Enzalutamide inhibits PEX10 function and sensitizes prostate cancer cells to ROS activators DOI Creative Commons
Yuankang Feng, Yu Zhang, Hao Li

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(8)

Published: Aug. 3, 2024

Sharply increased reactive oxygen species (ROS) are thought to induce oxidative stress, damage cell structure and cause death; however, its role in prostate cancer remains unclear. Enzalutamide is a widely used anti-prostate drug that antagonizes androgen binding with receptor. Further exploration of the mechanism potential application strategies enzalutamide crucial for treatment cancer. Here, we confirmed PEX10 can be induced by ROS activators while reduce level cells, which weakened anti-tumor effect activators. The receptor (AR) promote expression acting as an enhancer cooperation FOXA1. inhibits inhibiting function AR, synergize ML210 or RSL3 produce stronger effect, thereby sensitizing cells This study reveals previously unrecognized AR regulating suggests new strategy treatment.

Language: Английский

Bi‐Pt Heterojunction Cascade Reaction Platform for Sono‐Immunotherapy of Tumors via PANoptosis and Ferroptosis DOI
Sijia Wu, Qian Wang, Junhui Du

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Abstract Sonodynamic therapy (SDT) represents a promising, noninvasive, and precise treatment modality for tumors, demonstrating significant potential in clinical applications. However, the efficiency of sonosensitizers generating reactive oxygen species (ROS) is often limited by rapid electron‐hole recombination. In this study, BiF 3 @BiOI synthesized via co‐precipitation method, followed in‐situ reduction to decorate it with Pt nanoparticles, resulting @BiOI@Pt‐PVP (BBP) nanocomposite enhancing SDT efficacy. The formation heterojunction enhances charge separation ability. decoration nanoparticles narrows bandgap alters band positions Fermi level BBP, which can effectively mitigate recombination pairs facilitate cascade reaction ROS, thereby improving ROS generation ultrasound excitation. Additionally, bismuth ions BBP generated holes consume glutathione, exacerbating cellular oxidative damage, triggering PANoptosis ferroptosis. Furthermore, demonstrate peroxidase‐like activity, catalyzing endogenous hydrogen peroxide oxygen. These functions are helpful against tumors alleviating hypoxic conditions, reshaping microenvironment, modulating immune cell infiltration capacity, efficacy immunotherapy. dual strategy forming heterojunctions sensitization noble metals sono‐catalytic therapy‐induced activation tumor treatment.

Language: Английский

Citations

9
Convertible ROS Nanogenerator/Eliminator for Enhanced Tumor Photothermal Therapy with Reduced Inflammatory Response DOI Open Access

Houren Zhou,

Xinyu Zhang, Hui Liu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Abstract Photothermal therapy (PTT), as an innovative optical tumor treatment strategy, is characterized by its minimal invasiveness, high selectivity, long‐lasting efficacy, and safety, has attracted widespread attention. However, in order to effectively kill cancer cells, a higher local temperature very necessary, which inevitably results severe stress responses cell death, thereby triggering harmful inflammation. Additionally, achieving effective controlled release of drugs the microenvironment reduce systemic side effects still major challenge. Herein, intelligent nanoplatform first reported, featured sulfide iron (FeS) nanosheets core, loaded with perfluorohexane (PFH), skillfully coated polydopamine (PDA). It can serve generator reactive oxygen species (ROS) induce ferroptosis, further intensifying PTT, ROS eliminator normal tissue control undesired inflammatory response during differential strategy between surrounding tissue. Meanwhile, combination ultrasound‐targeted microbubble destruction (UTMD) technology significantly enhanced penetration drug. Overall, delivery FeS/PFH@PDA combined UTMD achieve precise efficient synergistic for tumors demonstrate outstanding ultrasound MR dual‐mode imaging performance.

Language: Английский

Citations

1
Implications of nanotherapeutic advancements to leverage multi-drug resistant breast cancer: The state-of-the-art review DOI Creative Commons

Adhithya Aravindan,

Ashutosh Gupta, Sudheer Moorkoth

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 100, P. 106007 - 106007

Published: Aug. 5, 2024

Globally, cancer is regarded as a severe health issue. Among these breast (BC), the second most common kind in women after skin cancer. According to statistical data from NIH Cancer Institute, expected number of cases was around 3 lakh people, with 7.1 % fatality rate. The rise multidrug resistance (MDR) British Columbia issue it lowers effectiveness existing treatments. Traditional MDR treatment approaches BC have drawbacks, including toxicity, high cost, early discharge, restricted drug load before target, and poor effectiveness. Preventing has depended heavily on developing innovative therapy delivery methods utilizing nanomedicine new diagnosing treating BC. This review discusses its pathophysiology relation tumor kinetics. It focuses latest therapeutic over traditional like Surgery, Chemotherapy, Nanomedicine, Phototherapy, Immunotherapy, Gene therapy. also describes diagnostic techniques using MRI/PET, Mammography, Microwave Sensing, In-silico methods, Molecular techniques, AI-machine learning-based tools. discussed limitations nanoparticles article aims identify efficient ways diagnose treat prevent recurrence.

