Self-Nano-Emulsifying Drug-Delivery Systems: From the Development to the Current Applications and Challenges in Oral Drug Delivery

Pharmaceutics, Journal Year: 2020, Volume and Issue: 12(12), P. 1194 - 1194

Published: Dec. 9, 2020

Approximately one third of newly discovered drug molecules show insufficient water solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems (SNEDDSs) are the emerging strategies developed to tackle issues associated with their delivery. SNEDDSs composed an oil phase, surfactant, cosurfactant or cosolvent. characteristics, ability dissolve a drug, in vivo considerations determinant factors choice excipients. A SNEDDS formulation can be optimized through phase diagram approach statistical design experiments. The characterization includes multiple orthogonal methods required fully control manufacture, stability, biological fate. Encapsulating lead increased solubilization, stability gastro-intestinal tract, absorption, resulting enhanced transformation liquid into solid dosage forms has been shown increase patient compliance. Supersaturated, mucus-permeating, targeted efficacy Self-emulsification successful present review gives insight for administration both lipophilic hydrophilic compounds from experimental bench marketed products.

Language: Английский

---

Surface Modification of Lipid-Based Nanoparticles

ACS Nano, Journal Year: 2022, Volume and Issue: 16(5), P. 7168 - 7196

Published: April 21, 2022

There is a growing interest in the development of lipid-based nanocarriers for multiple purposes, including recent increase these as vaccine components during COVID-19 pandemic. The number studies that involve surface modification to improve their performance (increase delivery therapeutic its target site with less off-site accumulation) enormous. present review aims provide an overview various methods associated lipid nanoparticle grafting, techniques used separate grafted nanoparticles from unbound ligands or characterize nanoparticles. We also critical perspective on usefulness and true impact modifications overcoming different biological barriers, our prediction what expect near future this field.

Language: Английский

---

Protein Coronas Derived from Mucus Act as Both Spear and Shield to Regulate Transferrin Functionalized Nanoparticle Transcellular Transport in Enterocytes

ACS Nano, Journal Year: 2024, Volume and Issue: 18(10), P. 7455 - 7472

Published: Feb. 28, 2024

The epithelial mucosa is a key biological barrier faced by gastrointestinal, intraoral, intranasal, ocular, and vaginal drug delivery. Ligand-modified nanoparticles demonstrate excellent ability on this process, but their efficacy diminished the formation of protein coronas (PCs) when they interact with matrices. PCs are broadly implicated in affecting fate NPs vivo vitro, yet few studies have investigated formed during interactions mucosa, especially mucus. In study, we constructed transferrin modified (Tf-NPs) as model explored mechanisms effects that had subsequent impact transcellular transport Tf-NPs. mucus-secreting cells, Tf-NPs adsorbed more proteins from mucus layers, which masked, displaced, dampened active targeting Tf-NPs, thereby weakening endocytosis efficiencies. mucus-free intracellular trafficking, enhanced transcytosis related functions. Inspired soft artificial biomimetic membranes, used mucin an "active PC" to precoat (M@Tf-NPs), limited negative impacts "passive PCs" interface improved favorable routes endocytosis. M@Tf-NPs associated endoplasmic reticulum-Golgi functions, prompting exocytosis. summary, shielded against absorption also could be employed spear break through barrier. These findings offer theoretical foundation design platform enhance efficiency oral-administered nanomedicines.

