Engineering of calcium overload for state-of-the-art tumor therapy DOI
Xinping Liu, Hui Hu, Jinjin Chen

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 501, P. 157747 - 157747

Published: Nov. 17, 2024

Language: Английский

CX3CL1 (Fractalkine)-CX3CR1 Axis in Inflammation-Induced Angiogenesis and Tumorigenesis DOI Open Access
Dariusz Szukiewicz

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4679 - 4679

Published: April 25, 2024

The chemotactic cytokine fractalkine (FKN, chemokine CX3CL1) has unique properties resulting from the combination of chemoattractants and adhesion molecules. soluble form (sFKN) strongly attracts T cells monocytes. membrane-bound (mFKN) facilitates diapedesis is responsible for cell-to-cell adhesion, especially by promoting strong leukocytes (monocytes) to activated endothelial with subsequent formation an extracellular matrix angiogenesis. FKN signaling occurs via CX3CR1, which only known member CX3C receptor subfamily. Signaling within FKN-CX3CR1 axis plays important role in many processes related inflammation immune response, often occur simultaneously overlap. upregulated hypoxia and/or inflammation-induced inflammatory release, it may act locally as a key angiogenic factor highly hypoxic tumor microenvironment. importance FKN/CX3CR1 pathway tumorigenesis cancer metastasis results its influence on cell apoptosis, migration. This review presents context angiogenesis cancer. mechanisms determining pro- or anti-tumor effects are presented, cause seemingly contradictory that create confusion regarding therapeutic goals.

Language: Английский

Citations

15
Natural-product-based, carrier-free, noncovalent nanoparticles for tumor chemo-photodynamic combination therapy DOI Creative Commons
Zhonglei Wang, Liyan Yang

Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107150 - 107150

Published: March 21, 2024

Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global morbidity, disability, mortality, highlighting the necessity for transformative treatment approaches. Photodynamic therapy (PDT) has aroused continuous interest as viable alternative conventional cancer treatments that encounter drug resistance. Nanotechnology brought new advances in medicine shown great potential delivery treatment. For precise efficient therapeutic utilization of such tumor approach high spatiotemporal selectivity minimal invasiveness, carrier-free noncovalent nanoparticles (NPs) based on chemo-photodynamic combination essential. Utilizing natural products foundation nanodrug development offers unparalleled advantages, including exceptional pharmacological activity, easy functionalization/modification, well biocompatibility. The natural-product-based, carrier-free, NPs revealed excellent synergistic anticancer activity comparison free photosensitizers bioactive products, representing an favorable avenue improve efficacy. Herein, comprehensive summary current strategies representative application examples past decade (such paclitaxel, 10-hydroxycamptothecin, doxorubicin, etoposide, combretastatin A4, epigallocatechin gallate, curcumin) therapy. We highlight insightful design synthesis smart aim enhance PDT Meanwhile, we discuss future challenges opportunities associated these provide enlightenment, spur innovative ideas, facilitate PDT-mediated clinical transformation.

Language: Английский

Citations

13
Chimeric Antigen Receptor Cell Therapy: Empowering Treatment Strategies for Solid Tumors DOI Creative Commons
Tang‐Her Jaing, Yi-Wen Hsiao, Yi-Lun Wang

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 90 - 90

Published: Jan. 31, 2025

Chimeric antigen receptor-T (CAR-T) cell therapy has demonstrated impressive efficacy in the treatment of blood cancers; however, its effectiveness against solid tumors been significantly limited. The differences arise from a range difficulties linked to tumors, including an unfriendly tumor microenvironment, variability within and barriers CAR-T infiltration longevity at location. Research shows that reasons for decreased cells treating are not well understood, highlighting ongoing need strategies address these challenges. Current frequently incorporate combinatorial therapies designed boost functionality enhance their capacity effectively target tumors. However, remain testing phase necessitate additional validation assess potential benefits. CAR-NK (natural killer), CAR-iNKT (invariant natural killer T), CAR-M (macrophage) emerging as promising Recent studies highlight construction optimization cells, emphasizing overcome unique challenges posed by such hypoxia metabolic barriers. This review focuses on CAR

Language: Английский

Citations

0
Construction of nitroreductase-responsive near-infrared composite nanoprobe and its application in tumor hypoxia imaging DOI
Ying Chen,

Guanglian Zhou,

Yitong Li

et al.

Talanta, Journal Year: 2025, Volume and Issue: 289, P. 127750 - 127750

Published: Feb. 14, 2025

Language: Английский

Citations

0
sEmerging glucose oxidase-delivering nanomedicines for enhanced tumor therapy DOI

Kai‐Yue Song,

Ming Jiang, Bailong Tao

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 381, P. 113580 - 113580

Published: Feb. 28, 2025

Language: Английский

Citations

0
Preparation of 10B-enriched nitroimidazole derivative by click reaction as a functional drug for hypoxia-targeting boron-neutron capture therapy DOI Creative Commons

TERUAKI OZASA,

Masaaki MIZUTANI,

Tatsuya Nishihara

et al.

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102245 - 102245

Published: April 1, 2025

Language: Английский

Citations

0
Recent advances in polydopamine-coated metal–organic frameworks for cancer therapy DOI Creative Commons

Jingchao He,

Guangtian Wang, Yongfang Zhou

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 1, 2025

The creation and development of classical multifunctional nanomaterials are crucial for the advancement nanotherapeutic treatments tumors. Currently, metal–organic frameworks (MOFs) modified with polydopamine (PDA) at forefront nanomedicine research, particularly in tumor diagnostics therapy, owing to their exceptional biocompatibility, expansive specific surface area, multifaceted functionalities, superior photothermal properties, which led significant advancements anti-tumor research. Consequently, a range anti-cancer strategies has been devised by leveraging capabilities MOFs, including intelligent drug delivery systems, photodynamic tailored microenvironment. In order gain deeper insight into role MOFs@PDA cancer diagnosis treatment, it is essential conduct comprehensive review existing research outcomes promptly analyze challenges associated biological applications. This will provide valuable perspectives on potential clinical settings.

Language: Английский

Citations

0
A robust Metal–Organic Framework-Based nanozyme with Multienzyme-Like properties for synergistic tumor therapy via efficient and sustainable Nitric oxide generation DOI
Xinping Liu, Yi Li,

Jinjin Chen

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 693, P. 137603 - 137603

Published: April 15, 2025

Language: Английский

Citations

0
NTR rapidly activated photosensitizers for high-signal-to-noise imaging and type I photodynamic therapy DOI
Xingwei Li,

Jiahong Ai,

Yurong Zhang

et al.

Nano Today, Journal Year: 2025, Volume and Issue: 63, P. 102768 - 102768

Published: April 15, 2025

Language: Английский

Citations

0
Leveraging Large Language Models for Accelerated Learning and Innovation in Biogenic Tissue-Engineered Vascular Grafts DOI
Fernando Gomes de Souza,

Karine Velasco,

S. D. C. CUNHA

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106935 - 106935

Published: April 1, 2025

Language: Английский

Citations

0