Nanomaterials Responsive to Endogenous Biomarkers for Cardiovascular Disease Theranostics

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(26)

Published: March 31, 2023

Abstract Cardiovascular disease (CVD) is the number one cause of death worldwide, which propels development advanced technologies for CVD diagnosis and treatment. Biomarker‐responsive nanomaterials are appealing therapeutic platforms that provide new horizons theranostics. In this review, recent advances in with endogenous biomarkers as stimuli or targets theranostics presented. First, categories involved comprehensively itemized based on pathological mechanisms including pH, reactive oxygen species, lipids, enzymes, macrophage receptors, subendothelium components, platelet inflammation, osteopontin. The role these bridge‐building between then Next, biomedical applications responsive to treatment elaborated. Finally, challenges future research directions biomarker‐responsive also discussed. This review will scientific guidance facilitate clinical nanomaterials.

Language: Английский

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The Role of Vitamin D in Reducing the Risk of Metabolic Disturbances That Cause Cardiovascular Diseases

Journal of Cardiovascular Development and Disease, Journal Year: 2023, Volume and Issue: 10(5), P. 209 - 209

Published: May 11, 2023

Among the most common problems facing public health today is a lack of vitamin D, which plays role in physiological processes chronic illness conditions. Vitamin D deficiency metabolic disorders has primary effects on osteoporosis, obesity, hypertension, diabetes, and cardiovascular disease (CVD). acts as “co-hormone” various tissues body, it been found that receptors (VDR) are present all cell types, suggesting wide range cells. Recently, there surge interest assessing its roles. insufficiency increases risk diabetes because lowers insulin sensitivity, also raises obesity CVD effect body’s lipid profile, particularly terms prevalence dangerously high levels low-density lipoproteins (LDL). Furthermore, often related to connected factors, highlighting need know D’s functions relation syndrome processes. Through looking at previous studies, this paper explains why important, how factors for through different mechanisms, affects CVD.

Language: Английский

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Effects of different n-6/n-3 polyunsaturated fatty acids ratios on lipid metabolism in patients with hyperlipidemia: a randomized controlled clinical trial

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: June 1, 2023

Intake of n-3 polyunsaturated fatty acids (PUFA) is helpful for cardiometabolic health. It improves lipid metabolism, and increasing PUFA often considered beneficial. However, the role n-6/n-3 in regulation metabolism has been much debated. Therefore, this study was performed on effect different proportions diet quality life patients with hyperlipidemia, aiming to explore appropriate provide theoretical basis development application nutritional blended oil future.These 75 participants were randomized assigned into three groups, which received dietary high ratios (HP group: = 7.5/1), middle (MP 2.5/1) or low (LP 1/2.5). All guidance health education monitored hyperlipidemia. Anthropometric, blood glucose parameters assessed at baseline 60 days after intervention.After days, high-density lipoprotein cholesterol (HDL-c) level increased (p 0.029) Total (TC) decreased 0.003) MP group. In LP group, TC 0.001), TG but HDL-c not significantly increased. At end intervention, life' score improved both groups 0.037).Decreasing intake edible ratio can improve lipids life. This significant prevention cardiovascular disease (CVD). also essential note that an excessive reduction does further metabolism. addition, perilla particular significance.https://www.chictr.org.cn/indexEN.html, identifier ChiCTR-2300068198.

Language: Английский

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Effects of Combined Interventions of Exercise and Diet or Exercise and Supplementation on Breast Cancer Patients: A Systematic Review

Nutrients, Journal Year: 2023, Volume and Issue: 15(4), P. 1013 - 1013

Published: Feb. 17, 2023

This systematic review investigated the effects of exercise interventions combined with diet and/or dietary supplement on anthropometry, body composition, metabolic biomarkers, physical function, healthy lifestyles, quality life, psychosocial variables and fatigue for women breast cancer. A search was performed in PubMed Web Science databases (from inception to 1 March 2022). carried out following Preferred Reporting Items Systematic Meta-Analyses (PRISMA) guidelines. The methodological risk bias included studies assessed Physiotherapy Evidence Database (PEDro) scale. total 13 randomised controlled trial were included, comprising 1569 cancer patients. main finding this is that groups performing combining plus show significant improvements cardiorespiratory fitness, muscular strength, fatigue, anxiety, depression sleep compared control groups. On other hand, use supplementation does not result an improvement using alone or alone.

Language: Английский

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Investigating Performance of the SLIM-Based High Resolution Ion Mobility Platform for Separation of Isomeric Phosphatidylcholine Species

Journal of the American Society for Mass Spectrometry, Journal Year: 2023, Volume and Issue: 34(10), P. 2176 - 2186

Published: Sept. 13, 2023

Lipids are structurally diverse molecules that play a pivotal role in plethora of biological processes. However, deciphering the roles specific lipids is challenging due to existence numerous isomers. This high chemical complexity lipidome one major challenges lipidomics research, as traditional liquid chromatography-mass spectrometry (LC-MS) based approaches often not powerful enough resolve these isomeric and isobaric nuances within complex samples. Thus, uniquely suited benefits provided by multidimensional chromatography-ion mobility-mass (LC-IM-MS) analysis. many forms lipid isomerism, including double-bond positional isomers regioisomers, similar such their collision cross section (CCS) differences unresolvable via conventional IM approaches. Here we evaluate performance resolution ion mobility (HRIM) system on structures for lossless manipulation (SLIM) technology interfaced quadrupole time-of-flight (QTOF) analyzer address noted lipidomic isomerism challenge. SLIM implements traveling wave technique along an ∼13 m path, providing longer path lengths enable improved separation features. We demonstrate power HRIM-MS dissect PC standards differing only double bond (DB) stereospecific number (SN) positions. The partial protonated DB significantly enhanced when they analyzed metal adducts. For sodium adducts, achieve close baseline three different 18:1/18:1 with cis-double locations. Similarly, (cis-9) can be resolved from corresponding (trans-9) form. capacity further using silver doping, enabling regioisomers cannot measured sensitivity reproducibility approach were assessed, more mixtures was benchmarked identifying total brain liver extracts.

Language: Английский

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