Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101616 - 101616
Published: Feb. 26, 2025
Language: Английский
EBioMedicine, Journal Year: 2022, Volume and Issue: 83, P. 104237 - 104237
Published: Aug. 27, 2022
Circulating tumor cells (CTCs) are that shed from the primary and intravasate into peripheral blood circulation system responsible for metastasis. Sensitive detection of CTCs clinical samples can serve as an effective tool in cancer diagnosis prognosis through liquid biopsy. Current CTC technologies mainly reply on biomarker-mediated platforms including magnetic beads, microfluidic chips or size-sensitive microfiltration which compromise sensitivity due to heterogeneity. A more sensitive, biomarker independent isolation technique has been recently developed with surface-charged superparamagnetic nanoprobe capable different EMT subpopulation capture 1 mL blood. In this review, new strategy is compared conventional techniques specificity, impact protein corona, effect glycolysis cell surface charge, accurate identification. Correlations between enumeration molecular profiling provided management.
Language: Английский
Citations
169
Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14
Published: July 19, 2023
Various nanoparticles are used in the discovery of new nanomedicine to overcome shortages conventional drugs. Therefore, this article presents a comprehensive and up-to-date review effects nanoparticle-based drugs treatment respiratory disorders, including both basic clinical studies. Databases, PubMed, Web Knowledge, Scopus, were searched until end August 2022 regarding effect on diseases. As tool, offered promising applications for pulmonary The composition intrinsic characteristics nanomaterials showed their effectiveness treating efficiency different nanomedicines has been demonstrated experimental animal models asthma, chronic obstructive disease (COPD), fibrosis (PF), lung cancer, infection, other confirming function improvement disorders. types nanomaterials, such as carbon nanotubes, dendrimers, polymeric liposomes, quantum dots, metal oxide nanoparticles, have therapeutic which may lead possible remedies various illnesses that could increase drug efficacy decrease side effects.
Language: Английский
Citations
42
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: May 15, 2024
With increasing proportion of the elderly in population, age-related diseases (ARD) lead to a considerable healthcare burden society. Prevention and treatment ARD can decrease negative impact aging disease. The rate is closely associated with production high levels reactive oxygen species (ROS). ROS-mediated oxidative stress triggers aging-related changes through lipid peroxidation, protein oxidation, DNA oxidation. Antioxidants control autoxidation by scavenging free radicals or inhibiting their formation, thereby reducing stress. Benefiting from significant advances nanotechnology, large number nanomaterials ROS-scavenging capabilities have been developed. be divided into two categories: as carriers for delivering drugs, themselves activity. This study summarizes current prevention ARD, highlights potential mechanisms used discusses challenges prospects applications.
Language: Английский
Citations
17
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 366, P. 746 - 760
Published: Jan. 20, 2024
Language: Английский
Citations
16
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 136 - 136
Published: Jan. 19, 2025
Nanosuspensions (NS), with their submicron particle sizes and unique physicochemical properties, provide a versatile solution for enhancing the administration of medications that are not highly soluble in water or lipids. This review highlights recent advancements, future prospects, challenges NS-based drug delivery, particularly oral, ocular, transdermal, pulmonary, parenteral routes. The conversion oral NS into powders, pellets, granules, tablets, capsules, incorporation film dosage forms to address stability concerns is thoroughly reviewed. article summarizes key stabilizers, polymers, surfactants, excipients used formulations, along ongoing clinical trials patents. Furthermore, comprehensive analysis various methods preparation provided. also explores vitro vivo characterization techniques, as well scale-down technologies bottom-up preparation. Selected examples commercial products discussed. Rapid advances field could resolve issues related permeability-limited absorption hepatic first-pass metabolism, offering promise based on proteins peptides. evolution novel stabilizers essential overcome current limitations stability, bioavailability, targeting ability, safety profile, which ultimately accelerates application commercialization.
Language: Английский
Citations
3
Current Opinion in Pharmacology, Journal Year: 2020, Volume and Issue: 56, P. 85 - 92
Published: Dec. 18, 2020
Nanotechnology in medicine—nanomedicine—is extensively employed to diagnose, treat, and prevent pulmonary diseases. Over the last few years, this brave new world has made remarkable progress, offering opportunities address historical clinical challenges diseases including multidrug resistance, adverse side effects of conventional therapeutic agents, novel imaging, earlier disease detection. Nanomedicine is also being applied tackle emerging infectious diseases, severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), influenza A virus subtype H1N1 (A/H1N1), more recently, 2 (SARS-CoV-2). In review we provide both a overview application nanomedicine recent cutting-edge approaches such as nanoparticle-mediated combination therapies, double-targeted nondrug delivery system for targeting, stimuli-responsive nanoparticles, theranostic imaging diagnosis treatment
Language: Английский
Citations
74
Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 352, P. 970 - 993
Published: Nov. 16, 2022
Language: Английский
Citations
48
Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)
Published: April 19, 2022
Pulmonary endothelial progenitor cells (EPCs) are critical for neonatal lung angiogenesis and represent a subset of general capillary (gCAPs). Molecular mechanisms through which EPCs stimulate unknown. Herein, we used single-cell RNA sequencing to identify the BMP9/ACVRL1/SMAD1 pathway signature in pulmonary EPCs. BMP9 receptor, ACVRL1, its downstream target genes were inhibited from Foxf1WT/S52F mutant mice, model alveolar dysplasia with misalignment veins (ACDMPV). Expression ACVRL1 targets reduced lungs ACDMPV subjects. Inhibition FOXF1 transcription factor BMP9/ACVRL1 signaling decreased vitro. synergized ETS FLI1 activate promoter. Nanoparticle-mediated silencing newborn mice alveolarization. Treatment restored alveolarization ACVRL1-deficient mice. Altogether, promote FOXF1-mediated activation signaling.
Language: Английский
Citations
45
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: May 4, 2023
Abstract Pulmonary fibrosis results from dysregulated lung repair and involves multiple cell types. The role of endothelial cells (EC) in is poorly understood. Using single RNA-sequencing we identified transcription factors involved fibrogenesis, including FOXF1, SMAD6, ETV6 LEF1. Focusing on found that FOXF1 decreased EC within human idiopathic pulmonary (IPF) mouse bleomycin-injured lungs. Endothelial-specific Foxf1 inhibition mice increased collagen depositions, promoted inflammation, impaired R-Ras signaling. In vitro, FOXF1-deficient proliferation, invasion activation fibroblasts, stimulated macrophage migration by secreting IL-6, TNFα, CCL2 CXCL1. inhibited TNFα through direct transcriptional Rras gene promoter. Transgenic overexpression or endothelial-specific nanoparticle delivery cDNA mice. Nanoparticle can be considered for future therapies IPF.
Language: Английский
Citations
39
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 204, P. 115143 - 115143
Published: Nov. 24, 2023
Language: Английский
Citations
28