Micro(nano)plastics pollution and human health: How plastics can induce carcinogenesis to humans?

Chemosphere, Journal Year: 2022, Volume and Issue: 298, P. 134267 - 134267

Published: March 14, 2022

Language: Английский

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Immunosuppression in tumor immune microenvironment and its optimization from CAR-T cell therapy

Theranostics, Journal Year: 2022, Volume and Issue: 12(14), P. 6273 - 6290

Published: Jan. 1, 2022

Chimeric antigen receptor (CAR)-T cell therapy represents a landmark advance in personalized cancer treatment.CAR-T strategy generally engineers T cells from specific patient with new antigen-specificity, which has achieved considerable success hematological malignancies, but scarce benefits solid tumors.Recent studies have demonstrated that tumor immune microenvironment (TIME) cast profound impact on the immunotherapeutic response.The immunosuppressive landscape of TIME is critical obstacle to effector activity CAR-T cells.Nevertheless, every cloud silver lining.The components also shed inspiration reshaping friendly by targeting them engineered CARs.Herein, we summarize recent advances disincentives and discuss approaches technologies enhance efficacy via addressing current hindrances.Simultaneously, firmly believe parsing TIME, rationally manipulating complex interactions components, optimizing for each patient, immunotherapy responsiveness malignancies will be substantially enhanced, novel therapeutic targets revealed.

Language: Английский

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Organs-on-chips technologies – A guide from disease models to opportunities for drug development

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 231, P. 115271 - 115271

Published: March 31, 2023

Current in-vitro 2D cultures and animal models present severe limitations in recapitulating human physiopathology with striking discrepancies estimating drug efficacy side effects when compared to trials. For these reasons, microphysiological systems, organ-on-chip multiorgans microdevices attracted considerable attention as novel tools for high-throughput high-content research achieve an improved understanding of diseases accelerate the development process towards more precise eventually personalized standards. This review takes form a guide on this fast-growing field, providing useful introduction major themes indications further readings. We start analyzing Organs-on-chips (OOC) technologies testing administration routes: (1) oral/rectal route by intestine-on-a-chip, (2) inhalation lung-on-a-chip, (3) transdermal skin-on-a-chip (4) intravenous through vascularization models, considering how drugs penetrate bloodstream are conveyed their targets. Then, we focus OOC (other) specific organs diseases: neurodegenerative brain blood barriers, tumor including vascularization, organoids/spheroids, engineering screening antitumor drugs, liver/kidney chips multiorgan gastrointestinal metabolic assessment biomechanical systems heart, muscles bones structures related diseases. Successively, discuss materials organ chips, microfluidic organs-on-chips, sensor integration real-time monitoring, cell lines chips. (Nano)delivery approaches therapeutics chip also described. Finally, conclude critical discussion current significance/relevance, trends, limitations, challenges future prospects terms revolutionary impact biomedical research, preclinical development.

Language: Английский

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Emerging organoid-immune co-culture models for cancer research: from oncoimmunology to personalized immunotherapies

Journal for ImmunoTherapy of Cancer, Journal Year: 2023, Volume and Issue: 11(5), P. e006290 - e006290

Published: May 1, 2023

In the past decade, treatments targeting immune system have revolutionized cancer treatment field. Therapies such as checkpoint inhibitors been approved first-line in a variety of solid tumors melanoma and non-small cell lung while other therapies, for instance, chimeric antigen receptor (CAR) lymphocyte transfer are still development. Although promising results obtained small subset patients, overall clinical efficacy most immunotherapeutics is limited due to intertumoral heterogeneity therapy resistance. Therefore, prediction patient-specific responses would be great value efficient use costly immunotherapeutic drugs well better outcomes. Because many operate by enhancing interaction and/or recognition malignant target cells T cells, vitro cultures using combination these derived from same patient hold promise predict drug personalized fashion. The two-dimensional lines unreliable altered phenotypical behavior when compared with vivo situation. Three-dimensional tumor-derived organoids, mimic tissue deemed more realistic approach study complex tumor-immune interactions. this review, we present an overview development tumor organoid-immune co-culture models tumor-specific interactions their possible therapeutic infringement. We also discuss applications which advance understanding microenvironment as: (1) Screening inhibition CAR screening manner. (2) Generation reactive lymphocytes adoptive therapies. (3) Studying detect cell-specific roles progression remission. Overall, onco-immune co-cultures might future toward developing approaches increase our

