Fmoc-FF Nanogel-Mediated Delivery of Doxorubicin and Curcumin in Thyroid Cancer Cells

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 263 - 263

Published: Feb. 17, 2025

Background: Thyroid cancer (TC) is the most prevalent endocrine malignancy, and categorized into well-differentiated aggressive anaplastic types. Novel therapeutic modalities are needed for TC. Nanomedicine a promising strategy development of precision medicine. In this context, we investigated use nanogels (NGs) to deliver agents with different physicochemical properties, specifically hydrophilic agent doxorubicin (DOX) hydrophobic compound curcumin (CUR), in TC cell lines. Methods: Nα-9-fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) peptide-based NGs loaded DOX CUR were formulated using solvent-switch method. DOX-loaded previously characterized. CUR-loaded characterized through rheology, scanning electron microscopy (SEM), dynamic light scattering (DLS), nanoparticle tracking analysis (NTA), Fourier transform infrared (FT-IR) spectroscopy. Confocal microscopy, q-RT-PCR, ATP lite assays performed evaluate uptake delivery DOX- on Results: exhibited mean diameter approximately 204.3 nm zeta potential -34.6 mV, indicative good stability. vitro release studies revealed sustained profile over 72 h. Functional analyses demonstrated that Fmoc-FF-loaded internalized They primarily localized cytoplasm rather than early endosomes, thereby ensuring intracellular Furthermore, Fmoc-FF reduced nuclear kinetics cells, suggesting reduction dose-limiting toxicity. Comparative similar internalization delayed uptake, highlighting efficacy delivering agents. Conclusions: Overall, data suggest represent diverse properties TC, enhancing their safety warranting further investigation.

Language: Английский

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Unveiling the Electrocatalytic Performances of the Pd-MoS2 Catalyst for Methanol-Mediated Overall Water Splitting

Inorganics, Journal Year: 2025, Volume and Issue: 13(1), P. 21 - 21

Published: Jan. 15, 2025

Herein, this work elucidates the synthesis of Pd-MoS2 catalyst for application in methanol-mediated overall water splitting. The scanning electron microscope (SEM) and transmission (TEM) pictures offer an exciting nanostructured shape Pd-MoS2, depicting a high surface area. Further, high-resolution TEM (HRTEM) confirm lattice plane (100), spacing (0.26 nm), hexagonal crystal structure Pd-MoS2. Moreover, high-angle annular dark-field (HAADF) images related color maps disclose Mo, S, Pd elements exhibits lower overpotentials 224.6 mV [methanol-mediated hydrogen evolution reaction (MM-HER)] at −10 mA cm−2 133 oxygen (MM-OER)] 10 cm−2. illustrates noteworthy stability 15.5 h MM-HER 18 MM-OER by chronopotentiometry test. Excitingly, Pd-MoS2∥Pd-MoS2 cell reveals small potential 1.581 V compared to MoS2∥MoS2 (1.648 V) In addition, combination brilliant durability over

Language: Английский

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Sustainable green synthesis of silver nanoparticles for safer biomedical application

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 115998 - 115998

Published: Feb. 1, 2025

Language: Английский

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Integration of molybdenum disulfide and phosphorene into polymeric-based nanocomposite hydrogels for various biomedical applications: Recent advances and future prospects

European Polymer Journal, Journal Year: 2024, Volume and Issue: 218, P. 113347 - 113347

Published: July 28, 2024

Language: Английский

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Enhanced chemodynamic porphyrin-modified magnetite nanoagents: A triple-action strategy for potent antimicrobial therapy and wound healing

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 687, P. 742 - 755

Published: Feb. 16, 2025

Language: Английский

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Exosomes/MoS2 complex for targeting and effective photothermal therapy

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Photothermal therapy (PTT) has been an attractive tumor treatment strategy in recent years. Two-dimensional molybdenum disulfide (MoS₂)-based nanomaterials with high photothermal efficiency is a critical candidate for PTT. However, the tumor-targeting capability extremely needs to be improved effective treatment. In this work, we combine MoS₂ nanodots exosomes, native vesicles secreted from living cells, construct novel exosomes/MoS₂ complex (MoS₂@ME) tumor-targeted Through ultrasonic self-assembly membranes, are incorporated into MCF-7 exosomes. Similar free MoS₂, MoS₂@ME shows significant conversion effect, causing nearly 100% necrosis proportion of and 4T1 cells under 1064 nm laser irradiation within 5 min (0.4 W/cm²) in vitro. particular, presents noteworthy affinity vivo studies further prove that it could accumulate at site efficiently. After intravenous injection plus NIR irradiation, temperature tumor-bearing mice reach 46°C short time (~ 2 min). Notably, prolongation time, tumors gradually increases reaches maximum (52.3°C) 8 min, which far higher than group. More importantly, PTT using exhibits much more antitumor therapy, as volume weight group significantly lower those PBS groups (P < 0.05), even disappears completely. In vitro demonstrate excellent targeting capacity achieving cancer therapy. This work expected overcome shortcomings some materials, aiming improve safety effectiveness. The exosome-incorporated design may pave new way molybdenum-based

Language: Английский

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Nanostructured materials for breast cancer therapeutics enhancing drug delivery through nanofibers, nano-mesh, and nanoflowers

Next Nanotechnology, Journal Year: 2025, Volume and Issue: 8, P. 100159 - 100159

Published: Jan. 1, 2025

Language: Английский

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Current progress and remaining challenges of peptide–drug conjugates (PDCs): next generation of antibody-drug conjugates (ADCs)?

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 22, 2025

Drug conjugates have emerged as a promising alternative delivery system designed to deliver an ultra-toxic payload directly the target cancer cells, maximizing therapeutic efficacy while minimizing toxicity. Among these, antibody-drug (ADCs) garnered significant attention from both academia and industry due their great potential for therapy. However, peptide-drug (PDCs) offer several advantages over ADCs, including more accessible industrial synthesis, versatile functionalization, high tissue penetration, rapid clearance with low immunotoxicity. These factors position PDCs up-and-coming drug candidates future Despite potential, face challenges such poor pharmacokinetic properties bioactivity, which hinder clinical development. How design meet needs is big challenge urgent resolve. In this review, we first carefully analyzed general consideration of successful PDC learning ADCs. Then, summarised basic functions each component construct, comprising peptides, linkers payloads. The peptides in were categorized into three types: tumor targeting cell penetrating peptide self-assembling peptide. We then these delivery, overcoming resistance, controlling release improving reduced non-specific To better understand druggability PDCs, discussed pharmacokinetics also briefly introduced current trials. Lastly, perspectives development oncology PDC. This review aimed provide useful information construction applications.

Language: Английский

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L-Kynurenine regulates immune response in ICIs-associated myocarditis via JAK/STAT pathway

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 156, P. 114676 - 114676

Published: April 22, 2025

Language: Английский

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NIR II light-driven nanomotor synergistically enhances immunogenic cell death through photothermal and chemodynamic therapy for melanoma immunotherapy

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 694, P. 137688 - 137688

Published: April 23, 2025

Language: Английский

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