Recent Advances of Tumor Microenvironment-Responsive Nanomedicines-Energized Combined Phototherapy of Cancers DOI Creative Commons

Kehan Liu,

Yao Yao,

Shujuan Xue

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(10), P. 2480 - 2480

Published: Oct. 17, 2023

Photodynamic therapy (PDT) has emerged as a powerful tumor treatment tool due to its advantages including minimal invasiveness, high selectivity and thus dampened side effects. On the other side, efficacy of PDT is severely frustrated by limited oxygen level in tumors, promoting combination with therapies, particularly photothermal (PTT) for bolstered outcomes. Meanwhile, nanomedicines that could respond various stimuli microenvironment (TME) provide tremendous benefits combined phototherapy efficient hypoxia relief, tailorable drug release activation, improved cellular uptake intratumoral penetration nanocarriers, etc. In this review, we will introduce merits combining PTT PDT, summarize recent important progress phototherapies their combinations dominant regimen, chemotherapy based on smart sensitive TME focus sophisticated designs, discuss challenges future developments nanomedicine-mediated phototherapies.

Language: Английский

Nanoparticle-based drug delivery systems targeting cancer cell surfaces DOI Creative Commons

Liquan Hong,

Wen Li, Yang Li

et al.

RSC Advances, Journal Year: 2023, Volume and Issue: 13(31), P. 21365 - 21382

Published: Jan. 1, 2023

This review focuses on the research progress of various receptors overexpressed surface cancer cells and different nano-delivery systems anticancer drugs targeted cells.

Language: Английский

Citations

57
Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer DOI Creative Commons
Chunmei Zhang, Ning Liu

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: July 25, 2022

Ovarian cancer (OC) is one of the most common malignancies that causes death in women and a heterogeneous disease with complex molecular genetic changes. Because relatively high recurrence rate OC, it crucial to understand associated mechanisms drug resistance discover potential target for rational targeted therapy. Cell genetically determined process. Active orderly cell prevalent during development living organisms plays critical role regulating life homeostasis. Ferroptosis, novel type discovered recent years, distinct from apoptosis necrosis mainly caused by imbalance between production degradation intracellular lipid reactive oxygen species triggered increased iron content. Necroptosis regulated non-cysteine protease–dependent programmed necrosis, morphologically exhibiting same features as occurring via unique mechanism different apoptotic signaling pathway. Pyroptosis form characterized formation membrane pores subsequent lysis well release pro-inflammatory contents mediated abscisin family. Studies have shown ferroptosis, necroptosis, pyroptosis are involved progression variety diseases, including tumors. In this review, we summarized advances occurrence, development, therapeutic OC.

Language: Английский

Citations

56
The highly effective therapy of ovarian cancer by Bismuth-doped oxygen-deficient BaTiO3 with enhanced sono-piezocatalytic effects DOI

Shuangshuang Cheng,

Yue Luo,

Jun Zhang

et al.

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 442, P. 136380 - 136380

Published: April 13, 2022

Language: Английский

Citations

50
Nanomedicine Strategies for Heating “Cold” Ovarian Cancer (OC): Next Evolution in Immunotherapy of OC DOI
Yuqi Yang, Tianjiao Zhao, Qiaohui Chen

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 9(28)

Published: July 22, 2022

Immunotherapy has revolutionized cancer treatment, dramatically improving survival rates of melanoma and lung patients. Nevertheless, immunotherapy is almost ineffective against ovarian (OC) due to its cold tumor immune microenvironment (TIM). Many traditional medications aimed at remodeling TIM are often associated with severe systemic toxicity, require frequent dosing, show only modest clinical efficacy. In recent years, emerging nanomedicines have demonstrated extraordinary immunotherapeutic effects for OC by reversing the because physical biochemical features can all be harnessed obtain optimal expected tissue distribution cellular uptake. However, far from being widely explored in field lack appreciation professional barriers nanomedicine pathology, limiting horizons biomedical researchers materials scientists. Herein, a typical tumor-OC adopted as paradigm introduce classification TIM, characteristics OC, advantages immunotherapy. Subsequently, current comprehensively summarized through five general strategies substantially enhance efficacy heating OC. Finally, challenges perspectives this expanding improved development applications also discussed.

Language: Английский

Citations

40
Hybrid Ginseng‐derived Extracellular Vesicles‐Like Particles with Autologous Tumor Cell Membrane for Personalized Vaccination to Inhibit Tumor Recurrence and Metastasis DOI Creative Commons
Haoran Wang,

Jian-Kang Mu,

Yexing Chen

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(17)

Published: Feb. 14, 2024

Abstract Personalized cancer vaccines based on resected tumors from patients is promising to address tumor heterogeneity inhibit recurrence or metastasis. However, it remains challenge elicit immune activation due the weak immunogenicity of autologous antigens. Here, a hybrid membrane vaccine successfully constructed by fusion enhance adaptive response and amplify personalized immunotherapy, which formed codelivery system for antigens adjuvants. Briefly, functional vesicles (HM‐NPs) are hybridizing ginseng‐derived extracellular vesicles‐like particles (G‐EVLPs) with originated tumors. The introduction G‐EVLPs can phagocytosis dendritic cells (DCs) facilitate DCs maturation through TLR4, ultimately activating tumor‐specific cytotoxic T lymphocytes (CTLs). HM‐NPs indeed strengthen specific responses suppress metastasis including subcutaneous orthotopic Furthermore, long‐term protection be obtained after vaccinating HM‐NPs, prolonging survival animals. Overall, this provides possibility mitigating surgery while maintaining good biocompatibility.

