International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 139134 - 139134
Published: Dec. 1, 2024
Language: Английский
Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This review discusses the recent developments in copper-based nanomaterials that utilize copper-induced cell death, categorized by materials systems, while highlighting limitations of current cuproptosis related nanomaterials.
Language: Английский
Citations
2
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 244, P. 114163 - 114163
Published: Aug. 14, 2024
Language: Английский
Citations
10
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 24, 2025
Periodontitis is a significant global public health issue associated with the onset and progression of various systemic diseases, thereby requiring additional research clinical attention. Although ferroptosis cuproptosis have emerged as areas in medical field, their precise roles pathogenesis periodontitis remain unclear. We aim to systematically summarize current on periodontal disease investigate glutathione pathway autophagy connecting during periodontitis. Further, we propose that homeostatic imbalance copper iron, driven by pathogens, may contribute elevated oxidative stress, representing potential unifying link between involved This article presents comprehensive overview molecular mechanisms underlying periodontitis, offering novel theoretical insights into its therapeutic targets.
Language: Английский
Citations
1
The Chemical Record, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 2, 2025
Triple-negative breast cancer (TNBC) represents a highly aggressive and prognostically unfavorable subtype of cancer, characterized by the absence common hormone receptors, which renders conventional therapies largely ineffective. This review comprehensively examines molecular clinical characteristics TNBC, underscoring substantial challenges inherent in its treatment innovative potential targeted nanoprobes advancing both diagnostic therapeutic paradigms. Through modification targeting molecules, can deliver agents specific to TNBC cells, thus significantly improving sensitivity modalities efficacy interventions. Our discussion systematically explores application various molecules their advantages limitations. In addition, this presents series multifunctional that are designed perform functions, providing synergistic approach TNBC. These advanced enable precise tumor localization while monitoring response real time, facilitating more personalized dynamic regimen. The major obstacles encountered during translation discussed detail. use leap forward medicine for current research efforts will continue refine these technologies improve applicability.
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 10, 2025
Breast cancer is the most commonly diagnosed worldwide. Metal metabolism pivotal for regulating cell fate and drug sensitivity in breast cancer. Iron copper are essential metal ions critical maintaining cellular function. The accumulation of iron triggers distinct death pathways, known as ferroptosis cuproptosis, respectively. Ferroptosis characterized by iron-dependent lipid peroxidation, while cuproptosis involves copper-induced oxidative stress. They increasingly recognized promising targets development anticancer drugs. Recently, compelling evidence demonstrated that interplay between plays a crucial role progression. This review elucidates converging pathways Moreover, we examined value genes associated with clinical diagnosis treatment cancer, mainly outlining potential co-targeting approach. Lastly, delve into current challenges limitations this strategy. In general, offers an overview interaction offering valuable perspectives further research treatment.
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114165 - 114165
Published: Jan. 27, 2025
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 21, 2025
Abstract Tumor cells exploit abnormal redox homeostasis and the pro‐tumorigenic effect of reactive oxygen species (ROS) to enhance their survival progression. However, excessively high levels ROS can exceed oxidative stress threshold tumor cells, inducing cell death. This occur by selectively elevating concentration H 2 O in through both endogenous exogenous mechanisms. The generated serves as a precursor for toxic ROS, such • OH 1 , via chemodynamic photodynamic therapy, respectively, leading apoptosis, necrosis, ferroptosis. Strategies boost include direct delivery amplifying generation inhibiting antioxidant enzymes, leveraging glucose oxidase, employing photocatalytic therapy (PCT), utilizing metal peroxides. Among them, peroxides have displayed remarkable performance due excellent potential elevate within while simultaneously normalizing acidic hypoxic conditions microenvironment (TME). Moreover, these nanostructures sensitivity complementary treatments, like chemotherapy. review summarizes advanced perspectives design, synthesis, comparative analysis ‐generating nanoplatforms, emphasizing capacity treat various cancers.
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 23, 2025
Abstract Tumor recurrence and wound infection present significant challenges to patient recovery following surgery, underscoring the need for effective therapeutic strategies improve prognosis by mitigating these complications. This study introduces novel synthesis methods honeycomb‐like CuMnOx nanozymes CuO 2 nanoflowers with multienzymatic activity pH‐responsive properties. The enzymatic activities of can be regulated pH changes in tumor or microenvironments, while overcome limitation insufficient endogenous H O release ROS weakly acidic conditions. To realize their synergistic effects, nanozymes, along photothermal agent IR820, are co‐assembled into low‐melting point agarose solution, forming a thermosensitive nanozyme‐based hydrogel (CuMnOx@CuO @IR820 hydrogel, CMCI Gel), which facilitates controlled drug delivery exerts enhanced efficiency under low‐temperature therapy (LTPTT, <48 °C). In vitro vivo studies demonstrated that Gel effectively ablated cells range bacteria, including drug‐resistant bacteria like MRSA . Furthermore, it reduces inflammation, promotes vascular regeneration collagen deposition, accelerates healing. injectability thermosensitivity allow localized treatment, minimizing systemic side effects. Overall, benefits highlight as promising adjunctive prevent postsurgery infection.
Language: Английский
Citations
0
Cancer Management and Research, Journal Year: 2025, Volume and Issue: Volume 17, P. 625 - 637
Published: March 1, 2025
Triple-negative breast cancer (TNBC) is characterized by aggressive behavior, high metastatic potential, and frequent relapses, presenting significant treatment challenges. Ferroptosis, a unique form of programmed cell death marked iron-dependent lipid peroxidation, has emerged as crucial factor in biology. Recent studies indicate that TNBC cells possess distinct metabolic profile linked to iron glutathione, which may render them more susceptible ferroptosis than other subtypes. Moreover, plays role the interactions between immune tumor cells, suggesting its potential modulate microenvironment influence response against TNBC.Evidence reveals not only affects viability but also alters promoting release damage-associated molecular patterns (DAMPs), can recruit site. Specific ferroptosis-related genes biomarkers, such ACSL4 GPX4, demonstrate altered expression tissues, offering promising avenues for diagnostic prognostic applications. Furthermore, preclinical models, induction been shown enhance efficacy existing therapies, indicating synergistic effect could be harnessed therapeutic benefit. The compelling link underscores novel target. Future research should focus on developing strategies exploit conjunction with traditional including identification natural compounds efficacious inducers personalized regimens. This review elucidates multifaceted implications TNBC, providing valuable insights improving both diagnosis this formidable subtype.
Language: Английский
Citations
0
Cancer Drug Resistance, Journal Year: 2025, Volume and Issue: unknown
Published: March 26, 2025
Cancer cells often develop tolerance to chemotherapy, targeted therapy, and immunotherapy drugs either before or during treatment. The significant heterogeneity among various tumors poses a critical challenge in modern cancer research, particularly overcoming drug resistance. Copper, as an essential trace element the body, participates biological processes of diseases, including cancers. growth many types tumor exhibits heightened dependence on copper. Thus, targeting copper metabolism inducing cuproptosis may be potential ways overcome Copper chelators have shown resistance by copper-dependent cells. In contrast, ionophores, copper-based nanomaterials, other small molecules been used induce cell death (cuproptosis) cells, drug-resistant This review summarizes regulation role resistance, providing ideas for future.
Language: Английский
Citations
0