Theranostics,
Journal Year:
2021,
Volume and Issue:
11(12), P. 5911 - 5925
Published: Jan. 1, 2021
Poor
healing
response
after
rotator
cuff
reconstruction
is
multifactorial,
with
the
inflammatory
microenvironment
and
deficiency
of
stem
cell
differentiation
factors
at
lesion
site
being
most
relevant.
However,
there
a
lack
effective
tissue
engineering
strategies
that
can
simultaneously
exert
anti-inflammatory
pro-differentiation
effects
to
promote
healing.
Methods:
In
this
study,
we
synthesized
characterized
novel
active
drug
delivery
vector
successfully
overcame
challenge
simultaneous
high-efficiency
loading
controlled
release
Mg2+
curcumin.
The
composite
hydrogel
were
evaluated
in
vitro
vivo.
Moreover,
tendon-to-bone
interface
was
studied
by
histology,
immunofluorescence,
biomechanical
tests.
Results:
exhibited
excellent
biocompatibility
injectability,
good
adhesiveness,
rapid
self-healing.
released
curcumin
showed
obvious
antioxidation
effects,
which
protected
cells
tendon
matrix.
Furthermore,
promoted
aggregation
chondrogenesis.
tests
histological
results
rat
tear
model
8
weeks
surgery
indicated
significantly
enhanced
Conclusions:
mediated
sustained
situ
effectively
via
effects.
Therefore,
offers
significant
promise
for
repair.
Chemical Reviews,
Journal Year:
2017,
Volume and Issue:
117(5), P. 4376 - 4421
Published: Feb. 21, 2017
Although
the
biological
functions
of
cell
and
tissue
can
be
regulated
by
biochemical
factors
(e.g.,
growth
factors,
hormones),
biophysical
effects
materials
on
regulation
activity
are
receiving
more
attention.
In
this
Review,
we
systematically
summarize
recent
progress
how
biomaterials
with
controllable
properties
compositional/degradable
dynamics,
mechanical
properties,
2D
topography,
3D
geometry)
regulate
behaviors
adhesion,
spreading,
proliferation,
alignment,
differentiation
or
self-maintenance
stem
cells)
tissue/organ
functions.
How
features
influence
regeneration
have
been
elucidated.
Current
challenges
a
perspective
development
novel
that
modulate
specific
discussed.
The
interdependent
relationship
between
biology
leads
us
to
propose
concept
"materiobiology",
which
is
scientific
discipline
studies
at
cell,
tissue,
organ,
whole
organism
levels.
This
Review
highlights
it
important
develop
ECM-mimicking
having
self-regenerative
capacity
stimulate
regeneration,
instead
attempting
recreate
complexity
living
tissues
constructs
ex
vivo.
principles
materiobiology
may
benefit
providing
combinative
bioactive
cues
activate
migration
cells
from
endogenous
reservoirs
(i.e.,
niches),
robust
scalable
self-healing
mechanisms,
unlock
body's
innate
powers
regeneration.
Nature Communications,
Journal Year:
2019,
Volume and Issue:
10(1)
Published: Oct. 11, 2019
Abstract
Implanted
scaffolds
with
inductive
niches
can
facilitate
the
recruitment
and
differentiation
of
host
cells,
thereby
enhancing
endogenous
tissue
regeneration.
Extracellular
matrix
(ECM)
derived
from
cultured
cells
or
natural
tissues
exhibit
superior
biocompatibility
trigger
favourable
immune
responses.
However,
lack
hierarchical
porous
structure
fails
to
provide
guidance
cues
for
directional
migration
spatial
organization,
consequently
limit
morpho-functional
integration
oriented
tissues.
Here,
we
engineer
ECM
parallel
microchannels
(ECM-C)
by
subcutaneous
implantation
sacrificial
templates,
followed
template
removal
decellularization.
The
advantages
such
ECM-C
are
evidenced
close
regulation
in
vitro
cell
activities,
enhanced
infiltration
vascularization
upon
vivo
implantation.
