Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications

Advanced Science, Journal Year: 2023, Volume and Issue: 10(30)

Published: Aug. 26, 2023

Nitric oxide (NO) is a gaseous molecule that has central role in signaling pathways involved numerous physiological processes (e.g., vasodilation, neurotransmission, inflammation, apoptosis, and tumor growth). Due to its form, NO short half-life, physiology concentration dependent, often restricting function target site. Providing from an external source beneficial promoting cellular functions treatment of different pathological conditions. Hence, the multifaceted pathology garnered massive interest developing strategies deliver exogenous for various regenerative biomedical complexities. NO-releasing platforms or donors capable delivering controlled sustained manner tissues organs have advanced past few decades. This review article discusses detail generation via enzymatic synthase as well multiple biological modulates. The methods incorporating into diverse biomaterials including physical, chemical, supramolecular techniques are summarized. Then, these highlighted terms advancing medical problems.

Language: Английский

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Nanomaterials-based photothermal therapies for antibacterial applications

Materials & Design, Journal Year: 2023, Volume and Issue: 233, P. 112231 - 112231

Published: Aug. 9, 2023

Bacterial infection continues to be one of the biggest threats human health. The therapeutic effect is significantly reduced as a result development super-bacteria-resistant bacteria due overuse antibiotics for conventional antimicrobial treatment. emergence drug-resistant makes it necessary develop new treatments. Following successful application photothermal therapy in field oncology treatment, more and researchers are applying treatments achieving important results, especially treatment bacterial infections. As non-invasive anti-infection method, has advantages broad-spectrum properties, short period, low systemic impact. In PTT, efficacy strongly depends on different laser properties choice agents (PTAs). purpose this review discuss most recent developments nanomaterials that antibacterial. We will delve into principles spectrum PTAs provide summary current synthesis, classification, structural features, physicochemical antibacterial performance research. challenges future prospects enhanced cytotoxicity investigated.

Language: Английский

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Two-Dimensional Materials for Highly Efficient and Stable Perovskite Solar Cells

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: May 23, 2024

Perovskite solar cells (PSCs) offer low costs and high power conversion efficiency. However, the lack of long-term stability, primarily stemming from interfacial defects susceptible metal electrodes, hinders their practical application. In past few years, two-dimensional (2D) materials (e.g., graphene its derivatives, transitional dichalcogenides, MXenes, black phosphorus) have been identified as a promising solution to solving these problems because dangling bond-free surfaces, layer-dependent electronic band structures, tunable functional groups, inherent compactness. Here, recent progress 2D material toward efficient stable PSCs is summarized, including role both interface electrodes. We discuss beneficial effects on perovskite growth, energy level alignment, defect passivation, well blocking external stimulus. particular, unique properties form van der Waals heterojunction at bottom are emphasized. Finally, perspectives further development using provided, such designing high-quality heterojunction, enhancing uniformity coverage nanosheets, developing new materials-based

Language: Английский

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A cascaded enzyme system based on the catalase-like activity of Ti3C2Tx MXene nanosheets for the efficient combination cancer therapy

Nano Today, Journal Year: 2023, Volume and Issue: 54, P. 102059 - 102059

Published: Nov. 9, 2023

Language: Английский

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Protective mechanism of fruit vinegar polyphenols against AGEs-induced Caco-2 cell damage

Food Chemistry X, Journal Year: 2023, Volume and Issue: 19, P. 100736 - 100736

Published: June 6, 2023

Accumulation of advanced glycation end products (AGEs) is linked with development or aggravation many degenerative processes disorders. Fruit vinegars are rich in polyphenols that can be a good dietary source AGEs inhibitors. In this study, eight kinds were prepared. Among them, the highest polyphenol and flavonoid content orange vinegar kiwi fruit vinegar, respectively. Ferulic acid, vanillic chlorogenic p-coumaric caffeic catechin, epicatechin main vinegars. Then, we measured inhibitory effect on fluorescent AGEs, found had rate. Data here suggested its components epicatechin, acid could effectively reduce level ROS, RAGE, NADPH inflammatory factors Caco-2 cells. Our research provided theoretical basis for application as inhibitor.

Language: Английский

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Multifunctional iron-apigenin nanocomplex conducting photothermal therapy and triggering augmented immune response for triple negative breast cancer

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 655, P. 124016 - 124016

Published: March 19, 2024

Language: Английский

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Ti3C2Tx MXene quantum dots coated hollow manganese dioxide nanoparticles for tumor combination therapy and magnetic resonance imaging

Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 39, P. 102171 - 102171

Published: June 24, 2024

Language: Английский

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A multifunctional cascade enzyme system for enhanced starvation/chemodynamic combination therapy against hypoxic tumors

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 666, P. 244 - 258

Published: April 6, 2024

Language: Английский

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Ti3C2Tx MXene nanosheet-based drug delivery/cascaded enzyme system for combination cancer therapy and anti-inflammation

Applied Materials Today, Journal Year: 2024, Volume and Issue: 38, P. 102215 - 102215

Published: May 3, 2024

Language: Английский

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Oxygen and Heat Dual‐Driven Stomatocyte Nanomotors for Highly Efficient Inflammation‐Relieved Breast Tumor Photothermal Therapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Abstract The development of nanomedicines for autonomous motion‐promoted deep tumor treatment without the generation inflammatory damage to normal tissues remains an extreme challenge. Herein, design oxygen/heat dual‐driven stomatocyte nanomotor is showcased by integrating gold (Au) nanoparticles (NPs) and cerium oxide (CeO 2‐x ) NPs into artificial stomatocytes (Ce/Au‐Stomatocytes) that are further coated with cancer cell membranes (CM). prepared Ce/Au‐Stomatocytes anisotropic morphology possess multiple enzyme‐mimetic activities desired motion performances upon laser irradiation, can actively accumulate at site through CM‐mediated homotypic targeting. Importantly, CeO inside enable oxygen production in microenvironment, thus relieving hypoxia helping deeply enter region via oxygen‐induced motion. Upon irradiation region, surface‐coated Au be activated generate heat induce thermophoretic highly efficient photothermal therapy (PTT) motion‐enhanced penetration. More importantly, alleviate abnormal responses triggered PTT, thereby reducing skin after irradiation. Overall, this study provides a new approach developing bionic, functional, nanomotors promising performance enhanced antitumor PTT non‐desired inflammation effect.

Language: Английский

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