Addiction Neuroscience, Journal Year: 2023, Volume and Issue: 9, P. 100136 - 100136
Published: Nov. 10, 2023
Language: Английский
Microchemical Journal, Journal Year: 2024, Volume and Issue: 203, P. 110859 - 110859
Published: May 27, 2024
Electronic cigarettes (e-cigarettes) have become popular worldwide with the market growing exponentially in some countries. The absence of product standards and safety regulations requires urgent development analytical methodologies for holistic control diversity such products. An approach based on low-field nuclear magnetic resonance (LF-NMR) at 80 MHz is presented simultaneous determination key parameters: carrier solvents (vegetable glycerine (VG), propylene glycol (PG) water), total nicotine as well free-base fraction. Moreover, qualitative quantitative fourteen weak organic acids deliberately added to enhance sensory characteristics e-cigarettes was possible. In most cases these parameters can be rapidly conveniently determined without using any sample manipulation dilution, extraction or derivatization steps. method applied 37 authentic samples. particular, eight different content up 56 mg/mL were detected. Due its simplicity, used routine regulatory study release behaviour other constituents
Language: Английский
Citations
3
Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117885 - 117885
Published: Feb. 1, 2025
Indoor vaping can lead to third-hand vapour exposure, evidenced by the presence of nicotine and carcinogenic nitrosamines on indoor surfaces. Children are at high risk such exposure. This study aimed investigate effects exposure cognitive function in young mice. Male mice (Balb/c, 4 weeks) were exposed cotton towels treated with e-cigarette without (9 L chamber filled 20 puffs for 2 hours) changed daily four weeks. Vapour was generated from tobacco-flavoured liquids (50 % propylene glycol, 50 vegetable glycerine, 18 mg or 0 nicotine) using a human device. Mice nicotine-free showed impaired short-term memory, while those nicotine-containing exhibited significantly increased anxiety-like behaviours. Both groups had reduced neuron numbers cortex microglia pro-inflammatory cytokine expression brain. Third-hand impair memory increase anxiety, some being nicotine-independent. These findings highlight potential risks vaping, especially environments frequented younger people, including children adolescents, need further research identify underlying mechanisms. SYNOPSIS: is first highlighting impairment due residues mouse model.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: March 19, 2024
Abstract Nicotine use is a leading cause of preventable deaths worldwide, and most those who attempt to quit will relapse. While electronic cigarettes other nicotine delivery systems (ENDS) were presented as safer alternative traditional promoted devices help tobacco smokers reduce or smoking, they have instead contributed increasing among youths. Despite this, ENDS also represent useful tool create novel preclinical animal models exposure that more accurately human use. In this study, we validated chronic, intermittent, ENDS-based passive vapor model in mice, then measured changes multiple behaviors related abstinence. First, performed behavioral dose curve investigate the effects different inter-vape intervals on various measures including body weight, locomotor activity, pain hypersensitivity. Next, pharmacokinetic study measure plasma levels cotinine following chronic for each interval. Finally, utilized behavior test battery at single dosing regimen produces blood equivalent order characterize nicotine, vehicle, airflow identified nicotine-induced impairments cognitive behavior.
Language: Английский
Citations
1
Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17
Published: Nov. 16, 2023
Since their introduction in the United States and Europe 2007, electronic cigarettes (E-Cigs) have become increasingly popular among smokers. Nicotine, a key component both tobacco e-cigarettes, can exist two forms: nicotine-freebase (FBN) nicotine salts (NS). While salt is becoming more effect of on reinforcement-related behaviors remains poorly understood. This study aimed to compare reinforcing effects animal models drug self-administration explore potential mechanisms that may contribute these differences. The results demonstrated three (nicotine benzoate, lactate, tartrate) resulted greater rats compared nicotine-freebase. Moreover, withdrawal-induced anxiety symptoms were lower groups than group. suggested differences pharmacokinetics vivo explain observed behavioral Overall, this provides valuable insights into as well between salts.
Language: Английский
Citations
3
Nicotine & Tobacco Research, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 16, 2024
Abstract Introduction The increasing prevalence of electronic nicotine delivery systems and alcohol drinking has led to increases in co-use. However, the impact ENDs on brain activity binge behavior is not fully understood. Aims Methods We subjected female male C57BL/6J mice a voluntary vapor exposure paradigm. first established baseline using drinking-in-the-dark In third week, were exposed 3 hours sessions prior ethanol access, water levels measured. Following last session we measured blood (BAL) collected tissue measure by cFos expression. Results Nicotine decreased both intake males, only reduced females, did alter either sex. increased central amygdala females but had no effect males. ventral tegmental area (VTA) produce any additional increases. alcohol-exposed males significantly lower BAL as compared suggesting sex differences patterns where appeared “front-load” drank more throughout end session. Conclusions These results highlight important co-exposure underscore importance further investigating neurobiological effects metabolism females. Implications With use, it imperative understand behavioral consequences co-use with focus differences. Using passive inhalation paradigm, investigated mice. found from this poly-substance use approach. change drinking. Alcohol produced sex-specific VTA activity.
Language: Английский
Citations
0
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 2, 2024
Abstract Nicotine use is a leading cause of preventable deaths worldwide, and most those who attempt to quit will relapse. While electronic cigarettes other nicotine delivery systems (ENDS) were presented as safer alternative traditional promoted devices help tobacco smokers reduce or smoking, they have instead contributed increasing among youths. Despite this, ENDS also represent useful tool create novel preclinical animal models exposure that more accurately human use. In this study, we validated chronic, intermittent, ENDS-based passive vapor model in mice, then measured changes multiple behaviors related abstinence. First, performed behavioral dose curve investigate the effects different inter-vape intervals on various measures including body weight, locomotor activity, pain hypersensitivity. Next, pharmacokinetic study measure plasma levels cotinine following chronic for each interval. Finally, utilized behavior test battery at single dosing regimen produces blood equivalent order characterize nicotine, vehicle, airflow identified nicotine-induced impairments cognitive behavior.
Language: Английский
Citations
0
Addiction Neuroscience, Journal Year: 2023, Volume and Issue: 9, P. 100136 - 100136
Published: Nov. 10, 2023
Language: Английский
Citations
0