We
demonstrate
versatility
flexibility
these
regenerating
vascularized
innervated
neo-muscle,
neo-nerve
pulsatile
neo-artery
functional
integration.
This
strategy
has
potential
yield
inducible
biomaterials
applications
across
engineering
regenerative
medicine.
Pharmaceutics,
Journal Year:
2019,
Volume and Issue:
11(4), P. 182 - 182
Published: April 15, 2019
Electrospinning
technologies
have
been
applied
in
the
field
of
tissue
engineering
as
materials,
with
nanoscale-structures
and
high
porosity,
can
be
easily
prepared
via
this
method
to
bio-mimic
natural
extracellular
matrix
(ECM).
Tissue
aims
fabricate
functional
biomaterials
for
repairment
regeneration
defective
tissue.
In
addition
structural
simulation
accelerating
repair
process
achieving
a
high-quality
regeneration,
combination
bioactive
molecules
is
required
an
ideal
tissue-engineering
scaffold.
Due
diversity
materials
selection
electrospinning,
great
flexibility
drug
delivery
systems
achieved.
Various
drugs
including
antibiotic
agents,
vitamins,
peptides,
proteins
incorporated
into
electrospun
scaffolds
using
different
electrospinning
techniques
drug-loading
methods.
This
review
recent
research
on
nanofibrous
applications,
development
preparation
methods,
various
molecules.
These
studies
are
based
fabrication
blood
vessels,
nerve
tissues,
cartilage,
bone
defects,
treatment
aneurysms
skin
wounds,
well
their
applications
related
oral
mucosa
dental
fields.
these
studies,
due
optimal
loading
methods
vitro
vivo
experiments
demonstrated
that
exhibited
desirable
effects
damaged
and,
thus,
excellent
potential
clinical
application.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(1), P. 175 - 209
Published: Jan. 6, 2021
Most
tissues
of
the
human
body
are
characterized
by
highly
anisotropic
physical
properties
and
biological
organization.
Hydrogels
have
been
proposed
as
scaffolding
materials
to
construct
artificial
due
their
water-rich
composition,
biocompatibility,
tunable
properties.
However,
unmodified
hydrogels
typically
composed
randomly
oriented
polymer
networks,
resulting
in
homogeneous
structures
with
isotropic
different
from
those
observed
systems.
Magnetic
potential
agents
provide
anisotropy
required
for
use
on
tissue
engineering.
Moreover,
intrinsic
magnetic
nanoparticles
enable
magnetomechanic
remote
actuators
control
behavior
cells
encapsulated
within
under
application
external
fields.
In
this
review,
we
combine
a
detailed
summary
main
strategies
prepare
showing
controlled
an
analysis
approaches
available
incorporation
into
hydrogels.
The
magnetically
responsive
nanocomposite
engineering
is
also
reviewed.
Materials,
Journal Year:
2020,
Volume and Issue:
13(9), P. 2153 - 2153
Published: May 6, 2020
Pharmaceutical
nano-fibers
have
attracted
widespread
attention
from
researchers
for
reasons
such
as
adaptability
of
the
electro-spinning
process
and
ease
production.
As
a
flexible
method
fabricating
nano-fibers,
is
extensively
used.
An
unit
composed
pump
or
syringe,
high
voltage
current
supplier,
metal
plate
collector
spinneret.
Optimization
attained
undertaken
through
manipulation
variables
formulation,
including
concentration,
viscosity,
molecular
mass,
physical
phenomenon,
well
environmental
parameters
temperature
humidity.
The
achieved
by
can
be
utilized
drug
loading.
mixing
two
more
medicines
performed
via
electro-spinning.
Facilitation
inhibition
burst
release
use
approach.
This
potential
anticipated
to
facilitate
progression
in
applications
modification
tissue
engineering
(TE).
present
review
aims
focus
on
electro-spinning,
optimization
parameters,
pharmacological
applications,
biological
characteristics,
vivo
analyses
electro-spun
nano-fibers.
