Small,
Journal Year:
2022,
Volume and Issue:
18(36)
Published: June 17, 2022
The
regeneration
of
3D
tissue
constructs
with
clinically
relevant
sizes,
structures,
and
hierarchical
organizations
for
translational
engineering
remains
challenging.
printing,
an
additive
manufacturing
technique,
has
revolutionized
the
field
by
fabricating
biomimetic
precisely
controlled
composition,
spatial
distribution,
architecture
that
can
replicate
both
biological
functional
native
tissues.
Therefore,
printing
is
gaining
increasing
attention
as
a
viable
option
to
advance
personalized
therapy
various
diseases
regenerating
desired
This
review
outlines
recently
developed
techniques
clinical
translation
specifically
summarizes
applications
these
approaches
cartilage,
bone,
osteochondral
current
challenges
future
perspectives
technology
are
also
discussed.
Materials & Design,
Journal Year:
2023,
Volume and Issue:
226, P. 111661 - 111661
Published: Jan. 27, 2023
Extensive
research
on
nature-inspired
cellular
metamaterials
has
globally
inspired
innovations
using
single
material
and
limited
multifunctionality.
Additive
manufacturing
(AM)
of
intricate
geometries
multi-materials
provides
additional
functionality,
environmental
adaptation,
improved
mechanical
properties.
Recently,
several
studies
have
been
conducted
multi-material
additive
(MMAM)
technologies,
including
multi-materials,
methodologies,
design,
optimization.
However,
in
the
past
six
years,
very
few
or
no
systematic
complete
reviews
this
domain.
This
review
intends
to
comprehensively
summarize
MMAM
systems
working
principles
its
fundamental
processes.
Herein,
Multi-material
combinations
their
modeling,
analysis
strategies
reviewed
systematically.
In
particular,
focus
is
applications
opportunities
for
industries
postprocessing
fabricated
parts.
Furthermore,
identified
limitations
challenges
existing
software
packages,
processes,
materials,
joining
mechanisms,
especially
at
interfaces.
Finally,
we
discuss
possible
overcome
aforementioned
technological
state
future
directions,
which
will
provide
insights
researchers
engineers
designing
complex
objects.
Biomacromolecules,
Journal Year:
2020,
Volume and Issue:
21(6), P. 1968 - 1994
Published: March 31, 2020
Synthetic
3D
extracellular
matrices
(ECMs)
find
application
in
cell
studies,
regenerative
medicine,
and
drug
discovery.
While
cells
cultured
a
monolayer
may
exhibit
unnatural
behavior
develop
very
different
phenotypes
genotypes
than
vivo,
great
efforts
materials
chemistry
have
been
devoted
to
reproducing
vitro
vivo
microenvironments.
This
requires
fine-tuning
the
biochemical
structural
actors
synthetic
ECMs.
review
will
present
fundamentals
of
ECM,
cover
chemical
features
scaffolds
used
generate
ECM
mimics,
discuss
nature
signaling
biomolecules
required
exploited
bioresponsive
microenvironments
able
induce
specific
fate,
highlight
strategies
involved
creating
functional
mimics.
Chemical Reviews,
Journal Year:
2020,
Volume and Issue:
120(19), P. 10608 - 10661
Published: July 31, 2020
Biomaterials-based
biofabrication
methods
have
gained
much
attention
in
recent
years.
Among
them,
3D
cell
printing
is
a
pioneering
technology
to
facilitate
the
recapitulation
of
unique
features
complex
human
tissues
and
organs
with
high
process
flexibility
versatility.
Bioinks,
combinations
printable
hydrogel
cells,
can
be
utilized
create
cell-printed
constructs.
The
bioactive
cues
bioinks
directly
trigger
cells
induce
tissue
morphogenesis.
various
hydrogels,
tissue-
organ-specific
decellularized
extracellular
matrix
(dECM)
exert
synergistic
effects
supporting
at
any
component
by
facilitating
specific
physiological
properties.
In
this
review,
we
aim
discuss
new
paradigm
dECM-based
able
recapitulate
inherent
microenvironmental
niche
This
review
serve
as
toolbox
for
biomedical
engineers
who
want
understand
beneficial
characteristics
basic
set
fundamental
criteria
functional
organs.
IEEE Access,
Journal Year:
2023,
Volume and Issue:
11, P. 12765 - 12795
Published: Jan. 1, 2023
The
rapid
progress
in
digitalization
and
automation
have
led
to
an
accelerated
growth
healthcare,
generating
novel
models
that
are
creating
new
channels
for
rendering
treatment
at
reduced
cost.
Metaverse
is
emerging
technology
the
digital
space
which
has
huge
potential
enabling
realistic
experiences
patients
as
well
medical
practitioners.
a
confluence
of
multiple
technologies
such
artificial
intelligence,
virtual
reality,
augmented
internet
devices,
robotics,
quantum
computing,
etc.
through
directions
providing
quality
healthcare
services
can
be
explored.
amalgamation
these
ensures
immersive,
intimate
personalized
patient
care.
