Recent Advances in Nanocarrier-Assisted Therapeutics Delivery Systems DOI Creative Commons
Shi Su, Peter M. Kang

Pharmaceutics, Journal Year: 2020, Volume and Issue: 12(9), P. 837 - 837

Published: Sept. 1, 2020

Nanotechnologies have attracted increasing attention in their application medicine, especially the development of new drug delivery systems. With help nano-sized carriers, drugs can reach specific diseased areas, prolonging therapeutic efficacy while decreasing undesired side-effects. In addition, recent nanotechnological advances, such as surface stabilization and stimuli-responsive functionalization also significantly improved targeting capacity nanocarrier assisted system. this review, we evaluate advances different nanocarriers applications therapeutics delivery.

Language: Английский

Dual pH-responsive multifunctional nanoparticles for targeted treatment of breast cancer by combining immunotherapy and chemotherapy DOI
Yuanyuan Liu,

Linan Qiao,

Sipei Zhang

et al.

Acta Biomaterialia, Journal Year: 2017, Volume and Issue: 66, P. 310 - 324

Published: Nov. 10, 2017

Language: Английский

Citations

188

Co-delivery nanoparticles of anti-cancer drugs for improving chemotherapy efficacy DOI Creative Commons
Shanshan Qi,

Jia-Hui Sun,

Hao-Han Yu

et al.

Drug Delivery, Journal Year: 2017, Volume and Issue: 24(1), P. 1909 - 1926

Published: Jan. 1, 2017

To achieve superior therapeutic efficacy, the combination chemotherapy using two or more anticancer drugs in clinical practice has been generally accepted as a feasible strategy. On account of concept chemotherapy, co-delivery with nanotechnology gradually becomes desired strategy and one research frontiers on modern drug delivery. In recent years, nano system (NDCDS), which loads at least different physicochemical pharmacological properties into delivery system, achieved rapid development. NDCDS synergistically inhibited growth tumor compared free drugs. this review, we highlighted current state nanoparticles most commonly used nanomaterial, discussed challenges strategies, prospect future

Language: Английский

Citations

183

Cancer nanotechnology: current status and perspectives DOI Creative Commons

Jessica A. Kemp,

Young Jik Kwon

Nano Convergence, Journal Year: 2021, Volume and Issue: 8(1)

Published: Nov. 2, 2021

Modern medicine has been waging a war on cancer for nearly century with no tangible end in sight. Cancer treatments have significantly progressed, but the need to increase specificity and decrease systemic toxicities remains. Early diagnosis holds key improving prognostic outlook patient quality of life, diagnostic tools are cusp technological revolution. Nanotechnology steadily expanded into reaches chemotherapy, radiotherapy, diagnostics, imaging, demonstrating capacity augment each advance care. Nanomaterials provide an abundance versatility, functionality, applications engineer specifically targeted medicine, accurate early-detection devices, robust imaging modalities, enhanced radiotherapy adjuvants. This review provides insights current clinical pre-clinical nanotechnological drug therapy, radiation therapy.

Language: Английский

Citations

181

Injectable and Self-Healing Thermosensitive Magnetic Hydrogel for Asynchronous Control Release of Doxorubicin and Docetaxel to Treat Triple-Negative Breast Cancer DOI
Wensheng Xie, Qin Gao, Zhenhu Guo

et al.

ACS Applied Materials & Interfaces, Journal Year: 2017, Volume and Issue: 9(39), P. 33660 - 33673

Published: Sept. 13, 2017

Integration of two or more drugs into a multiagent delivery system has been considered to have profound impact on both in vitro and vivo cancer treatment due their efficient synergistic effect. This study presents cheap simple chitosan hydrogel cross-linked with telechelic difunctional poly(ethylene glycol) (DF-PEG-DF) for synthesis an injectable self-healing thermosensitive dual-drug-loaded magnetic (DDMH), which contains doxorubicin (DOX) docetaxel (DTX) chemotherapy iron oxide hyperthermia induced stimuli responsive drug release. The as-prepared DDMH not only good biocompatibility but also exhibit unique self-healing, injectable, asynchronous control release properties. Meanwhile, it shows excellent field heat-inducing property, means that will produce large amount heat the surrounding temperature under alternative (AMF). A remarkably improved effect triple negative breast cell line is obtained by comparing therapeutic codelivery DOX DTX/PLGA nanoparticles (DTX/PLGA NPs) NPs alone. In results showed exhibited significant higher antitumor efficacy reducing tumor size compared single drug-loaded hydrogel. AMF-trigger chemotherapy, indicating was promising field.

Language: Английский

Citations

175

Recent Advances in Nanocarrier-Assisted Therapeutics Delivery Systems DOI Creative Commons
Shi Su, Peter M. Kang

Pharmaceutics, Journal Year: 2020, Volume and Issue: 12(9), P. 837 - 837

Published: Sept. 1, 2020

Nanotechnologies have attracted increasing attention in their application medicine, especially the development of new drug delivery systems. With help nano-sized carriers, drugs can reach specific diseased areas, prolonging therapeutic efficacy while decreasing undesired side-effects. In addition, recent nanotechnological advances, such as surface stabilization and stimuli-responsive functionalization also significantly improved targeting capacity nanocarrier assisted system. this review, we evaluate advances different nanocarriers applications therapeutics delivery.

Language: Английский

Citations

173