ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(47), P. 54207 - 54220
Published: Nov. 17, 2023
Tumor
drug
resistance
caused
by
the
tumor
microenvironment
is
an
extremely
difficult
problem
for
researchers
to
solve.
Nanoplatforms
that
integrate
diagnosis
and
treatment
have
great
advantages
in
treatment,
but
design
synthesis
of
simple
efficient
nanoplatforms
still
face
tremendous
challenges.
In
this
study,
a
novel
Mn/Au@ir820/GA-CD133
nanoprobe
was
developed.
The
manganese
dioxide/gold
particles
were
prepared
coprecipitation/assembly,
chemically
coupled
with
CD133
antibody,
finally
loaded
photosensitive
IR820
heat
shock
protein
inhibitor
Ganetespib.
demonstrated
good
tumor-targeting
ability,
increased
level
singlet
oxygen
produced
from
laser
irradiation
effectively
alleviating
hypoxia,
decreased
threshold
tolerance
downregulating
expression
HSP90
tissues.
This
successfully
inhibited
growth
progression
tissues
tumor-bearing
mouse
model
improving
effectiveness
photodynamic
low-temperature
photothermal
combination
therapy.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
36, P. 595 - 612
Published: June 1, 2024
Bacterial
infection
of
cutaneous
wounds
can
easily
lead
to
occurrence
chronic
and
even
more
serious
diseases.
Therefore,
multifunctional,
biodegradable,
reusable
wound
dressings
that
quickly
manage
promote
healing
are
urgently
desired.
Herein,
inspired
by
the
"capturing
killing"
action
Small,
Journal Year:
2023,
Volume and Issue:
20(18)
Published: Dec. 1, 2023
Abstract
Wounds
and
the
subsequent
formation
of
scars
constitute
a
unified
complex
phased
process.
Effective
treatment
is
crucial;
however,
diverse
therapeutic
approaches
for
different
wounds
scars,
as
well
varying
needs
at
stages,
present
significant
challenges
in
selecting
appropriate
interventions.
Microneedle
patch
(MNP),
novel
minimally
invasive
transdermal
drug
delivery
system,
has
potential
integrated
programmed
various
diseases
shown
promising
applications
types
scars.
In
this
comprehensive
review,
latest
biotechnological
innovations
MNPs
these
fields
are
thoroughly
explored,
summarizing
their
powerful
abilities
to
accelerate
healing,
inhibit
scar
formation,
manage
related
symptoms.
Moreover,
scenarios
discussed.
Additionally,
side
effects,
manufacturing
processes,
material
selection
explore
clinical
translational
investigated.
This
groundwork
can
provide
theoretical
basis
serve
catalyst
future
pursuit
favorable
options
skin
tissue
regeneration.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(47), P. 54207 - 54220
Published: Nov. 17, 2023
Tumor
drug
resistance
caused
by
the
tumor
microenvironment
is
an
extremely
difficult
problem
for
researchers
to
solve.
Nanoplatforms
that
integrate
diagnosis
and
treatment
have
great
advantages
in
treatment,
but
design
synthesis
of
simple
efficient
nanoplatforms
still
face
tremendous
challenges.
In
this
study,
a
novel
Mn/Au@ir820/GA-CD133
nanoprobe
was
developed.
The
manganese
dioxide/gold
particles
were
prepared
coprecipitation/assembly,
chemically
coupled
with
CD133
antibody,
finally
loaded
photosensitive
IR820
heat
shock
protein
inhibitor
Ganetespib.
demonstrated
good
tumor-targeting
ability,
increased
level
singlet
oxygen
produced
from
laser
irradiation
effectively
alleviating
hypoxia,
decreased
threshold
tolerance
downregulating
expression
HSP90
tissues.
This
successfully
inhibited
growth
progression
tissues
tumor-bearing
mouse
model
improving
effectiveness
photodynamic
low-temperature
photothermal
combination
therapy.
