Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 372, P. 386 - 402
Published: June 25, 2024
Language: Английский
Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107379 - 107379
Published: Aug. 30, 2024
Tuberculosis (TB), a deadly disease caused by Mycobacterium tuberculosis (Mtb) infection, remains one of the top killers among infectious diseases worldwide. How to increase targeting effects current anti-TB chemotherapeutics and enhance immunological responses big challenge in TB drug-resistant treatment. Here, mannose functionalized polyetherimide protected graphene oxide system (GO-PEI-MAN) was designed for macrophage-targeted antibiotic (rifampicin) autophagy inducer (carbamazepine) delivery achieve more effective Mtb killings combining targeted drug killing host clearance. GO-PEI-MAN demonstrated selective uptake vitro macrophages ex vivo from macaques. The endocytosed would be transported into lysosomes, where loaded Rif@Car@GO-PEI-MAN undergo accelerated release acidic lysosomal conditions. could significantly promote apoptosis infected macrophages, as well induce anti-bacterial M1 polarization IFN-γ nitric production. Collectively, effectively enhanced intracellular than rifampicin, carbamazepine or alone reduce mycobacterial burdens lung mice with alleviated pathology inflammation without systemic toxicity. This macrophage nanosystem synergizing increased efficiency defense may served therapeutics against TB.
Language: Английский
Citations
7
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 22, 2024
Gastric cancer (GC) is a malignant neoplasm originating from the epithelial cells of gastric mucosa. The pathogenesis GC intricately linked to tumor microenvironment within which reside. Tumor-associated macrophages (TAMs) primarily differentiate peripheral blood monocytes and can be broadly categorized into M1 M2 subtypes. M2-type TAMs have been shown promote growth, tissue remodeling, angiogenesis. Furthermore, they actively suppress acquired immunity, leading poorer prognosis reduced tolerance chemotherapy. Exosomes, contain myriad biologically active molecules including lipids, proteins, mRNA, noncoding RNAs, emerged as key mediators communication between TAMs. exchange these via exosomes markedly influence consequently impact progression. Recent studies elucidated correlation various clinicopathological parameters GC, such size, differentiation, infiltration depth, lymph node metastasis, TNM staging, highlighting pivotal role in development metastasis. In this review, we aim comprehensively examine bidirectional TAMs, implications alterations on immune escape, invasion, metastasis targeted therapeutic approaches for efficacy potential drug resistance strategies.
Language: Английский
Citations
6
Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155521 - 155521
Published: March 8, 2024
Language: Английский
Citations
6
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: May 2, 2024
Abstract The enhanced permeability and retention (EPR) effect has become the guiding principle for nanomedicine against cancer a long time. However, several biological barriers severely resist therapeutic agents’ penetration into deep tumor tissues, resulting in poor EPR high mortality. Inspired by lava, we proposed proteolytic enzyme therapy to improve distribution of nanomedicine. A trypsin-crosslinked hydrogel (Trypsin@PSA Gel) was developed maintain trypsin’s activity. postponed self-degradation sustained release. Trypsin promoted cellular uptake nanoformulations breast cells, through endothelial degraded total membrane proteins. Proteomic analysis reveals that trypsin affected ECM components down-regulated multiple pathways associated with progression. Intratumoral injection Trypsin@PSA Gel significantly increased liposomes tumors reduced vasculature. Combination treatment intravenous gambogic acid-loaded intratumoral inhibited growth. current study provides one first investigations induced novel therapy. Graphic
Language: Английский
Citations
6
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(45)
Published: July 11, 2024
Abstract The field of drug delivery has significantly advanced tumor therapy, yet challenges such as the predictability treatment outcomes and real‐time monitoring progression, recurrence or metastasis. Luminescent metal–organic frameworks (L‐MOFs) are a promising solution to overcome these issues. This review offers comprehensive exploration design synthesis L‐MOFs, presenting their crucial optical properties. highlights pivotal role L‐MOFs in enabling precision medicine for driven by performance. Through strategically harnessing light‐manipulated (MOFs), therapeutic precise spatiotemporal control can be achieved. Moreover, this meticulously examines influence photomanipulating MOFs on situ synthesis, introducing catalytic gas therapy. Additionally, gene therapy vectors that utilize light trigger expression responses is also comprehensively explored article, aiming highlight through concludes proposing an artificial intelligence (AI)‐mediated blueprint with pave way innovative approaches manipulation.
