Medical Oncology, Journal Year: 2022, Volume and Issue: 39(12)
Published: Sept. 30, 2022
Language: Английский
Saudi Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 31(1), P. 103896 - 103896
Published: Dec. 10, 2023
Breast cancer (BC) is the most common type of malignancy globally and main reason why women die from tumours. The Warburg effect, a characteristic tumor, describes how solid tumour cells acclimatize to their diverse surroundings by relying heavily on aerobic glycolysis for production energy. In addition producing key metabolic intermediates that are crucial macromolecules, which enable cell division, invasiveness, drug resistance, transformed energy metabolism also supplies tumor with ATP cellular Here, we evaluated expression profile, prognostic significance, clinical relevance glucose-related genes in BC using bioinformatic approach. To clarify significance development breast tumours, performed functional enrichment investigation deregulated STRING KEGG portal. study depicted 61 examined, 8 had fold change
Language: Английский
Citations
6
Saudi Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 31(2), P. 103916 - 103916
Published: Dec. 23, 2023
B-cell lymphoma/leukemia gene-2 (Bcl-2) is the primary proto-oncogene that has been shown to work by preventing apoptosis/programmed cell death. Bcl-2 combines a variety of cell-generated signals associated survival and death cells. In glioma, lung, breast cancer, over-expression linked an increase in invasion migration. Many treatment regimens target Bcl2 have established approved, thus increasing rates patients. The goal this research was recognize new therapeutic compounds assess expression pattern BC We used various bioinformatic tools as well several vitro assays look out inhibition BC. Our study depicted had strong connection with tumour stroma, notably suppressor cells originating from myeloid tissues. Moreover, silico identified Paclitaxel promising natural substance targets Bcl2. Overall, shows overexpression accelerates development BC, targeting combination other drugs will dramatically improve patient's response prevent emergence drug resistance.
Language: Английский
Citations
6
Elsevier eBooks, Journal Year: 2022, Volume and Issue: unknown, P. 31 - 58
Published: Jan. 1, 2022
Language: Английский
Citations
8
Results in Chemistry, Journal Year: 2024, Volume and Issue: 10, P. 101694 - 101694
Published: July 31, 2024
It is predicted that over 29 million individuals will receive a cancer diagnosis in 2040, making one of the major causes death globally. One biggest obstacles to being overcome treatment drug resistance, which mostly blame for this high rate. Research has therefore concentrated on developing new therapeutic tools, particularly those enable individualized care based features patient. Although ensuring quality life patients been concern scientific community, attempts have made find alternatives creation pharmaceuticals since researchers are aware rising expenses associated with therapy. The trend towards repurposing growing as strategy accelerate development, utilizing proven safety and effectiveness existing approved drugs. central theme review centered exploring potential repurposed medications treating cancer. revolves around Adapalene, traditionally known its acne benefits, now evaluated latest details candidate, potential, Pharmacokinetic Profile, molecular interactions behind anti-tumor efficacy also included paper. In addition, medication combinations covered here useful tactic get restrictions repurposing. concludes represents most promising approaches incorporating combination therapy can address challenges encountered field. Regarding repurposing, Adapalene demonstrated significant various types cancer, including skin colon breast
Language: Английский
Citations
1
Medical Oncology, Journal Year: 2022, Volume and Issue: 39(12)
Published: Sept. 30, 2022
Language: Английский
Citations
6