Poly-ε-caprolactone/chitosan/Whitlockite Electrospun Bionic Membrane conjugated with an E7 peptide for bone regeneration DOI Creative Commons
Guangzi Chen, Tao Xu, Ran Gao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Abstract Background: Periosteum plays an important role in bone defect repair due to its rich vascular network and cells. However, natural periosteum is difficult meet clinical requirements low availability. Therefore, it necessary develop a tissue engineering strategy of biomimetic for repair. Methods: Poly-ε-caprolactone/chitosan/Whitlockite electrospun bionic membrane (PCL/CS/WH) was prepared using electrospinning technology, then conjugated with E7 peptide as PCL/CS/WH/E7 membrane. The physical properties the membranes were evaluated by TEM FTIR. In vitro, LIVE/DEAD staining Cell Counting Kit-8 assay marrow mesenchymal stem cells (BMSCs) Endothelial progenitor (EPCs) are used assess biocompatibility membranes. Matrigel applied evaluate ability different composite nanofibers samples promote angiogenesis. Mineralized nodule collagen formation BMSCs detected alizarin red sirius respectively. vivo, regeneration angiogenesis assessed Micro-CT associated staining. Result: The addition chitosan (CS) (E7) enhanced hydrophilicity cytocompatibility pure PCL Additionally, CS, Mg2+ released from Whitlockite (WH) had synergistic effect osteogenic differentiation. Three weeks after implantation, successfully bridged significantly promoted new blood vessels. Concultion: achieve efficient enriches solutions treatment critical defects.

Language: Английский

Global Advancements in Bioactive Material Manufacturing for Drug Delivery: A Comprehensive Study DOI Creative Commons
Rafael Leandro Fernandes Melo, Dayana Nascimento Dari, Francisco Izaias da Silva Aires

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(1), P. 1207 - 1225

Published: Jan. 3, 2025

Manufacturing bioactive materials for drug delivery involves developing that interact with biological tissues to release drugs in a controlled and targeted manner. The goal is optimize therapeutic efficacy reduce side effects by combining knowledge from engineering, biology, pharmacology. This study presents detailed bibliometric analysis, exploring the keywords "manufacturing," "bioactive materials," "drug delivery" identify highlight significant advancements field. From Web of Science, 36,504 articles were analyzed, 171 selected deeper identifying key journals, countries, institutions, authors. results field's interdisciplinary nature, grouped into four main themes, including regenerative medicine, scaffolds, three-dimensional (3D) printing, glass, tissue engineering. Future research this area will focus on more effective precise systems using technologies like 3D printing nanotechnology enhance customization control release, aiming efficient therapies.

Language: Английский

Citations

6
Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies DOI Creative Commons
Xiaocui Chen, Zhuowen Hao, Hanke Li

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(10), P. 3859 - 3899

Published: Jan. 1, 2024

Osteoporosis is a systemic skeletal disease caused by an imbalance between bone resorption and formation. Current treatments primarily involve medication hormone therapy. However, these lack directionality are often ineffective for locally severe osteoporosis, with the potential complex adverse reactions. Consequently, treatment strategies using bioactive materials or external interventions have emerged as most promising approaches. This review proposes twelve microenvironmental targets osteoporosis-related pathological changes, including local accumulation of inflammatory factors reactive oxygen species (ROS), mitochondrial dynamics, insulin resistance, disruption cell autophagy, apoptosis, changes in neural secretions, aging cells, increased tissue vascular destruction, decreased regeneration. Additionally, this examines current research status effective biophysical biochemical stimuli based on summarizes advantages optimal parameters different bioengineering to support preclinical clinical osteoporosis Finally, addresses ongoing challenges future prospects.

Language: Английский

Citations

14
Unraveling the role of calcium in the osteogenic behavior of mesoporous bioactive glass nanoparticles DOI Creative Commons

José C García-Perdiguero,

Natividad Gómez‐Cerezo, Miguel Gisbert-Garzarán

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

1
Evaluation of Silica and Bioglass Nanomaterials in Pulp-like Living Materials DOI
Daline Mbitta Akoa,

Anthony Avril,

Christophe Hélary

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Although silicon is a widespread constituent in dental materials, its possible influence on the formation and repair of teeth remains largely unexplored. Here, we studied effect two silicic acid-releasing nanomaterials, silica bioglass, living model pulp consisting stem cells seeded dense type I collagen hydrogels. Silica nanoparticles released acid had little cell viability mineralization efficiency but impacted metabolic activity, delayed matrix remodeling, led to heterogeneous distribution. Bioglass improved activity homogeneous dispersion mineral deposits within hydrogel. These results suggest that presence calcium ions bioglass not only favorable proliferation can also counterbalance negative effects silicon. Both chemical biological processes should therefore be considered when investigating silicon-containing materials tissues.

