Small,
Journal Year:
2024,
Volume and Issue:
20(19)
Published: Jan. 26, 2024
Abstract
Ferroptosis,
characterized
by
the
induction
of
cell
death
via
lipid
peroxidation,
has
been
actively
studied
over
last
few
years
and
shown
potential
to
improve
efficacy
cancer
nanomedicine
in
an
iron‐dependent
manner.
Radiation
therapy,
a
common
treatment
method,
limitations
as
stand‐alone
due
radiation
resistance
safety
it
affects
even
normal
tissues.
Although
ferroptosis‐inducing
drugs
help
alleviate
resistance,
there
are
no
safe
that
can
be
considered
for
clinical
application
still
research
stage.
Here,
effectiveness
combined
with
radiotherapy
Fe
hyaluronic
acid‐based
nanoparticles
(FHA‐NPs)
directly
induce
ferroptosis,
considering
applications
is
reported.
Through
ferroptosis
FHA‐NPs
apoptosis
X‐ray
irradiation,
therapeutic
efficiency
greatly
improved
both
vitro
vivo.
In
addition,
Monte
Carlo
simulations
performed
assess
physical
interactions
X‐rays
iron‐oxide
nanoparticle.
The
study
provides
deeper
understanding
synergistic
effect
irradiation
combination
therapy.
Furthermore,
serve
valuable
reference
elucidating
role
mechanisms
RSC Advances,
Journal Year:
2023,
Volume and Issue:
13(13), P. 8606 - 8629
Published: Jan. 1, 2023
Cancer
is
known
as
the
most
dangerous
disease
in
world
terms
of
mortality
and
lack
effective
treatment.
Research
on
cancer
treatment
still
active
great
social
importance.
Since
1930,
chemotherapeutics
have
been
used
to
treat
cancer.
However,
such
conventional
treatments
are
associated
with
pain,
side
effects,
a
targeting.
Nanomedicines
an
emerging
alternative
due
their
targeting,
bioavailability,
low
toxicity.
Nanoparticles
target
cells
via
passive
mechanisms.
FDA
approval
for
Doxil®,
several
nano-therapeutics
developed,
few
received
use
Along
liposomes,
solid
lipid
nanoparticles,
polymeric
nanoemulsions,
even
newer
techniques
involving
extracellular
vesicles
(EVs)
thermal
nanomaterials
now
being
researched
implemented
practice.
This
review
highlights
evolution
current
status
therapy,
focus
clinical/pre-clinical
nanomedicine
studies.
Insight
also
provided
into
prospects
this
regard.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Aug. 12, 2024
Cancer
remains
a
significant
risk
to
human
health.
Nanomedicine
is
new
multidisciplinary
field
that
garnering
lot
of
interest
and
investigation.
shows
great
potential
for
cancer
diagnosis
treatment.
Specifically
engineered
nanoparticles
can
be
employed
as
contrast
agents
in
diagnostics
enable
high
sensitivity
high-resolution
tumor
detection
by
imaging
examinations.
Novel
approaches
labeling
are
also
made
possible
the
use
nanoprobes
nanobiosensors.
The
achievement
targeted
medication
delivery
therapy
accomplished
through
rational
design
manufacture
nanodrug
carriers.
Nanoparticles
have
capability
effectively
transport
medications
or
gene
fragments
tissues
via
passive
active
targeting
processes,
thus
enhancing
treatment
outcomes
while
minimizing
harm
healthy
tissues.
Simultaneously,
context
radiation
sensitization
photothermal
enhance
therapeutic
efficacy
malignant
tumors.
This
review
presents
literature
overview
summary
how
nanotechnology
used
According
oncological
diseases
originating
from
different
systems
body
combining
pathophysiological
features
cancers
at
sites,
we
most
recent
developments
applications.
Finally,
briefly
discuss
prospects
challenges
cancer.
Pharmaceutical Development and Technology,
Journal Year:
2022,
Volume and Issue:
27(5), P. 525 - 544
Published: May 28, 2022
The
bioavailability
of
drugs
is
dependent
on
several
factors
such
as
solubility
and
the
administration
route.
A
drug
with
poor
aqueous
solubility,
therefore,
poses
challenges
regards
to
its
pharmaceutical
advance
ultimately
biological
usage.
Lipid
nanoparticles
have
been
used
in
science
due
their
importance
green
chemistry.
Their
biochemical
properties
‘green’
materials
processes
mean
they
can
be
environmentally
sustainable.
Generally,
lipid
employed
carriers
for
both
lipophilic
hydrophilic
drugs.
proposed
route
present
advantages
disadvantages
which
should
considered
by
a
formulator.
Solid
(SLNs)
nanostructured
(NLCs)
are
attractive
delivery
systems
because
ease
manufacture,
biocompatibility,
biodegradability,
scale-up
capacity
formulation
constituents.
easy
simple
scalability
novel
SLNs
nano
carriers,
along
various
processing
procedures,
recent
developments,
limitation
toxicity,
optimization
approaches
manufacture
nanoparticles,
lyophilization
release
comprehensively
discussed
this
review.
This
review
also
summarizes
research
data
related
preparation
methods
excipients
NLCs
years.
Cancers,
Journal Year:
2023,
Volume and Issue:
15(8), P. 2256 - 2256
Published: April 12, 2023
Cancer
is
one
of
the
most
prevalent
diseases
globally
and
second
major
cause
death
in
United
States.
