Topochemical-like bandgap regulation engineering: A bismuth thiooxide nanocatalyst for breast cancer phototherapy

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 662, P. 171 - 182

Published: Feb. 8, 2024

Language: Английский

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Bi‐Pt Heterojunction Cascade Reaction Platform for Sono‐Immunotherapy of Tumors via PANoptosis and Ferroptosis

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Abstract Sonodynamic therapy (SDT) represents a promising, noninvasive, and precise treatment modality for tumors, demonstrating significant potential in clinical applications. However, the efficiency of sonosensitizers generating reactive oxygen species (ROS) is often limited by rapid electron‐hole recombination. In this study, BiF 3 @BiOI synthesized via co‐precipitation method, followed in‐situ reduction to decorate it with Pt nanoparticles, resulting @BiOI@Pt‐PVP (BBP) nanocomposite enhancing SDT efficacy. The formation heterojunction enhances charge separation ability. decoration nanoparticles narrows bandgap alters band positions Fermi level BBP, which can effectively mitigate recombination pairs facilitate cascade reaction ROS, thereby improving ROS generation ultrasound excitation. Additionally, bismuth ions BBP generated holes consume glutathione, exacerbating cellular oxidative damage, triggering PANoptosis ferroptosis. Furthermore, demonstrate peroxidase‐like activity, catalyzing endogenous hydrogen peroxide oxygen. These functions are helpful against tumors alleviating hypoxic conditions, reshaping microenvironment, modulating immune cell infiltration capacity, efficacy immunotherapy. dual strategy forming heterojunctions sensitization noble metals sono‐catalytic therapy‐induced activation tumor treatment.

Language: Английский

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Ternary Schottky Junction for Sonocatalytic Water Splitting in Gas‐Immunotherapy‐Mediated Cancer Treatment

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Hydrogen therapy has shown new potential in cancer treatment, particularly high-pressure and hypoxic areas, where it demonstrates the ability to alter tumor microenvironment regulate metabolism. disrupts mitochondrial function of cells, interferes with their energy metabolism, ultimately leads depletion apoptosis. In this study, a sonocatalyst (BPM), is designed generate hydrogen oxygen situ within tumors, further enhancing therapeutic efficacy. The mesocrystalline structure BPM, composed bismuth fluoride, polyoxometalates, molybdenum carbide, significantly improves charge separation electron transfer efficiency under ultrasound irradiation, resulting an efficient water-splitting reaction. By simultaneously generating depleting glutathione, BPM effectively triggers oxidative stress alleviates hypoxia, thereby disrupting inhibiting metabolism cells. Additionally, enhances antitumor immune responses by promoting dendritic cell maturation, activating T lymphocytes, polarizing macrophages toward M1 phenotype, reversing immunosuppressive state microenvironment. results indicate that holds for gas-immunotherapy combination treatments, offering multifunctional strategy improve outcomes.

Language: Английский

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Apoptosis‐Sensitizing Tumor Nanomedicine by Regulating Pyroptosis‐Associated Inflammatory Cell Death

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: May 25, 2024

Abstract The vigorous development of cancer nanomedicine has revolutionized traditional oncology medicine, but it is also limited by the continuous mutation cunning cells, leading to apoptosis insensitivity and therapeutic disappointment. Inflammatory‐regulated cell death (RCD), especially pyroptosis‐related death, demonstrates huge potential for sensitization due its unique biochemical characteristics. aim this research present a thorough synopsis current knowledge on pyroptosis‐associated inflammatory including pyroptosis, cuproptosis, PANoptosis, synergistic function in nano therapy. Paradigm studies death‐mediated apoptosis‐sensitizing tumor nanotherapeutics are introduced detail, coordination mechanisms based nanomaterials discussed. In addition, multi‐angle analysis future prospects pyroptosis‐sensitized various emphasized further expand application scope RCD. It believed that emerging auxiliary treatments RCD will greatly promote progress nanomedicine.