Language: Английский

Citations

8
Recent advances of piezoelectric materials used in sonodynamic therapy of tumor DOI

Hsin-I Huang,

Yuqing Miao, Yuhao Li

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 523, P. 216282 - 216282

Published: Oct. 22, 2024

Language: Английский

Citations

8
Advances in Nanodynamic Therapy for Cancer Treatment DOI Creative Commons
Bingchang Zhang, Yan Huang, Yong Huang

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(7), P. 648 - 648

Published: April 8, 2024

Nanodynamic therapy (NDT) exerts its anti-tumor effect by activating nanosensitizers to generate large amounts of reactive oxygen species (ROS) in tumor cells. NDT enhances tumor-specific targeting and selectivity leveraging the microenvironment (TME) mechanisms that boost immune responses. It also minimizes damage surrounding healthy tissues cytotoxicity cells, showing promise cancer treatment, with significant potential. This review covers research progress five major nanodynamic therapies: photodynamic (PDT), electrodynamic (EDT), sonodynamic (SDT), radiodynamic (RDT), chemodynamic (CDT), emphasizing role advanced nanotechnology development for purposes. The mechanisms, effects, challenges faced these NDTs are discussed, along their respective solutions enhancing efficacy, such as pH response, delivery, combined immunotherapy. Finally, this briefly addresses clinical translation NDT.

Language: Английский

Citations

7
Charge Separation‐Engineered Piezoelectric Ultrathin Nanorods Modulate Tumor Stromal Microenvironment and Enhance Cell Immunogenicity for Synergistically Piezo‐Thermal‐Immune Therapy DOI
Qian Wang, Junhui Du,

Fujun Yang

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 16, 2024

Abstract The tumor microenvironment (TME) is characterized by hypoxia and low immunogenicity, with a dense rigid extracellular matrix (ECM) that impedes the diffusion of therapeutic agents immune cells, thereby limiting efficacy immunotherapy. To overcome these challenges, an oxygen defect piezoelectric‐photothermal sensitizer, bismuth vanadate nanorod‐supported platinum nanodots (BVP) developed. integration enhances photothermal effect improves charge separation efficiency under ultrasound, leading to increased heat generation production reactive species (ROS) oxygen. Platinum also catalyzes conversion hydrogen peroxide in TME oxygen, which serves as both ROS source means alleviate hypoxia, reversing immunosuppressive TME. Moreover, coordination ions glutathione further amplifies cellular oxidative stress. generated not only denature collagen ECM, facilitating deeper penetration BVP into but induce immunogenic cell death cells. Through “degeneration penetration” strategy, photoacoustic therapy effectively activates inhibiting growth metastasis. This study introduces pioneering approach design antitumor nanomedicines aimed at characteristics

Language: Английский

Citations

5
Emerging Piezoelectric Sonosensitizer for ROS-Driven Sonodynamic Cancer Therapy DOI Creative Commons
Guiyun Wang,

Yanxia Qi,

Zhuang Liu

et al.

Inorganics, Journal Year: 2025, Volume and Issue: 13(3), P. 71 - 71

Published: Feb. 26, 2025

As a non-invasive modality, sonodynamic therapy (SDT) offers several advantages in cancer treatment, including deep tissue penetration and precise spatiotemporal control, resulting from the interplay between low-intensity ultrasound sonosensitizers. Piezoelectric materials, known for their remarkable capacity of interconversion mechanical electrical energy, have garnered considerable attention biomedical applications, which can serve as pivotal sonosensitizers SDT. These materials generate internal electric fields via ultrasound-induced deformation, modulates alteration charge carriers, thereby initiating surface redox reactions to reactive oxygen species (ROS) realizing therapeutic efficacy This review provides an in-depth exploration piezoelectric utilized SDT, with particular emphasis on recent innovations, elucidation underlying mechanisms, optimization strategies advanced materials. Furthermore, incorporation immunotherapy, photodynamic, chemodynamic, chemotherapy is explored, emphasizing potential enhance outcomes. By examining basic principles effect its contributions this sheds light promising applications oncology. It also highlights future directions improving these expanding clinical utility tumor therapy.

Language: Английский

Citations

0
Safe-by-design strategies towards bismuth-based nanomaterials in tumor diagnosis and therapy DOI
Xiaoyu Zhang,

Fene Gao,

Yizhi Dai

et al.

Nano Today, Journal Year: 2025, Volume and Issue: 62, P. 102714 - 102714

Published: March 15, 2025

Language: Английский

Citations

0
Enzalutamide inhibits PEX10 function and sensitizes prostate cancer cells to ROS activators DOI Creative Commons
Yuankang Feng, Yu Zhang, Hao Li

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(8)

Published: Aug. 3, 2024

Sharply increased reactive oxygen species (ROS) are thought to induce oxidative stress, damage cell structure and cause death; however, its role in prostate cancer remains unclear. Enzalutamide is a widely used anti-prostate drug that antagonizes androgen binding with receptor. Further exploration of the mechanism potential application strategies enzalutamide crucial for treatment cancer. Here, we confirmed PEX10 can be induced by ROS activators while reduce level cells, which weakened anti-tumor effect activators. The receptor (AR) promote expression acting as an enhancer cooperation FOXA1. inhibits inhibiting function AR, synergize ML210 or RSL3 produce stronger effect, thereby sensitizing cells This study reveals previously unrecognized AR regulating suggests new strategy treatment.

Language: Английский

Citations

1