Multifunctional Hydrogel Microneedles (HMNs) in Drug Delivery and Diagnostics

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 206 - 206

Published: March 15, 2025

Hydrogel microneedles (HMNs) have emerged as a transformative platform for minimally invasive drug delivery and biosensing, offering enhanced bioavailability, controlled release, real-time biomarker detection. By leveraging swelling hydrogels, nanomaterial integration, stimuli-responsive properties, HMNs provide precision medicine capabilities across diverse therapeutic diagnostic applications. However, challenges remain in mechanical stability, hydrogel-based MNs must balance flexibility with sufficient strength skin penetration. Drug retention release require optimization to prevent premature diffusion ensure sustained effects. Additionally, biosensing accuracy is influenced by variability interstitial fluid extraction signal transduction. Clinical translation hindered regulatory hurdles, scalability concerns, the need extensive safety validation human trials. This review critically examines key materials, fabrication techniques, functional testing frameworks of while addressing these limitations. Furthermore, we explore future research directions smart wearable MNs, AI-assisted hybrid drug–device platforms optimize transdermal medicine. Overcoming barriers will drive clinical adoption HMNs, paving way next-generation patient-centered therapeutics diagnostics.

Language: Английский

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Smart Microneedles in Biomedical Engineering: Harnessing Stimuli‐Responsive Polymers for Novel Applications

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(12)

Published: Dec. 1, 2024

ABSTRACT This review aims to provide a comprehensive analysis of recent advancements in smart microneedles (MNs) within the biomedical field, focusing on integration stimuli‐responsive polymers for enhanced therapeutic and diagnostic applications. Conventional drug delivery methods are known face limitations precision, safety, patient compliance, which can be addressed by innovative features MNs. Through use various polymers, these MNs have been designed react environmental or physiological cues, allowing on‐demand release, biomarker sensing, localized interventions. Fundamental materials used fabrication MNs, including metals, composite hydrogels, reviewed, different categories stimuli‐responsiveness, such as photo, electro, thermal, mechanical, biochemical, explored. Application‐specific designs areas delivery, cancer therapy, diabetes management, skin disease treatments also examined. this discussion, it is highlighted that poised play significant role advancing personalized noninvasive medical treatments.

Language: Английский

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Nanocomposites in focus: tailoring drug delivery for enhanced therapeutic outcomes

Future Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 28, 2025

Abstract Background Nanocomposites made of nanoscale materials may be employed to create innovative drug delivery systems that interface better with biological membranes and selectively deliver drugs specific cells for targeted personalized treatment. Due its versatility usage in construction, marine, car, aerospace, defense, disciplines, nanocomposites research is expanding. Many researchers are introducing nanoparticles the matrix improve their qualities. Main body abstract As categorized into polymeric, metallic, ceramic nanocomposites, performance characteristics improved by different sophisticated top-down bottom-up preparation methods including situ polymerization, intercalation techniques, sol–gel, hydrothermal. These can used applications such as controlled release, within cells, pH-responsive which take advantage tumor microenvironments. They efficacy cancer therapy modulating immune system through an checkpoint blockade, PD-1/PD-L1. The composition polymeric metallic formulations incorporating them briefed this work, along justification preference over other conventional composite materials. Characterization techniques study X-ray diffraction, scanning electron microscope, transmission Fourier-transform infrared spectroscopy, thermogravimetry, differential calorimetric summarized depth. Short conclusion described work a comprehensive review on nanocomposite-based system, importance, manufacturing formulation development, characterization, molecular targets. several opportunities explored, limitations prevalent area, future perspectives discussed bring revolution field biomedical applications. figure explains fabrication biopolymer polysaccharides, proteins, polynucleotides carbon nanomaterials, mineral nanoparticles, metal nanostructures. Examples include delivery, flexible sensors monitors, energy sources, lightweight load-bearing structures, focusing processable, realizable, sustainable (created BioRender). Graphical

Language: Английский

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Transdermal Delivery of Timolol Maleate Using Hydrogel Microneedles for the Treatment of Infantile Haemangiomas

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101752 - 101752

Published: April 1, 2025

Language: Английский

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Tough and waterproof microneedles overcome mucosal immunotolerance by modulating antigen release patterns

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 382, P. 113740 - 113740

Published: April 16, 2025

Language: Английский

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Enhancing melanoma therapy with hydrogel microneedles

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 17, 2025

Melanoma is highly invasive and resistant to conventional treatments, accounting for nearly 75% of skin cancer-related deaths globally. Traditional therapies, such as chemotherapy immunotherapy, often exhibit limited efficacy are associated with significant side effects due systemic drug exposure. Microneedles (MNs), an emerging delivery system, offer multiple advantages, including safety, painlessness, minimal invasiveness, controlled release. Among these, hydrogel microneedles (HMNs) stand out their extracellular matrix-like structure swelling-induced continuous channels, which enable the direct therapeutic agents into tumor microenvironment (TME). This approach enhances bioavailability while reducing toxicity, establishing HMNs a promising platform melanoma treatment. review highlights recent advancements in therapy, focusing on applications biomarker extraction early diagnosis role supporting multimodal treatment strategies, chemotherapy, phototherapy, targeted combination therapy. Furthermore, current matrix materials fabrication techniques discussed. Finally, limitations critically analyzed, recommendations future research development provided.

Language: Английский

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A dissolvable microneedle platform for the delivery of tumor-derived total RNA nanovaccines for enhanced tumor immunotherapy

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Microneedle delivery systems for vaccines and immunotherapy

Smart Molecules, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract Microneedles (MNs) offer a precise and minimally invasive platform for delivering vaccines therapeutic agents directly into the skin, leveraging abundance of tissue‐resident immune cells to elicit robust durable responses. Compared traditional intramuscular or subcutaneous vaccination methods, MN‐based demonstrate superior patient compliance, enhanced antigen stability, heightened immunogenicity, positioning them as promising tool in biomedical applications. This review provides comprehensive overview materials fabrication techniques used MN preparation, explores their structural classifications, examines role antigens adjuvants optimizing vaccine efficacy. Furthermore, diverse applications delivery systems preventing infectious diseases, advancing tumor immunotherapy, addressing other immune‐related conditions are discussed.

Language: Английский

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