Language: Английский

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Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities

Journal of Hematology & Oncology, Journal Year: 2021, Volume and Issue: 14(1)

Published: Aug. 17, 2021

B-cell lymphoma is a group of hematological malignancies with high clinical and biological heterogeneity. The pathogenesis involves complex interaction between tumor cells the microenvironment (TME), which composed stromal extracellular matrix. Although roles TME have not been fully elucidated, accumulating evidence implies that closely relevant to origination, invasion metastasis lymphoma. Explorations provide distinctive insights for cancer therapy. Here, we epitomize recent advances in discuss its function progression immune escape. In addition, potential value targeting highlighted, expected pave way novel therapeutic strategies.

Language: Английский

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Fusobacterium nucleatum Acts as a Pro-carcinogenic Bacterium in Colorectal Cancer: From Association to Causality

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 9

Published: Aug. 20, 2021

Colorectal cancer (CRC) is a common worldwide with complex etiology. Fusobacterium nucleatum ( F. ), an oral symbiotic bacterium, has been linked CRC in the past decade. A series of gut microbiota studies show that patients carry high abundance tumor tissue and fecal, etiological have clarified role as pro-carcinogenic bacterium various stages CRC. In this review, we summarize biological characteristics epidemiological associations between CRC, then highlight mechanisms by which participates progression, metastasis, chemoresistance affecting cells or regulating microenvironment (TME). We also discuss research gap field give our perspective for future studies. These findings will pave way manipulating to deal future.

Language: Английский

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Immunotherapy discovery on tumor organoid-on-a-chip platforms that recapitulate the tumor microenvironment

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 187, P. 114365 - 114365

Published: June 4, 2022

Language: Английский

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Emerging tumor-on-chips with electrochemical biosensors

TrAC Trends in Analytical Chemistry, Journal Year: 2022, Volume and Issue: 153, P. 116640 - 116640

Published: April 15, 2022

Language: Английский

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New Strategy for Promoting Vascularization in Tumor Spheroids in a Microfluidic Assay

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 12(14)

Published: Nov. 5, 2022

Abstract Previous studies have developed vascularized tumor spheroid models to demonstrate the impact of intravascular flow on progression and treatment. However, these not been widely adopted so vascularization spheroids in vitro is generally lower than tissues vivo. To improve level, a new strategy introduced form by adding fibroblasts (FBs) sequentially pre‐formed this method with cell lines from kidney, lung, ovary cancer. Tumor made higher FB densities periphery spheroid, which tend enhance vascularization. The vessels close are more perfusable ones other methods. Finally, chimeric antigen receptor (CAR) T cells perfused under continuous into immunotherapy evaluation using tumor‐on‐a‐chip model. This for establishing leads increased vitro, allowing examination immune, endothelial, stromal, responses static or conditions.

Language: Английский

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Recent Advances of Organ-on-a-Chip in Cancer Modeling Research

Biosensors, Journal Year: 2022, Volume and Issue: 12(11), P. 1045 - 1045

Published: Nov. 18, 2022

Although many studies have focused on oncology and therapeutics in cancer, cancer remains one of the leading causes death worldwide. Due to unclear molecular mechanism complex vivo microenvironment tumors, it is challenging reveal nature develop effective therapeutics. Therefore, development new methods explore role heterogeneous TME individual patients’ drug response urgently needed critical for therapeutic management cancer. The organ-on-chip (OoC) platform, which integrates technology 3D cell culture, tissue engineering, microfluidics, emerging as a method simulate structures tumor functional characteristics. It overcomes failure traditional 2D/3D culture models preclinical animal completely replicate human tumors. As brand-new technology, OoC great significance realization personalized treatment drugs. This review discusses recent advances biology studies. focuses design principles devices associated applications modeling. challenges future this field are also summarized review. displays broad technique has reference value development.

Language: Английский

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