International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124973 - 124973
Published: Nov. 1, 2024
Language: Английский
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 297 - 297
Published: Feb. 20, 2024
Prostate cancer is one of the most life-threatening disorders that occur in males. It has now become third common disease all over world, and emerging cases spiking mortality rates are becoming more challenging day by day. Several approaches have been used to treat prostate cancer, including surgery, radiation therapy, chemotherapy, etc. These painful invasive ways treatment. Primarily, chemotherapy associated with numerous drawbacks restricting its further application. The majority cancers potential castration-resistant. cells exhibit resistance radiation, ADT (androgen-deprivation therapy) resistance, immune stiffness as a result activating tumor-promoting signaling pathways developing various treatment modalities. Nanomedicines such liposomes, nanoparticles, branched dendrimers, carbon nanotubes, quantum dots promising management techniques this context. can target drugs site enhance drug’s action for prolonged period. They may also increase solubility bioavailability poorly soluble drugs. This review summarizes current data on nanomedicines prevention cancer. Thus, nanomedicine pioneering management.
Language: Английский
Citations
8
Small, Journal Year: 2025, Volume and Issue: unknown
Published: April 24, 2025
Abstract The design and construction of synthetic therapeutic protocells capable engaging in high‐order assembly with living cells represent a significant challenge biology bioengineering. Inspired by cell membrane receptor‐ligand systems, protocell bioreactor is developed for targeted cancer elimination. This achieved constructing orthogonal, polysaccharide‐based (polysaccharidosomes, P‐somes) through bottom‐up approach that leverages host‐guest chemistry. are assembled via electrostatically‐driven self‐assembly β ‐cyclodextrin ( ‐CD)‐modified amino‐dextran on sacrificial template encapsulating glucose oxidase (GOx). To enable specific targeting catalytic activity, cell‐targeting ligands (arginylglycylaspartic acid, cRGD) catalase‐like platinum‐gold nanoparticles (Pt‐AuNPs) introduced interactions, forming fully functional, cell‐targeting, bio‐catalytic killer protocell. These programmed to spatially couple the GOx/Pt‐AuNP reaction cascade. In presence hydroxyurea, this cascade generates localized flux nitric oxide (NO), which exploited vitro inhibition. Overall, results highlight potential integrating orthogonal synergistic tumor inhibition mechanisms within microcompartments. platform demonstrates promise future applications, especially treatment, represents step forward development programmable protocell‐based systems.
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113704 - 113704
Published: April 1, 2025
Language: Английский
Citations
0
Molecules, Journal Year: 2024, Volume and Issue: 29(16), P. 3970 - 3970
Published: Aug. 22, 2024
To synthesize an effective and versatile nano-platform serving as a promising carrier for controlled drug delivery, visible-light-induced diselenide-crosslinked polyurethane micelles were designed prepared ROS-triggered on-demand doxorubicin (DOX) release. A rationally amphiphilic block copolymer, poly(ethylene glycol)-b-poly(diselenolane diol-co-isophorone diisocyanate)-b-poly(ethylene glycol) (PEG-b-PUSe-b-PEG), which incorporates dangling diselenolane groups within the hydrophobic PU segments, was initially synthesized through polycondensation reaction. In aqueous media, this type of copolymer can self-assemble into micellar aggregates encapsulate DOX core, forming DOX-loaded that are subsequently in situ core-crosslinked by diselenides via visible-light-triggered metathesis reaction Se-Se bonds. Compared with non-crosslinked (NCLMs), as-prepared (CLMs) exhibited smaller particle size improved colloidal stability. vitro release studies have demonstrated suppressed behavior CLMs physiological conditions, compared to NCLMs, whereas burst occurred upon exposure oxidation environment. Moreover, MTT assay results revealed crosslinked displayed no significant cytotoxicity towards HeLa cells. Cellular uptake analyses suggested internalization cancer These findings suggest kind reversibly hold potential ROS-responsive delivery system.
Language: Английский
Citations
2
Biomacromolecules, Journal Year: 2024, Volume and Issue: 26(1), P. 33 - 42
Published: Dec. 12, 2024
Bioresponsive polymeric nanoparticles (NPs) that are capable of delivering and releasing therapeutics biotherapeutics to target sites have attracted vivid interest in cancer therapy immunotherapy. In contrast enthusiastic evolution the academic world, clinical translation these smart systems is scarce, partly due concerns about safety, stability, complexity, scalability. The moderate targetability, responsivity, benefits other concerns. past 17 years, we devoted ourselves exploring elegant strategies address above basic translational problems by introducing diverse functional groups and/or targeting ligands safe biomedical materials, such as biodegradable polymers water-soluble polymers. This minimal modification critical for further translation. We tailor-made various bioresponsive NPs including shell-sheddable acid-sensitive NPs, disulfide-cross-linked micelles polymersomes, blood–brain barrier (BBB)-permeable different tumors. perspective provides an overview our work path toward targeted nanomedicines personalized vaccines, which might inspire future research on therapy.
Language: Английский
Citations
2
ACS Macro Letters, Journal Year: 2024, Volume and Issue: 13(11), P. 1433 - 1441
Published: Oct. 9, 2024
Polymeric nanocarriers have attracted significant attention in the field of anticancer drug delivery due to their unique advantages. However, designing that can maintain stability bloodstream while achieving specific release within tumor cells remains a major challenge. To address this issue, constructing reversible cross-linked polymeric are sensitive intracellular reducible glutathione (GSH) characteristic microenvironment is promising strategy. Based on this, we designed and synthesized two novel six-membered bicyclic carbonate monomers containing disulfide (DSBC) trisulfide (TSBC) bonds. Through one-step ring-opening polymerization, series reduction-sensitive polycarbonate copolymers (i.e., PEG-PDSBC PEG-PTSBC) were prepared, doxorubicin (DOX)-loaded nanoparticles fabricated using nanoprecipitation method. The
Language: Английский
Citations
1
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 664, P. 124580 - 124580
Published: Aug. 13, 2024
Language: Английский
Citations
0
Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 107816 - 107816
Published: Sept. 1, 2024
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124973 - 124973
Published: Nov. 1, 2024
Language: Английский
Citations
0