Targeting cyclin-dependent kinase 1 (CDK1) in cancer: molecular docking and dynamic simulations of potential CDK1 inhibitors

Medical Oncology, Journal Year: 2022, Volume and Issue: 39(9)

Published: June 20, 2022

Language: Английский

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Cyclin-dependent kinases in breast cancer: expression pattern and therapeutic implications

Medical Oncology, Journal Year: 2022, Volume and Issue: 39(6)

Published: April 29, 2022

Language: Английский

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Targeting tumor microenvironment using tumor-infiltrating lymphocytes as therapeutics against tumorigenesis

Immunologic Research, Journal Year: 2023, Volume and Issue: 71(4), P. 588 - 599

Published: April 1, 2023

Language: Английский

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Identification and analysis of dysregulated fatty acid metabolism genes in breast cancer subtypes

Medical Oncology, Journal Year: 2022, Volume and Issue: 39(12)

Published: Oct. 12, 2022

Language: Английский

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Expression patterns and therapeutic implications of CDK4 across multiple carcinomas: a molecular docking and MD simulation study

Medical Oncology, Journal Year: 2022, Volume and Issue: 39(10)

Published: July 23, 2022

Language: Английский

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Mechanistic elucidation of Juglanthraquinone C targeting breast Cancer: A network Pharmacology-based investigation

Saudi Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 30(7), P. 103705 - 103705

Published: June 15, 2023

Breast cancer is the leading cause of death among women worldwide. Despite recent treatment options like surgery, chemotherapy etc. lethality breast alarming. Natural compounds are considered a better option against carcinoma because their lower side effects and specificity in targeting important proteins involved aberrant activation pathways cancer. A recently discovered compound called Juglanthraquinone C, which found bark Juglans mandshurica Maxim (Juglandaceae) tree has shown promising cytotoxicity hepatocellular carcinoma. However, not much data available on molecular mechanisms followed by this compound. Therefore, we aimed to investigate mechanism C We used network pharmacology technique analyse action validated our study applying various computational tools such as UALCAN, cBioportal, TIMER, docking simulation. The results showed target shared 31 common targets. Moreover, observed that targets multiple deregulated genes TP53, TGIF1, IGF1R, SMAD3, JUN, CDC42, HBEGF, FOS signaling PI3K-Akt pathway, TGF-β MAPK pathway HIPPO pathway. examination revealed investigated drug had high affinity for primary TGIF1 protein. stable protein-ligand combination was generated best hit molecule, according dynamics modeling. main aim examine C's significance prospective understand substance uses since there need discover new therapeutics decrease load current also currently ineffective due several development resistance.

Language: Английский

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Adapalene inhibits the growth of triple-negative breast cancer cells by S-phase arrest and potentiates the antitumor efficacy of GDC-0941

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 8, 2022

Although advances in diagnostics and therapeutics have prolonged the survival of triple-negative breast cancer (TNBC) patients, metastasis, therapeutic resistance, lack targeted therapies remain foremost hurdle effective management TNBC. Thus, evaluation new agents their efficacy combination therapy is urgently needed. The third-generation retinoid adapalene (ADA) has potent antitumor activity, using ADA with existing regimens may improve effectiveness minimize toxicities drug resistance. current study aimed to assess anticancer as a regimen PI3K inhibitor (GDC-0941) TNBC vitro models. Chou-Talalay's method evaluated pharmacodynamic interactions (synergism, antagonism, or additivity) binary combinations. Flow cytometry, Western blotting, silico studies were used analyze mechanism GDC-ADA synergistic cells. GDC demonstrated effect inhibiting proliferation, migration, colony formation tumor Accumulation reactive oxygen species upon co-treatment promoted apoptosis enhanced sensitivity findings indicate that promising agent treating advanced BC tumors enhance growth models while reducing

Language: Английский

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Survivin in Breast Cancer: A Review

Genetic Testing and Molecular Biomarkers, Journal Year: 2022, Volume and Issue: 26(9), P. 411 - 421

Published: Sept. 1, 2022

Breast cancer is the most frequently diagnosed in women and ranks second among causes for cancer-related death women. Gene technology has led to recognition that breast a heterogeneous disease composed of different biological subtypes, genetic profiling enables response chemotherapy be predicted. This fact emphasizes importance selecting sensitive diagnostic prognostic markers early stage more efficient targeted treatments this disease. One such marker appears survivin. Many studies have shown survivin strongly expressed types cancers. Its overexpression been demonstrated cancer, high activity gene associated with poor prognosis worse survival rates.

Language: Английский

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Function and Application of Flavonoids in the Breast Cancer

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(14), P. 7732 - 7732

Published: July 13, 2022

Breast cancer is one of the top causes death, particularly among women, and it affects many women. Cancer can also be caused by various factors, including acquiring genetic alteration. Doctors use radiation to detect treat breast cancer. As a result, becomes radiation-resistant, necessitating new strategy for its treatment. The approach discovered researchers flavonoid, which being researched see if might help radiation-resistant more safely than an approved medicine already used in field. this study focuses on role flavonoids suppression, gene anomalies, resulting apoptotic mechanism.

Language: Английский

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Phyto-therapeutics as anti-cancer agents in breast cancer: Pathway targeting and mechanistic elucidation

Saudi Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 31(3), P. 103935 - 103935

Published: Jan. 21, 2024

Cancer of the breast is mainly prevalent class cancer in females diagnosed over globe. It also happens to be 2nd most reason cancer-related deaths among worldwide. Some common type's therapies for carcinoma involve radiation therapy, chemotherapy, and resection. Many studies are being conducted develop new therapeutic strategies better diagnosis cancer. An enormous number anticancer medications have been developed as a result growing understanding molecular pathways behind advancement Over past few decades, general survival rate has not greatly increased due usage chemically manufactured medications. Therefore, order increase effectiveness current treatments, tactics cutting-edge chemoprevention drugs required. Phytochemicals, which naturally occurring molecules derived from plants, important sources both therapy innovative medication development. These phytochemicals frequently work by controlling linked development spread Increasing antioxidant status, inactivating carcinogens, preventing proliferation, causing cell cycle arrest apoptosis, immune system control some specific ways. This primary objective this review provide an overview active ingredients found natural goods, including information on their pharmacologic action, targets, state knowledge. We given thorough description substances that specifically target study. We've great deal study compounds may help us identify novel targets detection carcinoma.

Language: Английский

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