Language: Английский

Citations

0
Lipid peroxidation inhibition by icaritin and its glycosides as a strategy to combat iron overload-induced osteoporosis in zebrafish DOI
Chang‐Yu Yan,

Xiao‐yuan Gu,

Si Tan

et al.

Food Research International, Journal Year: 2025, Volume and Issue: 203, P. 115900 - 115900

Published: Feb. 1, 2025

Language: Английский

Citations

0
Fabrication of novel cross-linker-free chitosan/ BIBLIOGRAPHY \l 16393 strontium bioglass composite for wound healing application DOI

A. Sivalingam,

Ramana Ramya Jayapalan,

M. Sampath

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142532 - 142532

Published: March 1, 2025

Language: Английский

Citations

0
Nanominerals: a multifaceted biomaterial for regenerative medicine and drug delivery DOI
Aishik Chakraborty, Wei Luo, Amauri J. Paula

et al.

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

Citations

0
Impact of Vitamin D3 Functionalization on the Osteogenic Capacity of Bioinspired 3D Scaffolds Based on Ce-Doped Bioactive Glass and Spongia Agaricina DOI Creative Commons
Ana-Maria Seciu-Grama,

S. Lazar,

Simona Petrescu

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(4), P. 141 - 141

Published: April 14, 2025

Reconstruction of extensive bone defects due to age, trauma, or post-illness conditions remains challenging. Biomimetic scaffolds with osteogenic capabilities have been proposed as an alternative the classical autograft and allograft implants. Three-dimensional were obtained based on Ce-doped mesoporous bioactive glass (MBG) Spongia agaricina (SA) sacrificial templates functionalized vitamin D3. The study aimed investigate effect D3 functionalization optimal variant a 3D scaffold doped 3 mol% ceria, selected in our previous work its biological physicochemical properties. Scanning electron microscopy (SEM) images non-functionalized/functionalized revealed porous structure interconnected pores ranging from 100 350 μm. Fourier transform infrared spectroscopy (FTIR) SEM analysis confirmed surface functionalization. Cytotoxicity evaluation showed that all investigated do not exhibit cytotoxicity genotoxicity toward Saos-2 osteosarcoma cell line. Moreover, demonstrated enhanced activity dental pulp stem cells (DPSCs) by increasing calcium deposition osteocalcin secretion, determined Alizarin red stain colorimetric ELISA kit, result synergistic action cerium ions. results MBG had potential for applications regeneration.

Language: Английский

Citations

0
Insight into bioactive glass and bio-ceramics uses: unveiling recent advances for biomedical application DOI Creative Commons
Doha El‐Sayed Ellakwa,

Ahmad S. Abu‐Khadra,

Takwa E. Ellakwa

et al.

Discover Materials, Journal Year: 2025, Volume and Issue: 5(1)

Published: April 25, 2025

Language: Английский

Citations

0
Emerging Technologies to Enhance Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells: Focus on Nanomaterials and Bioactive Compounds DOI

Ziyi Ling,

Han Yang, Shuhong Zhang

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Bone tissue damage and associated disorders significantly compromise the quality of life affected patients, existing therapeutic options remain limited. marrow mesenchymal stem cells (BMSCs) play a crucial role in bone regenerative medicine, owing to their ability differentiate into osteoblasts. Utilizing cutting-edge technologies, nanomaterials, bioactive compounds can emulate natural microenvironment, offer three-dimensional scaffold that facilitates osteogenic differentiation BMSCs, modulate signals at molecular level, thereby showing promise for applications regeneration repair. This review seeks discuss latest research advancements, elucidate underlying mechanisms, highlight potential benefits these technologies augmenting capacity BMSCs. Furthermore, challenges future directions integrating practical settings are discussed pioneer new vistas medicine.

Language: Английский

Citations

0