Dexibuprofen loaded into nanoemulsion based gel for topical application; in vitro characterization and in vivo anti-inflammatory evaluation DOI

Rabia Munir,

Ikram Ullah Khan,

Yousaf Kamal

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 247, P. 114407 - 114407

Published: Nov. 26, 2024

Language: Английский

L-Kynurenine regulates immune response in ICIs-associated myocarditis via JAK/STAT pathway DOI
Xiaozhen He, Jian Zhang,

Yerui Zhang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 156, P. 114676 - 114676

Published: April 22, 2025

Language: Английский

Citations

0
Biomedical application of microalgal‐biomaterials hybrid system DOI
Yize Li,

Fan Ya-li,

Shuo Ye

et al.

Biotechnology Journal, Journal Year: 2024, Volume and Issue: 19(8)

Published: Aug. 1, 2024

Abstract Microalgae are a group of microorganisms containing chlorophyll A, which highly photosynthetic and rich in nutrients. And they can produce multiple bioactive substances (peptides, proteins, polysaccharides, fatty acids) for biomedical applications. Despite the unique advantages microalgae‐based biotherapy, insufficient treatment efficiency limits its further application. With development nanotechnology, combination microalgae biomaterials improve therapeutic efficacies, has attracted increasing attention. In this microalgal‐biomaterials hybrid system, with excellent optical magnetic properties play an important role biological therapy. Microalgae, as natural vehicle, increase oxygen content alleviate hypoxia diseased areas, enhancing effects. review, synergistic effects system different diseases (cancer, myocardial infarction, ischemia stroke, chronic infection, intestinal diseases) comprehensively summarized.

Language: Английский

Citations

2
Nanostructure-reinforced multifunctional hydrogels for synergistic cancer therapy DOI
Satar Yousefiasl, Mahsa Ghovvati,

Mojdeh Mirshafiei

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216207 - 216207

Published: Sept. 13, 2024

Language: Английский

Citations

2
Biomacromolecular hydrogel scaffolds from microfluidics for cancer therapy: A review DOI

Siyu Hao,

Linlin Shi,

Jun Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136738 - 136738

Published: Oct. 20, 2024

Language: Английский

Citations

2
Recent developments in two-dimensional molybdenum disulfide-based multimodal cancer theranostics DOI Creative Commons
Xinbo Yu, Xu Chen,

Jingxu Sun

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 28, 2024

Recent advancements in cancer research have led to the generation of innovative nanomaterials for improved diagnostic and therapeutic strategies. Despite proven potential two-dimensional (2D) molybdenum disulfide (MoS

Language: Английский

Citations

1
Investigation of oral toxicity of WS2 nanosheets to mouse intestine: Pathological injury, trace element balance, lipid profile changes, and autophagy DOI

Zhenghao Zha,

Sihuan Luo,

Lianghuan Wei

et al.

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 29, 2024

Abstract The success of graphene oxides has gained extensive research interests in developing novel 2D nanomaterials (NMs). WS 2 nanosheets (NSs) are transition metal‐based NMs, but their toxicity is unclear. In this study, we investigated the oral NSs to mouse intestines. Male mice were administrated with vehicles, 1, 10, or 100 mg/kg via intragastric route, once a day, for 5 days. results indicate that did not induce pathological ultrastructural changes There minimal trace elements exposure W accumulation, and only Co levels dose‐dependently increased. Lipid droplets observed all groups mice, lipidomics data significantly decreased four lipid species, belonging phosphatidylcholine (PC). proteins regulating autophagic lipolysis, namely, LC3, lysosomal associated membrane protein (LAMP2) perilipin (PLIN2), increased, it was statistically different LC3. study suggest repeated induced influences on injury, element balance, autophagy, profiles intestines, indicating relatively high biocompatibility intestine route.

Language: Английский

Citations

1
Enhanced Stability of α-Mangostin-Rich Extract and Selective Cytotoxicity against Cancer Cells via Encapsulation in Antioxidant Nanoparticles (AME@NanoAOX) DOI
Wiwit Suttithumsatid, Takuto Toriumi, Wanida Sukketsiri

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(8), P. 5027 - 5038

Published: July 18, 2024

α-Mangostin-rich extract (AME) shows promise as a functional ingredient for cancer chemotherapy. Here, we encapsulated AME in our originally designed antioxidant nanoparticles (NanoAOX) to increase its solubility and prevent oxidative degradation (AME@NanoAOX). In this study, two types of self-assembled polymers containing nitroxide radicals were engineered. These into nanoscale particles aqueous media, entrapping (abbreviated AME@NanoAOX(B) AME@NanoAOX(G)). formulations considerably improved the stability against exhibited different release profiles α-mangostin under pH conditions. Furthermore, AME-encapsulated potent cytotoxicity various cell lines, including human breast (MCF-7), lung (A549), colon (Caco-2), cervical (HeLa), liver (HepG2) with minimal normal mammary epithelial cells (hTERT-HME1), thus providing high selectivity index (SI). results indicated promising feature (AME@NanoAOX)

Language: Английский

Citations

0
Dexibuprofen loaded into nanoemulsion based gel for topical application; in vitro characterization and in vivo anti-inflammatory evaluation DOI

Rabia Munir,

Ikram Ullah Khan,

Yousaf Kamal

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 247, P. 114407 - 114407

Published: Nov. 26, 2024

Language: Английский

Citations

0