Language: Английский
Citations
6
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: June 21, 2024
Abstract In oncological nanomedicine, overcoming the dual‐phase high interstitial pressure in tumor microenvironment is pivotal for enhancing penetration and efficacy of nanotherapeutics. The elevated solid (TISP) largely attributed to overaccumulation collagen extracellular matrix, while increased fluid (TIFP) stems from accumulation due aberrant vascular architecture. this context, metal–organic frameworks (MOFs) with catalytic efficiency have shown potential degrading components, thereby reducing pressure. However, biotoxicity organic components MOFs limits their clinical translation. To circumvent this, a MOF‐like photocatalytic nanozyme, RPC@M, using naturally derived cobalt phytate (CoPA) resveratrol (Res) developed. This nanozyme not only facilitates decomposition water interstitium under photoactivation reduce TIFP, but also generates an abundance reactive oxygen species through its peroxidase‐like activity exert cytotoxic effects on cells. Moreover, Res contributes reduction deposition, lowering TISP. concurrent diminution both TISP TIFP by RPC@M leads enhanced potent antitumor activity, presenting innovative approach constructing therapeutic nanozymes natural products.
Language: Английский
Citations
5
Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)
Published: Aug. 1, 2024
Abstract Surgery remains the standard treatment for spinal metastasis. However, uncontrolled intraoperative bleeding poses a significant challenge adequate surgical resection and compromises outcomes. In this study, we develop thrombin (Thr)-loaded nanorobot-hydrogel hybrid superstructure by incorporating nanorobots into regenerated silk fibroin nanofibril hydrogels. This with superior thixotropic properties is injected percutaneously dispersed metastasis of hepatocellular carcinoma (HCC) easy characteristics, before surgery in mouse model. Under near-infrared irradiation, self-motile penetrate deep tumor, releasing Thr controlled manner. Thr-induced thrombosis effectively blocks tumor vasculature reduces bleeding, inhibiting growth postoperative recurrence Au nanorod-mediated photothermal therapy. Our minimally invasive platform provides novel preoperative therapeutic strategy HCC controlling growth, potentially reduced complications enhanced operative
Language: Английский
Citations
4
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 205 - 205
Published: Feb. 6, 2025
Cancer represents a significant societal, public health, and economic challenge. Conventional chemotherapy is based on systemic administration; however, it has current limitations, including poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, the development of multiple drug resistance. These factors underscore need for innovative strategies to enhance delivery directly tumours. However, local treatment also presents challenges, penetration through endothelial layers, tissue density in tumour microenvironment, interstitial fluid pressure, physiological conditions within tumour, permanence at site action. Nanotechnology promising alternative addressing these challenges. This narrative review elucidates potential nanostructured formulations cancer treatment, providing illustrative examples an analysis advantages challenges associated with this approach. Among nanoformulations developed breast, bladder, colorectal, oral, melanoma cancer, polymeric nanoparticles, liposomes, lipid nanohydrogels have demonstrated particular efficacy. systems permit mucoadhesion enhanced penetration, thereby increasing concentration (bioavailability) consequently improving anti-tumour efficacy potentially reducing effects. In addition studies indicating chemotherapy, nanocarriers can be used as theranostic approach combination irradiation methods.
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101583 - 101583
Published: Feb. 16, 2025
The application of Nanocarriers (NCs) provides a promising strategy to solve the problems faced by traditional chemotherapy drugs, like imprecise delivery, poor bioavailability, high dose requirement, and tendency develop multidrug resistance. With protection NCs, drugs can reach lesion site then release accurately completely. Although some reviews have summarized biological applications little attention has been given advantages disadvantages analyzing organic, inorganic, hybrid NCs separately for targeted therapy identifying means further improve targeting ability. First, in this review, we emphasize three factors that marked impact on therapy: tumor microenvironment (TME), different administration modalities (intravenous, oral, intracavitary administration), pathways (passive active). Second, systematic examination polymeric dendrimers, micelles, liposomes, mesoporous silica gold quantum dots, nano clay, core-shell MOFs are reviewed. Further, propose ways efficiency therapy, including regulating size, shape, surface properties NCs.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 307, P. 141501 - 141501
Published: March 5, 2025
Language: Английский
Citations
0