Interactive Journal of Medical Research,
Journal Year:
2025,
Volume and Issue:
14, P. e66286 - e66286
Published: Feb. 26, 2025
Background
Ferroptosis,
as
a
novel
modality
of
cell
death,
holds
significant
potential
in
elucidating
the
pathogenesis
and
advancing
therapeutic
strategies
for
breast
cancer.
Objective
This
study
aims
to
comprehensively
analyze
current
ferroptosis
research
future
trends,
guiding
cancer
advancements
innovative
treatment
strategies.
Methods
used
R
package
Bibliometrix
(Department
Economic
Statistical
Sciences
at
University
Naples
Federico
II),
VOSviewer
(Centre
Science
Technology
Studies
Leiden
University),
CiteSpace
(Drexel
University’s
College
Information
Technology),
conduct
bibliometric
analysis
387
papers
on
from
Web
Core
Collection.
The
covers
authors,
institutions,
journals,
countries
or
regions,
publication
volumes,
citations,
keywords.
Results
number
publications
related
this
field
has
surged
annually,
with
China
United
States
collaborating
closely
leading
output.
Sun
Yat-sen
stands
out
among
while
journal
Frontiers
Oncology
author
Efferth
T
contribute
significantly
field.
Highly
cited
within
domain
primarily
focus
induction
ferroptosis,
protein
regulation,
comparisons
other
modes
providing
foundation
treatment.
Keyword
highlights
maturity
glutathione
peroxidase
4-related
research,
subtypes
emerging
motor
themes
tumor
microenvironment,
immunotherapy,
prognostic
models
identified
basic
themes.
Furthermore,
application
nanoparticles
serves
an
additional
complement
Conclusions
status
focuses
exploration
relevant
theoretical
mechanisms,
whereas
trends
mechanisms
emphasize
investigation
strategies,
particularly
clinical
immunotherapy
microenvironment.
Nanotherapy
demonstrated
domain.
Future
directions
should
deepen
accelerate
translation
findings
provide
new
insights
innovation
development
Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
21(3), P. 1038 - 1055
Published: Feb. 12, 2024
Antibody
drug
conjugates
(ADCs)
have
emerged
as
a
new
promising
class
of
anti-
cancer
agents.
However,
limitations
such
higher
costs
and
unavoidable
immunogenicity
due
to
their
relatively
large
structures
cannot
be
ignored.
Therefore,
the
development
lightweight
drugs
small
molecule–drug
(SMDCs)
based
on
ADC
design
idea
has
become
option
for
targeted
therapy.
SMDCs
are
derived
from
coupling
small-molecule
targeting
ligands
with
cytotoxic
drugs.
They
composed
three
parts:
ligands,
molecules,
linkers.
Compared
ADCs,
can
more
rapidly
evenly
dispersed
into
tumor
tissues,
low
cost
no
immunogenicity.
In
this
article,
we
will
give
comprehensive
review
different
types
currently
under
clinical
trials
provide
ideas
inspirations
clinically
applicable
SMDCs.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
169, P. 115866 - 115866
Published: Nov. 10, 2023
Triple-negative
breast
cancer
(TNBC),
the
most
aggressive
form
of
cancer,
presents
severe
threats
to
women's
health.
Therefore,
it
is
critical
find
novel
treatment
approaches.
Ferroptosis,
a
newly
identified
programmed
cell
death,
marked
by
buildup
lipid
reactive
oxygen
species
(ROS)
and
high
iron
concentrations.
According
previous
studies,
ferroptosis
sensitivity
can
be
controlled
number
metabolic
events
in
cells,
such
as
amino
acid
metabolism,
metabolism.
Given
that
TNBC
tumors
are
rich
lipids,
inducing
these
potential
approach
for
treatment.
Notably,
adaptability
cells
allows
them
coordinate
an
attack
on
one
or
more
pathways
initiate
ferroptosis,
offering
perspective
improve
drug
resistance
clinical
therapy
TNBC.
However,
clear
picture
still
needs
completely
revealed.
In
this
review,
we
provide
overview
recent
advancements
regarding
connection
between
acid,
iron,
metabolism
We
also
discuss
probable
significance
innovative
target
chemotherapy,
radiotherapy,
immunotherapy,
nanotherapy
natural
product
TNBC,
highlighting
its
therapeutic
application
prospects.
Nano Letters,
Journal Year:
2023,
Volume and Issue:
23(16), P. 7665 - 7674
Published: Aug. 3, 2023
Precise
manipulation
of
cancer
cell
death
by
harnessing
reactive
oxygen
species
(ROS)
is
a
promising
strategy
to
defeat
malignant
tumors.
However,
it
quite
difficult
produce
active
ROS
with
spatial
precision
and
regulate
their
biological
outcomes.
We
succeed
here
in
selectively
generating
short-lived
lipid-reactive
hydroxyl
radicals
(•OH)
adjacent
membranes,
successively
eliciting
lipid
peroxidation
ferroptosis.
DiFc-K-pY,
phosphorylated
self-assembling
precursor
that
consists
two
branched
Fc
moieties
interacts
specifically
epidermal
growth
factor
receptor,
can
situ
membrane-bound
nanofibers
enrich
ferrocene
on
membranes
response
alkaline
phosphatase.
Within
the
acidic
tumor
microenvironment,
DiFc-K-pY
efficiently
convert
tumoral
H2O2
•OH
around
target
via
Fenton-like
reactions,
leading
ferroptosis
good
cellular
selectivity.
Our
successfully
prevents
progression
acceptable
biocompatibility
through
intratumoral
administration.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(42), P. 10786 - 10817
Published: Jan. 1, 2024
The
review
highlights
the
potential
of
RGD-conjugated
AuNPs
in
cancer
diagnosis
and
treatment,
including
breast
cancer.
It
emphasizes
need
for
further
research
to
fully
realize
this
technology’s
inspire
future
investigations.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 23, 2024
Photodynamic
therapy
and
ferroptosis
induction
have
risen
as
vanguard
oncological
interventions,
distinguished
by
their
precision
ability
to
target
vulnerabilities
in
cancer
cells.
therapy's
non-invasive
profile
selective
cytotoxicity
complement
ferroptosis'
unique
mode
of
action,
which
exploits
iron-dependent
lipid
peroxidation,
offering
a
pathway
overcome
chemoresistance
with
lower
systemic
impact.
The
synergism
between
photodynamic
is
underscored
the
depletion
glutathione
peroxidase
four
inhibitions
therapy-induced
reactive
oxygen
species,
amplifying
peroxidation
enhancing
ferroptotic
cell
death.
This
synergy
presents
an
opportunity
refine
treatment
modulating
redox
homeostasis.
Porphyrin-based
nanoscale
metal-organic
frameworks
hybrid
structures
exceptional
properties.
These
can
serve
platform
for
integrating
through
carefully
designed
functions.
nanostructures
be
engineered
deliver
multiple
therapeutic
modalities
simultaneously,
marking
pivotal
advance
multimodal
therapy.
review
synthesizes
recent
progress
porphyrin-modified
combined
ferroptosis,
delineating
mechanisms
that
underlie
synergistic
effects
context.
It
underscores
potential
porphyrin-based
advanced
nanocarriers
oncology,
propelling
field
toward
more
efficacious
tailored
treatments.