Language: Английский

Citations

14
Drug tolerant persister cell plasticity in cancer: A revolutionary strategy for more effective anticancer therapies DOI Creative Commons
Jun He,

Zejing Qiu,

Jingjing Fan

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 14, 2024

Non-genetic mechanisms have recently emerged as important drivers of anticancer drug resistance. Among these, the tolerant persister (DTP) cell phenotype is attracting more and attention giving a predominant non-genetic role in cancer therapy The DTP characterized by quiescent or slow-cell-cycle reversible state subpopulation inert specialization to stimuli, which tolerates exposure some extent through interaction multiple underlying recovering growth proliferation after withdrawal, ultimately leading treatment resistance recurrence. Therefore, targeting cells anticipated provide new opportunities for patients, although our current knowledge these remains limited. In this review, we comprehensive overview formation characteristics cells, investigate potential drugs (including preclinical drugs, novel use old natural products) based on different medicine models, discuss necessity feasibility anti-DTP therapy, related application forms, future issues that will need be addressed advance emerging field towards clinical applications. Nonetheless, understanding functions may enable us develop effective improve outcomes patients.

Language: Английский

Citations

11
N6‐methyladenosine (m6A) modification in gynecological malignancies DOI
Chunmei Zhang, Ning Liu

Journal of Cellular Physiology, Journal Year: 2022, Volume and Issue: 237(9), P. 3465 - 3479

Published: July 8, 2022

N6-methyladenosine (m6A) modification is one of the most abundant modifications in eukaryotic mRNA, regulated by m6A methyltransferase and demethylase. modified RNA specifically recognized bound recognition proteins, which mediate splicing, maturation, exonucleation, degradation, translation. In gynecologic malignancies, modification-related molecules are expressed aberrantly, significantly altering posttranscriptional methylation level target genes their stability. The also regulates related metabolic pathways, thereby controlling tumor development. This review analyzes composition mode action proteins biological functions malignant progression provide new ideas for early clinical diagnosis targeted therapy malignancies.

Language: Английский

Citations

30
Recent advances in aptamer-based therapeutic strategies for targeting cancer stem cells DOI Creative Commons
Biao Liu, Jiahao Liu, Xing Hu

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100605 - 100605

Published: March 11, 2023

Cancer stem cells (CSCs) are believed to be the main cause of chemotherapy resistance and tumor relapse. Various therapeutic strategies eliminate CSCs have been developed recently. Aptamers, also called "chemical antibodies", can specifically bind with their molecular targets through special tertiary structures. The advantages aptamers, such as lower immunogenicity smaller size, make them superior conventional antibodies. Therefore, aptamers used widely targeting ligands for CSC-targeted in different types. To date, various cargoes conjugated kill CSCs, drugs, small interfering RNAs, microRNAs. Aptamer-based targeted therapies made great progress recent years, especially development multifunctional aptamer-based strategies. Besides, cell-systematic evolution by exponential enrichment has applied screen new that might a higher binding ability CSCs. In this review, we focus on advances introduce some modalities aptamer-drug conjugates against Some considerations limitations discussed.

Language: Английский

Citations

19
Triple targeting host–guest drug delivery system based on lactose-modified azocalix[4]arene for tumor ablation DOI
Juanjuan Li,

Rui-Xue Rong,

Yan Yang

et al.

Materials Horizons, Journal Year: 2023, Volume and Issue: 10(5), P. 1689 - 1696

Published: Jan. 1, 2023

The supramolecular nanoformulation DOX@LacAC4A integrates passive, active and stimuli-responsive targeting capabilities. It can improve drug accumulation at tumor sites effectively suppress the growth of cells.

Language: Английский

Citations

16
Targeted drug conjugate systems for ovarian cancer chemotherapy DOI Creative Commons

Omotola D. Ogundipe,

Oluwabukunmi Olajubutu, Simeon K. Adesina

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115151 - 115151

Published: July 18, 2023

Ovarian cancer is a highly lethal disease that affects women. Early diagnosis and treatment of women with early-stage improve the probability survival. Unfortunately, majority ovarian are diagnosed at advanced stages 3 4 which makes challenging. While patients respond to first-line treatment, i.e. cytoreductive surgery integrated platinum-based chemotherapy, rate recurrence very high available options for recurrent not curative. Thus, there need more effective cancer. Targeted drug conjugate systems have emerged as promising therapeutic strategy These provide opportunity selectively deliver potent chemotherapeutic drugs cancer, sparing healthy normal cells. effectiveness improved systemic toxicity greatly reduced. In this review, different targeted been or being developed will be discussed.

Language: Английский

Citations

16