Magnetic-responsive hydrogels: From strategic design to biomedical applications

Journal of Controlled Release, Journal Year: 2021, Volume and Issue: 335, P. 541 - 556

Published: June 11, 2021

Language: Английский

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Interpenetrating polymer network hydrogels for removal of synthetic dyes: A comprehensive review

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 486, P. 215152 - 215152

Published: April 3, 2023

Language: Английский

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Nanomaterial based PVA nanocomposite hydrogels for biomedical sensing: Advances toward designing the ideal flexible/wearable nanoprobes

Advances in Colloid and Interface Science, Journal Year: 2022, Volume and Issue: 305, P. 102705 - 102705

Published: May 18, 2022

Language: Английский

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4D printing of patterned multimaterial magnetic hydrogel actuators

Additive manufacturing, Journal Year: 2021, Volume and Issue: 49, P. 102506 - 102506

Published: Nov. 25, 2021

This paper demonstrates a new class of printable magnetic hydrogels that can be successfully used for multimaterial direct ink printing (4D printing) soft actuators. To date, most reports on actuation have not considered biocompatibility issues associated with materials and synthetic polymers. For this reason, in study, considerable attention was given to developing bionanocomposites exhibit noncytotoxicity hence may biomedical applications. Three inks various concentrations nanoparticles (MNPs) were print 3D objects, such as tubes (wheels), cubes, cantilevers. The interactions between MNPs hydrogel precursor network accounted excellent shear thinning properties the inks. Usually, actuators move or change shape upon anisotropic swelling deswelling, possible only an aqueous environment. Our study addresses challenge by incorporating into hydrogel, allowing contactless in-air control motion. Because high structural integrity we state is method obtaining construct resolution, fidelity, tunable distribution MNPs, induced macroscopic anisotropy. are highly porous noncytotoxic towards fibroblasts but also good mechanical stability unique responsiveness. simple approach allowed us fabricate different patterns, composed non-magnetic materials. results demonstrate interplay nonmagnetic influences performance illustrated magnetically rolling, jumping, bending. It shown programmable patterning leads development macroscopically material. confirmed intersection 4D responsive promises fulfill future robotics' functionality requirements.

Language: Английский

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Recent advances on sustainable adsorbents for the remediation of noxious pollutants from water and wastewater: A critical review

Arabian Journal of Chemistry, Journal Year: 2023, Volume and Issue: 16(12), P. 105303 - 105303

Published: Sept. 26, 2023

This review article evaluates and compares the efficiency of various sustainable adsorbents for removal noxious pollutants from water environments. study discusses types concerning their performance suitability. Adsorbent include natural-based, carbon-based, waste-based, biomass-based, biopolymers-based, nanocomposites-based adsorbents, as well metallic organic frameworks, aerogels, networking crystalline solids, zeolite nanoparticles, dendrimers were reviewed. Characterisation, modification, fabrication, adsorption capacities under different conditions, isotherm models, kinetics also Adsorption pH values, adsorbent doses, concentrations, temperature, size particles have been described. One basic needs in wastewater is formulation optimisation, using columnar operations, more importantly, they can be produced quickly should cost-effective. Various studies reported a broad range values thermodynamic parameters pollutants, suggesting adsorbent's nature an essential factor affecting thermodynamics pollutant sorption. The regeneration reusability potential other discussed, along with molecular modelling, simulation, knowledge gaps, future perspectives

Language: Английский

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Injectable remote magnetic nanofiber/hydrogel multiscale scaffold for functional anisotropic skeletal muscle regeneration

Biomaterials, Journal Year: 2022, Volume and Issue: 285, P. 121537 - 121537

Published: April 25, 2022

Language: Английский

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Mechano‐Activated Cell Therapy for Accelerated Diabetic Wound Healing

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(47)

Published: Sept. 8, 2023

Chronic diabetic wounds are a significant global healthcare challenge. Current strategies, such as biomaterials, cell therapies, and medical devices, however, only target few pathological features have limited efficacy. A powerful platform technology combining magneto-responsive hydrogel, cells, wireless magneto-induced dynamic mechanical stimulation (MDMS) is developed to accelerate wound healing. The hydrogel encapsulates U.S. Food Drug Administration (FDA)-approved fibroblasts keratinocytes achieve ∼3-fold better closure in mouse model. MDMS acts nongenetic mechano-rheostat activate fibroblasts, resulting ∼240% proliferation, ∼220% more collagen deposition, improved keratinocyte paracrine profiles via the Ras/MEK/ERK pathway boost angiogenesis. property also enables on-demand insulin release for spatiotemporal glucose regulation through increasing network deformation interstitial flow. By mining scRNAseq data, mechanosensitive fibroblast subpopulation identified that can be mechanically tuned enhanced proliferation production, maximizing therapeutic impact. "all-in-one" system addresses major factors associated with single platform, potential applications other challenging types.

