pH-Responsive Modified HAMA Microspheres Regulate the Inflammatory Microenvironment of Intervertebral Discs DOI Creative Commons
Tao Ma,

Jingwei Wu,

Senlin Chen

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(46), P. 63295 - 63305

Published: Nov. 12, 2024

Currently, intervertebral disc (IVD) degeneration is believed to lead local accumulation of lactic acid in the IVD, a decrease pH, activation inflammatory pathway, and continued destruction homeostasis IVD. To address these issues, intelligent accurate release drugs particularly important. In this study, acid-sensitive methacrylated hyaluronic (HAMA) microspheres were constructed by using microfluidic technology, which can be used as targeted drug delivery system for (IVDD) through Schiff base chemical bonding on surface achieve release. Interleukin-1 receptor antagonist (IL-1 Ra) naturally occurring anti-inflammatory interleukin-1 family pro-inflammatory cytokines. Despite its outstanding broad-spectrum effects, IL-1 Ra has short biological half-life (4–6 h). The slow-release performance greatly improved bovine serum albumin nanoparticles (BNP). addition, modified HAMA exhibited good injectability porosity, efficient uniform loading was achieved via bond. microenvironment significantly reversed transporting microspheres-BNPs (Modified MS) degenerative nucleus pulposus.

Language: Английский

Recent advances of sustained drug delivery system using droplet microfluidic platforms DOI

Haofan Liu,

Xiaomei Qiao,

Quanling Zhang

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106806 - 106806

Published: March 1, 2025

Language: Английский

Citations

0
Organoids in Dynamic Culture: Microfluidics and 3D Printing Technologies DOI
Xin Su, Mingqi Wang,

Ruqiang Yuan

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

With the rapid advancement of biomaterials and tissue engineering technologies, organoid research its applications have made significant strides. Organoids are increasingly utilized in pharmacology, regenerative medicine, precision clinical medicine. Current trends moving toward multifunctional composite three-dimensional cultivation dynamic strategies. Key technologies driving this evolution, including 3D printing microfluidics, continue to impact new areas discovery relevance. This review provides a systematic overview these emerging trends, discussing strengths limitations critical offering insight directions for professionals working field.

Language: Английский

Citations

0
pH-Responsive Modified HAMA Microspheres Regulate the Inflammatory Microenvironment of Intervertebral Discs DOI Creative Commons
Tao Ma,

Jingwei Wu,

Senlin Chen

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(46), P. 63295 - 63305

Published: Nov. 12, 2024

Currently, intervertebral disc (IVD) degeneration is believed to lead local accumulation of lactic acid in the IVD, a decrease pH, activation inflammatory pathway, and continued destruction homeostasis IVD. To address these issues, intelligent accurate release drugs particularly important. In this study, acid-sensitive methacrylated hyaluronic (HAMA) microspheres were constructed by using microfluidic technology, which can be used as targeted drug delivery system for (IVDD) through Schiff base chemical bonding on surface achieve release. Interleukin-1 receptor antagonist (IL-1 Ra) naturally occurring anti-inflammatory interleukin-1 family pro-inflammatory cytokines. Despite its outstanding broad-spectrum effects, IL-1 Ra has short biological half-life (4–6 h). The slow-release performance greatly improved bovine serum albumin nanoparticles (BNP). addition, modified HAMA exhibited good injectability porosity, efficient uniform loading was achieved via bond. microenvironment significantly reversed transporting microspheres-BNPs (Modified MS) degenerative nucleus pulposus.

Language: Английский

Citations

3