Chronic alcohol induces subcircuit-specific striatonigral plasticity enhancing the sensorimotor basal ganglia role in action execution DOI Creative Commons
Giacomo Sitzia, Sebastiano Bariselli, Alexa L. Gracias

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(26)

Published: June 28, 2024

Functional deficits in basal ganglia (BG) circuits contribute to cognitive and motor dysfunctions alcohol use disorder. Chronic exposure alters synaptic function neuronal excitability the dorsal striatum, but it remains unclear how affects BG output that is mediated by substantia nigra pars reticulata (SNr). Here, we describe a subpopulation-specific organization of striatal subthalamic (STN) inputs medial lateral SNr. (CIE) potentiated dorsolateral striatum (DLS) did not change dorsomedial STN Chemogenetic inhibition DLS direct pathway neurons revealed an enhanced role for execution instrumental lever-pressing task. Overall, reveal subregion-specific onto SNr find DLS-SNr are accompanied altered control action following CIE.

Language: Английский

Neurosteroid [3α,5α]-3-Hydroxy-pregnan-20-one Enhances the CX3CL1-CX3CR1 Pathway in the Brain of Alcohol-Preferring Rats with Sex-Specificity DOI Creative Commons
Irina Balan, Adelina Grusca, Samantha Lucenell Chéry

et al.

Life, Journal Year: 2024, Volume and Issue: 14(7), P. 860 - 860

Published: July 9, 2024

This study investigates the impact of allopregnanolone ([3α,5α]3-hydroxypregnan-20-one or 3α,5α-tetrahydroprogesterone (3α,5α-THP); 10 mg/kg, IP) on fractalkine/CX3-C motif chemokine ligand 1 (CX3CL1) levels, associated signaling components, and markers for microglial astrocytic cells in nucleus accumbens (NAc) male female alcohol-preferring (P) rats. Previous research suggested that 3α,5α-THP enhances anti-inflammatory interleukin-10 (IL-10) cytokine production brains P rats, with no similar effect observed females. reveals elevates CX3CL1 levels by 16% NAc significant changes males. The increase induced was females across multiple brain regions, including NAc, amygdala, hypothalamus, midbrain, while noted Additionally, rats treated exhibited notable increases receptor (CX3CR1; 48%) transforming growth factor-beta (TGF-β1; 24%) along heightened activation (phosphorylation) signal transducer activator transcription (STAT1; 85%) NAc. Conversely, alterations were Furthermore, decreased glial fibrillary acidic protein (GFAP) 19% both rat without affecting ionized calcium-binding adaptor molecule (IBA1) transmembrane 119 (TMEM119). These findings indicate CX3CL1/CX3CR1 pathway but not males, primarily influencing astrocyte reactivity, activation.

Language: Английский

Citations

1
Differences in Brain Network Topology Based on Alcohol Use History in Adolescents DOI Open Access
Haley Kirse, Mohsen Bahrami, Robert G. Lyday

et al.

Published: Sept. 25, 2023

Approximately 6 million youth aged 12 to 20 consume alcohol monthly in the United States. The effect of consumption adolescence on behavior and cognition is heavily researched, however, little known about how may alter brain function, leading long-term developmental detriments. In order investigate differences connectivity associated with use adolescents, networks were constructed using resting state functional magnetic resonance imaging data collected by National Consortium Alcohol NeuroDevelopment Adolescence (NCANDA) from 698 (12-21 years, 117 hazardous drinkers 581 no/low drinkers). Analyses assessed network topology based eight pre-defined networks, as well whole-brain connectivity. Within central executive (CEN), basal ganglia (BGN), sensorimotor (SMN), demonstrated stronger more frequent connections between highly globally efficient nodes, fewer weaker clustered nodes. Inverse results observed within dorsal attention (DAN), visual (VN), frontotemporal (FTN), demonstrating nodes high efficiency increased frequency compared drinkers. Results this study show clear organizational adolescents or use, suggesting that aberrant these risky drinking behaviors.

Language: Английский

Citations

1
Chronic alcohol induces subcircuit-specific striatonigral plasticity shifting action control to the sensorimotor striatum DOI Open Access
Giacomo Sitzia, Sebastiano Bariselli, Alexa L. Gracias

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 15, 2023

Abstract While cortico-striatal circuit deficits contribute to Alcohol Use Disorder, the impact of alcohol on synaptic function in basal ganglia output, substantia nigra pars reticulata (SNr), remains unclear. Here, we found that inputs from dorsomedial (DMS) and dorsolateral striatum (DLS) differ their presynaptic properties target molecularly distinct subpopulations SNr neurons. We also discovered indirect pathway subthalamic (STN) medial lateral have different STN are stronger SNr. Chronic exposure (CIE) potentiated DLS but did not affect strength release DMS Chemogenetic inhibition direct projection neurons impaired action performance an operant conditioning task CIE mice control mice. Overall, our work identifies a mechanism whereby chronic induces gain for striatum. Teaser selectively potentiates SNr, enhancing role control.

Language: Английский

Citations

1
Differences in Brain Network Topology Based on Alcohol Use History in Adolescents DOI Creative Commons
Haley Kirse, Mohsen Bahrami, Robert G. Lyday

et al.

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(12), P. 1676 - 1676

Published: Dec. 5, 2023

Approximately 6 million youth aged 12 to 20 consume alcohol monthly in the United States. The effect of consumption adolescence on behavior and cognition is heavily researched; however, little known about how may alter brain function, leading long-term developmental detriments. In order investigate differences connectivity associated with use adolescents, networks were constructed using resting-state functional magnetic resonance imaging data collected by National Consortium Alcohol NeuroDevelopment Adolescence (NCANDA) from 698 (12–21 years; 117 hazardous drinkers 581 no/low drinkers). Analyses assessed network topology based eight predefined networks, as well whole-brain connectivity. Within central executive (CEN), basal ganglia (BGN), sensorimotor (SMN), demonstrated stronger more frequent connections between highly globally efficient nodes, fewer weaker clustered nodes. Inverse results observed within dorsal attention (DAN), visual (VN), frontotemporal (FTN), demonstrating nodes high efficiency increased frequency compared drinkers. Cross-sectional this study show clear organizational adolescents or use, suggesting that aberrant these risky drinking behaviors.

Language: Английский

Citations

1
Chronic alcohol induces subcircuit-specific striatonigral plasticity enhancing the sensorimotor basal ganglia role in action execution DOI Creative Commons
Giacomo Sitzia, Sebastiano Bariselli, Alexa L. Gracias

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(26)

Published: June 28, 2024

Functional deficits in basal ganglia (BG) circuits contribute to cognitive and motor dysfunctions alcohol use disorder. Chronic exposure alters synaptic function neuronal excitability the dorsal striatum, but it remains unclear how affects BG output that is mediated by substantia nigra pars reticulata (SNr). Here, we describe a subpopulation-specific organization of striatal subthalamic (STN) inputs medial lateral SNr. (CIE) potentiated dorsolateral striatum (DLS) did not change dorsomedial STN Chemogenetic inhibition DLS direct pathway neurons revealed an enhanced role for execution instrumental lever-pressing task. Overall, reveal subregion-specific onto SNr find DLS-SNr are accompanied altered control action following CIE.

Language: Английский

Citations

0