Language: Английский

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Dynamic Stimulations with Bioengineered Extracellular Matrix‐Mimicking Hydrogels for Mechano Cell Reprogramming and Therapy

Advanced Science, Journal Year: 2023, Volume and Issue: 10(21)

Published: April 29, 2023

Abstract Cells interact with their surrounding environment through a combination of static and dynamic mechanical signals that vary over stimulus types, intensity, space, time. Compared to such as stiffness, porosity, topography, the current understanding on effects stimulations cells remains limited, attributing lack access devices, complexity experimental set‐up, data interpretation. Yet, in pursuit emerging translational applications (e.g., cell manufacturing for clinical treatment), it is crucial understand how respond variety forces are omnipresent vivo so they can be exploited enhance therapeutic outcomes. With rising appreciation extracellular matrix (ECM) key regulator biofunctions, researchers have bioengineered suite ECM‐mimicking hydrogels, which fine‐tuned spatiotemporal cues model complex profiles. This review first discusses stimuli may impact different cellular components various mechanobiology pathways involved. Then, hydrogels designed incorporate parameters influence behaviors described. The Scopus database also used analyze relative strength evidence, ranging from strong weak, based number published literatures, associated citations, treatment significance. Additionally, impacts clinically relevant types including mesenchymal stem cells, fibroblasts, immune evaluated. aim draw attention paucity studies well highlight potential using cocktail intensities fates (similar concept biochemical direct fate). It envisioned this progress report will inspire more exciting development mechanoresponsive biomedical applications.

Language: Английский

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Targeted therapy of kidney disease with nanoparticle drug delivery materials

Bioactive Materials, Journal Year: 2024, Volume and Issue: 37, P. 206 - 221

Published: March 21, 2024

With the development of nanomedicine, nanomaterials have been widely used, offering specific drug delivery to target sites, minimal side effects, and significant therapeutic effects. The kidneys filtration reabsorption functions, with various potential cell types a complex structural environment, making strategies for kidney function protection recovery after injury complex. This also lays foundation application nanomedicine in diseases. Currently, evidence preclinical clinical settings supports feasibility targeted therapy diseases using based on nanomaterials. prerequisite treating is use carriers good biocompatibility, including nanoparticles, hydrogels, liposomes, micelles, dendrimer polymers, adenoviruses, lysozymes, elastin-like polypeptides. These precise renal uptake, longer half-life, organ distribution, protecting improving efficacy drugs they carry. Additionally, attention should be paid toxicity solubility carriers. While mentioned above used studies both vivo vitro, extensive trials are still needed ensure short-term long-term effects nano human body. review will discuss advantages limitations nanoscale carrier materials diseases, provide more comprehensive catalog nanocarrier materials, offer prospects their drug-loading applications.

Language: Английский

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4D bioprinting of programmed dynamic tissues

Bioactive Materials, Journal Year: 2024, Volume and Issue: 37, P. 348 - 377

Published: April 23, 2024

Setting time as the fourth dimension, 4D printing allows us to construct dynamic structures that can change their shape, property, or functionality over under stimuli, leading a wave of innovations in various fields. Recently, smart biomaterials, biological components, and living cells into 3D constructs with effects has led an exciting field bioprinting. bioprinting gained increasing attention is being applied create programmed cell-laden such bone, cartilage, vasculature. This review presents overview on for engineering tissues organs, followed by discussion approaches, technologies, biomaterials design, bioink requirements, applications. While much progress been achieved, complex process facing challenges need be addressed transdisciplinary strategies unleash full potential this advanced biofabrication technology. Finally, we present future perspectives rapidly evolving bioprinting, view its potential, increasingly important roles development basic research, pharmaceutics, regenerative medicine.

Language: Английский

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