Protein and Peptide‐Based Nanotechnology for Enhancing Stability, Bioactivity, and Delivery of Anthocyanins DOI Creative Commons
Lei Zhang, Liang Yao, Feng Zhao

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(25)

Published: Aug. 3, 2023

Anthocyanin, a unique natural polyphenol, is abundant in plants and widely utilized biomedicine, cosmetics, the food industry due to its excellent antioxidant, anticancer, antiaging, antimicrobial, anti-inflammatory properties. However, degradation of anthocyanin an extreme environment, such as alkali pH, high temperatures, metal ions, limits physiochemical stabilities bioavailabilities. Encapsulation combining with biomaterials could efficiently stabilize for protection. Promisingly, or artificially designed proteins peptides favorable stabilities, biocapacity, wide sources are potential candidates anthocyanin. This review focuses on recent progress, strategies, perspectives protein peptide functionalization delivery, i.e., formulation technologies, physicochemical stability enhancement, cellular uptake, bioavailabilities, biological activities development. Interestingly, simplicity diversity structure, interaction mechanisms between be illustrated. work sheds light mechanism protein/peptide-anthocyanin nanoparticle construction expands applications nutrition biomedicine.

Language: Английский

Injectable liposome-based supramolecular hydrogels for the programmable release of multiple protein drugs DOI Creative Commons
Santiago Correa, Abigail K. Grosskopf, John H. Klich

et al.

Matter, Journal Year: 2022, Volume and Issue: 5(6), P. 1816 - 1838

Published: March 21, 2022

Language: Английский

Citations

40
Self-assembling nanocarriers from engineered proteins: Design, functionalization, and application for drug delivery DOI
Yirui Li, Yirui Li

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 189, P. 114462 - 114462

Published: Aug. 4, 2022

Language: Английский

Citations

38
PeptideBERT: A Language Model Based on Transformers for Peptide Property Prediction DOI Creative Commons
Chakradhar Guntuboina,

Adrita Das,

Parisa Mollaei

et al.

The Journal of Physical Chemistry Letters, Journal Year: 2023, Volume and Issue: 14(46), P. 10427 - 10434

Published: Nov. 13, 2023

Recent advances in language models have enabled the protein modeling community with a powerful tool that uses transformers to represent sequences as text. This breakthrough enables sequence-to-property prediction for peptides without relying on explicit structural data. Inspired by recent progress field of large models, we present PeptideBERT, model specifically tailored predicting essential peptide properties such hemolysis, solubility, and nonfouling. The PeptideBERT utilizes ProtBERT pretrained transformer 12 attention heads hidden layers. Through fine-tuning three downstream tasks, our is state art (SOTA) which crucial determining peptide's potential induce red blood cells well nonfouling properties. Leveraging primarily shorter data set negative samples predominantly associated insoluble peptides, showcases remarkable performance.

Language: Английский

Citations

30
Advances in formulation and manufacturing strategies for the delivery of therapeutic proteins and peptides in orally disintegrating dosage forms DOI Creative Commons
Shazia Bashir, Rawan Fitaihi, Hend E. Abdelhakim

et al.

European Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 182, P. 106374 - 106374

Published: Jan. 7, 2023

Therapeutic proteins and peptides (TPPs) are increasingly favoured above small drug molecules due to their high specificity the site of action reduced adverse effects resulting in increased use these agents for medical treatments therapies. Consequently, there is a need formulate TPPs dosage forms that accessible suitable wide range patient groups as becomes prevalent healthcare settings worldwide. Orally disintegrating (ODDF) formulations can ensure easy-to-administer medication wider population including paediatrics, geriatrics people low-resource countries. There many challenges involved developing pharmaceutical strategies protect during formulation manufacturing, well storage, maintenance cold-chain transportation. This review will discuss advances being made research development manufacturing used incorporate various into ODDF systems.

Language: Английский

Citations

29
Protein and Peptide‐Based Nanotechnology for Enhancing Stability, Bioactivity, and Delivery of Anthocyanins DOI Creative Commons
Lei Zhang, Liang Yao, Feng Zhao

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(25)

Published: Aug. 3, 2023

Anthocyanin, a unique natural polyphenol, is abundant in plants and widely utilized biomedicine, cosmetics, the food industry due to its excellent antioxidant, anticancer, antiaging, antimicrobial, anti-inflammatory properties. However, degradation of anthocyanin an extreme environment, such as alkali pH, high temperatures, metal ions, limits physiochemical stabilities bioavailabilities. Encapsulation combining with biomaterials could efficiently stabilize for protection. Promisingly, or artificially designed proteins peptides favorable stabilities, biocapacity, wide sources are potential candidates anthocyanin. This review focuses on recent progress, strategies, perspectives protein peptide functionalization delivery, i.e., formulation technologies, physicochemical stability enhancement, cellular uptake, bioavailabilities, biological activities development. Interestingly, simplicity diversity structure, interaction mechanisms between be illustrated. work sheds light mechanism protein/peptide-anthocyanin nanoparticle construction expands applications nutrition biomedicine.

Language: Английский

Citations

29