Language: Английский

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Charge Separation‐Engineered Piezoelectric Ultrathin Nanorods Modulate Tumor Stromal Microenvironment and Enhance Cell Immunogenicity for Synergistically Piezo‐Thermal‐Immune Therapy

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 16, 2024

Abstract The tumor microenvironment (TME) is characterized by hypoxia and low immunogenicity, with a dense rigid extracellular matrix (ECM) that impedes the diffusion of therapeutic agents immune cells, thereby limiting efficacy immunotherapy. To overcome these challenges, an oxygen defect piezoelectric‐photothermal sensitizer, bismuth vanadate nanorod‐supported platinum nanodots (BVP) developed. integration enhances photothermal effect improves charge separation efficiency under ultrasound, leading to increased heat generation production reactive species (ROS) oxygen. Platinum also catalyzes conversion hydrogen peroxide in TME oxygen, which serves as both ROS source means alleviate hypoxia, reversing immunosuppressive TME. Moreover, coordination ions glutathione further amplifies cellular oxidative stress. generated not only denature collagen ECM, facilitating deeper penetration BVP into but induce immunogenic cell death cells. Through “degeneration penetration” strategy, photoacoustic therapy effectively activates inhibiting growth metastasis. This study introduces pioneering approach design antitumor nanomedicines aimed at characteristics

Language: Английский

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Light-Triggered Bismuth-Based Nanosphere as a Dual-Inductive Nanomedicine for Antitumor Immunotherapy

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

The immunosuppressive microenvironment of the tumor is an important factor that seriously affects effect immunotherapy. Programmed cell death, including apoptosis and necroptosis, has shed light on antitumor therapy could synergistically activate immunity. Herein, S-doped bismuth oxide lychee-like nanospheres (BiOSSs) are presented to realize apoptosis- necroptosis-mediated treatment strategies. Under laser irradiation, BiOSS demonstrated exceptional capabilities in reactive oxygen species generation heat production. After BiOSS-triggered phototherapy, characteristic markers necroptosis were significantly changed membrane was damaged. Moreover, BiOSS-induced apoptosis/necroptosis result immune response obtain exciting effects. flow cytometry results revealed costimulatory molecules CD86 CD80 expressions dendritic cells (DCs) increased after apoptosis/necroptosis, indicating DC maturation, further promoting activation CD8+ cytotoxic T lymphocytes, finally inhibiting lung metastasis. Overall, phototherapy shows a strategy for immunotherapy with potential clinical application.

Language: Английский

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Ultrasound-enhanced dual-responsive bismuth nanocatalysts for alleviating tumor hypoxia and promoting breast cancer sonodynamic-immunotherapy

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160292 - 160292

Published: Feb. 1, 2025

Language: Английский

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Radioactive Diselenide Bonded Covalent Organic Framework

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Covalent organic frameworks (COFs) are porous crystals of high potential in biomedical applications. The chemical bonds within COF structures critical for the overall therapeutic performance. Here, design and synthesis radioactive reported by introducing labile diselenide into structure backbone. This bonded COF, PorSe-CuPt, constructed from Cu Pt ion porphyrin units, is capable bond cleavage upon irradiation, thus releasing drug molecule, CBL0137, carried pores. Concerted with promotion X-ray absorption Pt2⁺ enrichment oxygen Cu2⁺, robust PANoptosis achieved as well improved immunosuppressive tumor microenvironment, thereby drastically enhancing effectiveness radiotherapy. integration backbone demonstrates possible application clip-off chemistry search highly responsible compatible biomaterials.

Language: Английский

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Engineering oxygen vacancies in scaffold for enhanced photodynamic antibacterial efficacy

Vacuum, Journal Year: 2025, Volume and Issue: unknown, P. 114151 - 114151

Published: March 1, 2025

Language: Английский

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Biodegradable Bismuth Nanostructures as a Ferroptosis Inducer for Phototherapy of Breast Cancer

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(12), P. 14406 - 14418

Published: June 7, 2024

The therapeutic efficacy of monotherapy on tumors is often limited due to the constraints tumor response conditions, significantly impacting clinical treatment outcomes. In this study, we design a collaborative nanosystem (BBSP) that combines photodynamic therapy (PDT) and photothermal (PTT). system formulated by doping sulfur ions modulate wide band gap BiF3 semiconductor nanospheres. introduction its combination with bismuth not only enhance light absorption but also introduce oxygen vacancies local surface plasmon resonance effect bismuth. Compared BiF3, reduced carrier separation efficiency improved. Under irradiation 520 nm laser, electrons reduce in process transition meanwhile give energy O2, producing large number reactive species (ROS). Simultaneously, holes valence oxidize glutathione (GSH), coordination ion GSH further depletes GSH. RNA sequencing results reveal downregulation GPX4 cells, inducing ferroptosis. Additionally, sulfide augmented absorption, synergizing heat, thereby increasing oxidative damage inhibiting growth. BBSP emerges as promising strategy for treatment, orchestrating ferroptosis apoptosis through combined application PDT PTT.

Language: Английский

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