Language: Английский

---

Zeta potential changing self-nanoemulsifying drug delivery systems: A newfangled approach for enhancing oral bioavailability of poorly soluble drugs

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 655, P. 123998 - 123998

Published: March 14, 2024

Language: Английский

---

Recent advances in colon drug delivery systems

Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 327, P. 703 - 724

Published: Sept. 14, 2020

Language: Английский

---

Co-amorphous systems for the delivery of poorly water-soluble drugs: recent advances and an update

Expert Opinion on Drug Delivery, Journal Year: 2020, Volume and Issue: 17(10), P. 1411 - 1435

Published: July 20, 2020

Introduction Most new drug candidates under development are poorly water-soluble, which related to multiple pharmaceutical issues, increasing the bioavailability of these drugs by improvement solubility/dissolution has become a major concern develop efficacious with reasonable dosing regimens for patients. Over past decade, reports have been published on investigation co-amorphous delivery systems, positive and excited outcomes in improving vitro vivo performances water-soluble drugs.Areas covered This review summarizes recent findings systems provides their updates as comprehensive overview terms classification, co-formers selection, preparation methods, physicochemical characteristics performances.Expert opinion Co-amorphous system, homogeneous single-phase system containing two compatible or pharmaceutically acceptable small-molecule co-former, employed promising formulation technology improve such solubility/dissolution, stability, mechanical properties bioavailability. Furthermore, deeper understanding including its detailed criteria co-former stability mechanisms faced challenges well perspectives, will be more conducive application.

Language: Английский

---

Nanoparticle Delivery Systems with Cell-Specific Targeting for Pulmonary Diseases

American Journal of Respiratory Cell and Molecular Biology, Journal Year: 2020, Volume and Issue: 64(3), P. 292 - 307

Published: Oct. 23, 2020

Respiratory disorders are among the most important medical problems threatening human life. The conventional therapeutics for respiratory hindered by insufficient drug concentrations at pathological lesions, lack of cell-specific targeting, and various biobarriers in conducting airways alveoli. To address these critical issues, nanoparticle delivery systems have been developed to serve as carriers specific drugs, DNA expression vectors, RNAs. unique properties nanoparticles, including controlled size distribution, surface functional groups, high payload capacity, release triggering capabilities, tailored requirements drug/gene overcome major barriers pulmonary diseases. avoid off-target effects improve therapeutic efficacy, nanoparticles with cell-targeting specificity essential successful therapies. Furthermore, low toxicity degradability designs. In this review, we provide up-to-date research clinical outcomes therapies We also current issues key areas cell biosafety compatibility, molecular mechanisms selective cellular uptake.

Language: Английский

---

Lipid-Based Nanocarrier System for the Effective Delivery of Nutraceuticals

Molecules, Journal Year: 2021, Volume and Issue: 26(18), P. 5510 - 5510

Published: Sept. 10, 2021

Nutraceuticals possess several health benefits and functions; however, most nutraceuticals are prone to degradation in the gastrointestinal environment have poor bioavailability. Application of a novel carrier system is increasing importance overcome obstacles provide efficient applicability. Lipid-based nanocarriers large surface-to-mass ratio, enhanced intestinal absorption by solubilization milieu, lymphatic transport, altering enterocyte-based transport. A critical overview current limitation, preparation, application lipid-based (liposomes niosomes) lipid nanoparticles (SLNs NLCs) discussed. Physical stability bioavailability nanoencapsulated considered as well.

Language: Английский

---

Mucosal vaccine delivery: A focus on the breakthrough of specific barriers

Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 12(9), P. 3456 - 3474

Published: July 6, 2022

Mucosal vaccines can effectively induce an immune response at the mucosal site and form first line of defense against microbial invasion. The induced immunity includes proliferation effector T cells production IgG IgA antibodies, thereby blocking infection transmission. However, after a long period development, transformation into clinical use is still relatively slow. To date, fewer than ten have been approved. Only seven coronavirus disease 2019 (COVID-19) are under investigation in trials. A representative vaccine adenovirus type-5 vectored COVID-19 (Ad5-nCoV) developed by Chen coworkers, which currently phase III reason for limited progress may be complicated barriers. Therefore, this review summarizes characteristics barriers highlights strategies to overcome these effective delivery.

Language: Английский

---

Recent progress of micro/nanomotors to overcome physiological barriers in the gastrointestinal tract

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 360, P. 514 - 527

Published: July 12, 2023

Language: Английский

---