It
also
provides
adaptive
intelligent
solutions
eliminates
barriers
between
providers
receivers.
This
article
comprehensive
review
emphasizing
on
state
art,
adopt
applications,
related
projects.
issues
adaptation
applications
identified
plausible
highlighted
part
future
research
directions.
Small,
Journal Year:
2020,
Volume and Issue:
16(35)
Published: July 30, 2020
Three-dimensional
(3D)
bioprinting
has
recently
advanced
as
an
important
tool
to
produce
viable
constructs
that
can
be
used
for
regenerative
purposes
or
tissue
models.
To
develop
biomimetic
and
sustainable
3D
constructs,
several
processing
aspects
need
considered,
among
which
crosslinking
is
most
achieving
desirable
biomechanical
stability
of
printed
structures,
reflected
in
subsequent
behavior
use
these
constructs.
In
this
work,
methods
studies
are
reviewed,
parameters
affect
bioink
chemistry
discussed,
the
potential
toward
improving
outcomes
construct
performance
highlighted.
Furthermore,
current
challenges
future
prospects
discussed.
Due
direct
connection
between
properties
bioprinted
Review
provide
a
basis
developing
necessary
modifications
design
manufacturing
process
tissue-like
future.
Cells,
Journal Year:
2022,
Volume and Issue:
11(15), P. 2439 - 2439
Published: Aug. 6, 2022
Wound
healing
is
highly
specialized
dynamic
multiple
phase
process
for
the
repair
of
damaged/injured
tissues
through
an
intricate
mechanism.
Any
failure
in
normal
wound
results
abnormal
scar
formation,
and
chronic
state
which
more
susceptible
to
infections.
Chronic
wounds
affect
patients'
quality
life
along
with
increased
morbidity
mortality
are
huge
financial
burden
healthcare
systems
worldwide,
thus
requires
biomedical
intensive
treatment
its
management.
The
clinical
assessment
management
remains
challenging
despite
development
various
therapeutic
regimens
owing
painstakingly
long-term
requirement
complex
Various
conventional
approaches
such
as
cell
therapy,
gene
growth
factor
delivery,
dressings,
skin
grafts
etc.,
being
utilized
promoting
different
types
wounds.
However,
all
these
abovementioned
therapies
not
satisfactory
types,
therefore,
there
urgent
demand
competitive
therapies.
Therefore,
a
pertinent
develop
newer
innovative
modalities
multipart
Recent
developments
advanced
care
technology
includes
nanotherapeutics,
stem
cells
bioengineered
grafts,
3D
bioprinting-based
strategies
improving
outcomes
focus
on
regeneration
minimal
side
effects.
main
objective
this
review
provide
updated
overview
progress
options
over
years
using
next
generation
approaches.
Herein,
we
have
discussed
function
anatomy,
processes,
followed
by
regeneration.
Furthermore,
emerging
bioprinted
skin,
extracellular
matrix-based
approaches,
platelet-rich
plasma-based
cold
plasma
therapy
been
their
benefits
shortcomings.
Finally,
challenges
reviewed
note
future
prospects.
International Journal of Bioprinting,
Journal Year:
2019,
Volume and Issue:
6(1), P. 242 - 242
Published: Nov. 28, 2019
An
additive
manufacturing
technology
based
on
projection
light,
digital
light
processing
(DLP),
three-dimensional
(3D)
printing,
has
been
widely
applied
in
the
field
of
medical
products
production
and
development.
The
precision
reflected
by
a
micromirror
device
million
pixels
instead
one
focused
point,
provides
this
both
printing
accuracy
speed.
In
particular,
relatively
mild
condition
to
cells
due
its
non-direct
contact.
This
review
introduces
DLP-based
3D
applications
medicine,
including
precise
devices,
functionalized
artificial
tissues,
specific
drug
delivery
systems.
are
particularly
discussed
for
their
significance
medicine.
indicates
that
potential
tool
biological
research
clinical
While,
it
is
faced
challenges
scale-up
usage
waiting
period
regulatory
approval.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
121(18), P. 11238 - 11304
Published: April 15, 2021
Degradable
polymers
are
used
widely
in
tissue
engineering
and
regenerative
medicine.
Maturing
capabilities
additive
manufacturing
coupled
with
advances
orthogonal
chemical
functionalization
methodologies
have
enabled
a
rapid
evolution
of
defect-specific
form
factors
strategies
for
designing
creating
bioactive
scaffolds.
However,
these
scaffolds,
especially
when
utilizing
degradable
as
the
base
material,
present
processing
challenges
that
distinct
unique
from
other
classes
materials.
The
goal
this
review
is
to
provide
guide
fabrication
biodegradable
polymer-based
scaffolds
includes
complete
pathway
starting
selecting
materials,
choosing
correct
method,
considering
requirements
specific
applications
scaffold.
