
progression
OA,
classical
delivery
system
have
many
side
effects.
In
recent
years,
microspheres
shown
great
application
prospects
in
field
OA
treatment.
Microspheres
support
cells,
reproduce
natural
tissue
microenvironment
vitro
vivo,
are
an
efficient
for
release
drugs
or
biological
agents,
which
promote
cell
proliferation,
migration,
differentiation.
Thus,
they
been
widely
used
cartilage
repair
regeneration.
this
review,
preparation
processes,
basic
materials,
functional
characteristics
various
commonly
systematically
reviewed.
Then
it
introduced
surface
modification
strategies
that
improve
properties
discussed
series
applications
microsphere
functionalized
scaffolds
Finally,
based
on
bibliometrics
research,
research
development,
future
potential,
possible
hotspots
therapy
dynamically
evaluated.
The
comprehensive
systematic
review
will
bring
new
understanding
to
OA.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(41), P. 28335 - 28348
Published: Oct. 2, 2024
Diabetic
foot
ulcers
(DFUs)
are
a
significant
challenge
in
the
clinical
care
of
diabetic
patients,
often
necessitating
limb
amputation
and
compromising
quality
life
expectancy
this
cohort.
Minimally
invasive
therapies,
such
as
modular
scaffolds,
at
forefront
current
DFU
treatment,
offering
an
efficient
approach
for
administering
therapeutics
that
accelerate
tissue
repair
regeneration.
In
study,
we
report
facile
method
fabricating
granular
nanofibrous
microspheres
(NMs)
with
predesigned
structures
porosities.
The
proposed
technology
combines
electrospinning
electrospraying
to
develop
therapeutic
option
DFUs.
Specifically,
porous
NMs
were
constructed
using
electrospun
poly(lactic-