Despite
continuous
efforts
to
understand
tumor
mechanisms
various
approaches
taken
for
treatment
over
decades,
no
significant
improvements
have
been
observed
cancer
therapy.
Lack
specificity,
dose-related
toxicity,
low
bioavailability,
lack
stability
chemotherapeutics
are
hindrances
treatment.
Nanomedicine
has
drawn
attention
many
researchers
due
its
potential
tumor-specific
delivery
while
minimizing
unwanted
side
effects.
The
application
these
nanoparticles
not
limited
just
therapeutic
uses;
some
them
shown
extremely
promising
diagnostic
potential.
In
this
review,
we
describe
compare
types
their
role
advancing
We
further
highlight
nanoformulations
currently
approved
therapy
as
well
under
different
phases
clinical
trials.
Finally,
discuss
prospect
nanomedicine
management.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 868 - 868
Published: March 7, 2023
The
new
era
of
nanomedicine
offers
significant
opportunities
for
cancer
diagnostics
and
treatment.
Magnetic
nanoplatforms
could
be
highly
effective
tools
diagnosis
treatment
in
the
future.
Due
to
their
tunable
morphologies
superior
properties,
multifunctional
magnetic
nanomaterials
hybrid
nanostructures
can
designed
as
specific
carriers
drugs,
imaging
agents,
theranostics.
Multifunctional
are
promising
theranostic
agents
due
ability
diagnose
combine
therapies.
This
review
provides
a
comprehensive
overview
development
advanced
combining
optical
providing
photoresponsive
platforms
medical
applications.
Moreover,
this
discusses
various
innovative
developments
using
nanostructures,
including
drug
delivery,
treatment,
tumor-specific
ligands
that
deliver
chemotherapeutics
or
hormonal
resonance
imaging,
tissue
engineering.
Additionally,
artificial
intelligence
(AI)
used
optimize
material
properties
based
on
predicted
interactions
with
cell
membranes,
vasculature,
biological
fluid,
immune
system
enhance
effectiveness
therapeutic
agents.
Furthermore,
an
AI
approaches
assess
practical
utility
Finally,
presents
current
knowledge
perspectives
systems
models.
Biomaterials Research,
Journal Year:
2023,
Volume and Issue:
27(1)
Published: Feb. 9, 2023
Cancer
is
a
disease
caused
by
abnormal
cell
growth
that
spreads
through
other
parts
of
the
body
and
threatens
life
destroying
healthy
tissues.
Therefore,
numerous
techniques
have
been
employed
not
only
to
diagnose
monitor
progress
cancer
in
precise
manner
but
also
develop
appropriate
therapeutic
agents
with
enhanced
efficacy
safety
profiles.
In
this
regard,
molecularly
imprinted
polymers
(MIPs),
synthetic
receptors
recognize
targeted
molecules
high
affinity
selectivity,
intensively
investigated
as
one
most
attractive
biomaterials
for
theragnostic
approaches.
This
review
describes
diverse
synthesis
strategies
provide
rationale
behind
these
antibodies
provides
selective
overview
recent
vitro
vivo
targeting
biomarkers
diagnosis
applications.
Taken
together,
topics
discussed
concise
guidelines
development
novel
MIP-based
systems
more
precisely
promote
successful
treatment.
Molecularly
The
aim
Results in Engineering,
Journal Year:
2024,
Volume and Issue:
23, P. 102720 - 102720
Published: Aug. 10, 2024
Nanostructured
CeO2
was
fabricated
through
a
facile
sonochemical
route
utilizing
cerium
(III)
nitrate
hexahydrate
as
metal
source
and
mentha
extract
novel
capping
agent.
To
our
knowledge,
this
experimental
work
is
the
first
successful
endeavor
for
fabricating
nanostructured
employing
by
an
easy
eco-friendly
route.
The
microstructure
various
characteristics
of
oxide
nanostructure
prepared
were
investigated
using
methods.
This
research
examined
anticancer
effects
green
synthesized
nanoparticles
(CeO2-NPs)
on
cancer
cell
lines
(T98
SHSY5Y)
at
several
concentrations
0.0,
0.05,
0.1,
0.2,
0.4,
0.8
mg/ml
NPs
exposure
time
24/48
h.
obtained
results
presented
cytotoxicity
against
cancerous
lines.
Considering
CeO2-NP's
cells
indicated
significant
toxicity
lines,
these
could
be
applied
in
medicine
developing
new
drug
formulations
Additional
investigations
are
desired
to
reveal
other
biological
applications
normal
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(6), P. 1966 - 2006
Published: Jan. 1, 2024
Neoplasias
pose
a
significant
threat
to
aging
society,
underscoring
the
urgent
need
overcome
limitations
of
traditional
chemotherapy
through
pioneering
strategies.
Targeted
drug
delivery
is
an
evolving
frontier
in
cancer
therapy,
aiming
enhance
treatment
efficacy
while
mitigating
undesirable
side
effects.
One
promising
avenue
utilizes
cell
membrane
receptors
like
folate
receptor
guide
transporters
precisely
malignant
cells.
Based
on
cellular
as
hallmark,
targeted
nanocarriers
and
small
molecule-drug
conjugates
have
been
developed
that
comprise
different
(bio)
chemistries
and/or
mechanical
properties
with
individual
advantages
challenges.
Such
modern
folic
acid-conjugated
stimuli-responsive
provide
systemic
controlled
release,
enabling
reduced
dosages,
circumvention
resistance,
diminished
adverse
Since
transporters'
structure-based
