Highly Efficient Self‐Healing Multifunctional Dressing with Antibacterial Activity for Sutureless Wound Closure and Infected Wound Monitoring

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(3)

Published: Nov. 6, 2021

Wound healing represents a major clinical and public healthcare problem that is frequently challenged by infection risks, detrimental consequences on the surrounding tissues, difficulties to monitor process. Here we report novel self-healing, antibacterial, multifunctional wound dressing for sutureless closure real-time monitoring of parameters. The self-healing elastomer contains cetyltrimethylammonium bromide (CTAB) has high mechanical toughness (35 MJ m-3 ), biocompatibility, outstanding antibacterial activity (bactericidal rate ≈90% in 12 h), enabling effectively inhibit bacterial growth accelerate infected healing. In vivo tests based full-thickness skin incision model shows can help contracting edges facilitate healing, as could be evidenced notably dense well-organized collagen deposition. test provides an evidence integrated sensor array within temperature, pH, glucose level area real-time, providing reliable timely information condition wound. Ultimately, reported would value managing burden associated with via personalised treatment approaches, digital other people-centred solutions health care.

Language: Английский

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A 3D-printed microfluidic-enabled hollow microneedle architecture for transdermal drug delivery

Biomicrofluidics, Journal Year: 2019, Volume and Issue: 13(6)

Published: Nov. 1, 2019

Embedding microfluidic architectures with microneedles enables fluid management capabilities that present new degrees of freedom for transdermal drug delivery. To this end, fabrication schemes can simultaneously create and integrate complex millimeter/centimeter-long structures micrometer-scale microneedle features are necessary. Accordingly, three-dimensional (3D) printing techniques suitable candidates because they allow the rapid realization customizable yet intricate features. However, previously reported 3D-printing approaches utilized costly instrumentation lacked desired versatility to print both in a single step throughput render components within distinct length-scales. Here, first time literature, we devise scheme hollow interfaced step. Our method utilizes stereolithography pushes its boundaries (achieving resolutions below full width half maximum laser spot size resolution) lower cost higher speed than methods. demonstrate potential application, microfluidic-enabled architecture was printed hydrodynamic mixing delivery device. The presented be adopted future biomedical devices facilitate modes operations applications such as combinational therapy preclinical testing biologic treatments.

Language: Английский

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Multifunctional 3D-Printed Wound Dressings

ACS Nano, Journal Year: 2021, Volume and Issue: 15(7), P. 12375 - 12387

Published: June 16, 2021

Personalized wound dressings provide enhanced healing for different types; however multicomponent with discretely controllable delivery of biologically active agents are yet to be developed. Here we report 3D-printed biocomposite hydrogel that have been selectively loaded small molecules, metal nanoparticles, and proteins independently controlled release at the site. Hydrogel carrying antibacterial silver nanoparticles vascular endothelial growth factor predetermined profiles were utilized study physiological response in a mouse model. Compared controls, application resulted improvement granulation tissue formation differential levels density, dependent on profile factor. Our demonstrates versatility can yield varied responses vivo further adapted personalized treatment various types.

Language: Английский

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A review of current advancements for wound healing: Biomaterial applications and medical devices

Journal of Biomedical Materials Research Part B Applied Biomaterials, Journal Year: 2022, Volume and Issue: 110(11), P. 2542 - 2573

Published: May 17, 2022

Wound healing is a complex process that critical in restoring the skin's barrier function. This can be interrupted by numerous diseases resulting chronic wounds represent major medical burden. Such fail to follow stages of and are often complicated pro-inflammatory milieu attributed increased proteinases, hypoxia, bacterial accumulation. The comprehensive treatment still regarded as significant unmet need due symptoms caused metabolic disorder wound microenvironment. As result, several advanced devices, such dressings, wearable monitors, negative pressure therapy surgical sutures, have been developed correct environment achieve skin tissue regeneration. Most devices encompass wide range products containing natural (e.g., chitosan, keratin, casein, collagen, hyaluronic acid, alginate, silk fibroin) synthetic polyvinyl alcohol, polyethylene glycol, poly[lactic-co-glycolic acid], polycaprolactone, polylactic acid) polymers, well bioactive molecules chemical drugs, silver, growth factors, stem cells, plant compounds). review addresses these with focus on biomaterials applications, aiming deliver theoretical reference for further research healing.

Language: Английский

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Electroactive Smart Polymers for Biomedical Applications

Materials, Journal Year: 2019, Volume and Issue: 12(2), P. 277 - 277

Published: Jan. 16, 2019

The flexibility in polymer properties has allowed the development of a broad range materials with electroactivity, such as intrinsically conductive conjugated polymers, percolated composites, and ionic hydrogels. These smart electroactive polymers can be designed to respond rationally under an electric stimulus, triggering outstanding suitable for biomedical applications. This review presents general overview potential applications these field tissue engineering biomaterials. In particular, details about ability to: (1) stimulate cells context by providing electrical current; (2) mimic muscles converting energy into mechanical through electromechanical response; (3) deliver drugs changing their internal configuration stimulus; (4) have antimicrobial behavior due conduction electricity, are discussed.

Language: Английский

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