Bioactive hydrogel formulations for regeneration of pathological bone defects
Journal of Controlled Release,
Journal Year:
2025,
Volume and Issue:
380, P. 686 - 714
Published: Feb. 17, 2025
Language: Английский
pH triggered on-demand tannic acid release via "open-close" of soybean isolate proteins spatial structure for shrimp preservation
Leping Li,
No information about this author
Zhihang Xu,
No information about this author
Huijie Yang
No information about this author
et al.
Food Control,
Journal Year:
2024,
Volume and Issue:
unknown, P. 111034 - 111034
Published: Nov. 1, 2024
Language: Английский
Inflammatory Microenvironment-Modulated Conductive Hydrogel Promotes Vascularized Bone Regeneration in Infected Bone Defects
ACS Biomaterials Science & Engineering,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 12, 2025
Infected
bone
defects
show
a
significant
reduction
in
neovascularization
during
the
healing
process,
primarily
due
to
persistent
bacterial
infection
and
immune
microenvironmental
disorders.
Existing
treatments
are
difficult
simultaneously
meet
requirements
of
antibacterial
anti-inflammatory
for
infected
defects,
which
is
key
clinical
therapeutic
challenge
that
needs
be
addressed.
In
this
study,
conductive
hydrogel
based
on
copper
nanoparticles
was
developed
controlling
remodeling
microenvironment.
The
not
only
effectively
eliminates
bacteria
exist
defect
region
but
also
transmits
electrical
signals
restore
disordered
vitro
studies
have
shown
has
excellent
biocompatibility
can
modulate
macrophage
polarization
by
transmitting
reduce
inflammation
promote
neovascularization.
vivo
further
confirmed
scaffold
rapidly
cleared
infections
significantly
induced
formation
vascularized
new
tissue
within
4
weeks.
This
work
provides
simple
innovative
strategy
fabricate
copper-containing
hydrogels
great
potential
application
field
therapeutics
regeneration.
Language: Английский
A promising multi-component, multi-functional, drug-releasing Cu-doped Fe3O4/bioactive glass/chitosan coating, applied on stainless steel substrate for biomedical applications
International Journal of Biological Macromolecules,
Journal Year:
2025,
Volume and Issue:
unknown, P. 143296 - 143296
Published: April 1, 2025
Language: Английский