Furthermore,
developments
upcoming
investigation
directions
are
outlined
advancement
TE.
Moreover,
possible
complications
future
these
summarized
detail.
Advanced Materials,
Journal Year:
2019,
Volume and Issue:
32(18)
Published: Dec. 9, 2019
Engineering
synthetic
scaffolds
to
repair
and
regenerate
ruptured
native
tendon
ligament
(T/L)
tissues
is
a
significant
engineering
challenge
due
the
need
satisfy
both
unique
biological
biomechanical
properties
of
these
tissues.
Long-term
clinical
outcomes
relying
solely
on
high
uniaxial
tensile
strength
are
poor
with
rates
implant
rupture
synovitis.
Ideal
biomaterials
for
T/L
regeneration
possess
appropriate
necessary
successful
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
36, P. 62 - 82
Published: Feb. 28, 2024
Tendon-bone
interface
injuries
pose
a
significant
challenge
in
tissue
regeneration,
necessitating
innovative
approaches.
Hydrogels
with
integrated
supportive
features
and
controlled
release
of
therapeutic
agents
have
emerged
as
promising
candidates
for
the
treatment
such
injuries.
In
this
study,
we
aimed
to
develop
temperature-sensitive
composite
hydrogel
capable
providing
sustained
magnesium
ions
(Mg2+).
We
synthesized
magnesium-Procyanidin
coordinated
metal
polyphenol
nanoparticles
(Mg-PC)
through
self-assembly
process
them
into
two-component
hydrogel.
The
was
composed
dopamine-modified
hyaluronic
acid
(Dop-HA)
F127.
To
ensure
mitigate
"burst
release"
effect
Mg2+,
covalently
crosslinked
Mg-PC
coordination
bonds
catechol
moiety
within
This
crosslinking
strategy
extended
window
Mg2+
concentrations
up
56
days.
resulting
(Mg-PC@Dop-HA/F127)
exhibited
favorable
properties,
including
injectability,
thermosensitivity
shape
adaptability,
making
it
suitable
injection
adaptation
irregularly
shaped
supraspinatus
implantation
sites.
Furthermore,
Procyanidins,
which
attracted
mesenchymal
stem
progenitor
cells,
alleviated
inflammation,
promoted
macrophage
polarization
towards
M2
phenotype.
Additionally,
enhanced
collagen
synthesis
mineralization,
facilitating
repair
tendon-bone
interface.
By
incorporating
multilevel
phenolic
networks
(MPN)
control
ion
release,
these
hybridized
hydrogels
can
be
customized
various
biomedical
applications.
Science Advances,
Journal Year:
2024,
Volume and Issue:
10(10)
Published: March 8, 2024
Limited
motor
activity
due
to
the
loss
of
natural
structure
impedes
recovery
in
patients
suffering
from
tendon-to-bone
injury.
Conventional
biomaterials
focus
on
strengthening
regenerative
ability
tendons/bones
restore
structure.
However,
owing
ignoring
immune
environment
and
lack
multi-tissue
function,
satisfactory
outcomes
remain
elusive.
Here,
combined
manganese
silicate
(MS)
nanoparticles
with
tendon/bone-related
cells,
immunomodulatory
multicellular
scaffolds
were
fabricated
for
integrated
regeneration
tendon-to-bone.
Notably,
by
integrating
biomimetic
cellular
distribution
MS
nanoparticles,
exhibited
diverse
bioactivities.
Moreover,
enhanced
specific
differentiation
via
regulating
macrophages,
which
was
mainly
attributed
secretion
PGE2
macrophages
induced
Mn
ions.
Furthermore,
three
animal
results
indicated
that
achieved
immunomodulation,
regeneration,
function
at
interfaces.
Thus,
based
inorganic
offer
an
innovative
concept
immunomodulation
soft/hard
tissue
