APOPTOSIS, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 2, 2024
Language: Английский
Drug Resistance Updates, Journal Year: 2022, Volume and Issue: 66, P. 100916 - 100916
Published: Dec. 29, 2022
Language: Английский
Citations
163
International Immunopharmacology, Journal Year: 2022, Volume and Issue: 114, P. 109608 - 109608
Published: Dec. 20, 2022
Ferroptosis plays a critical role in LPS-induced acute lung injury and is modulated by endoplasmic reticulum stress (ERS). As typical ER stress-responsive protein, recently mesencephalic astrocyte-derived neurotrophic factor (MANF) has been demonstrated to attenuate (ALI) through repressing macrophage activation. However, whether MANF exerts preventive on ferroptosis excess remains unclear. Here, we first built protein-protein interaction (PPI) network obtain potential interacting proteins related STRING GeneMANIA. Then, male C57BL/6J mice were used build model of injury. Two days before LPS injection, the tail vein injected recombinant murine (rmMANF) at 750 μg/kg. Twenty-four hours after histopathological changes damage tissues detected scored HE staining TUNEL assay, respectively. Endogenous levels, oxidative markers (GSH, SOD, CAT, MDA), ERS (GRP78, PERK, ATF4), (iron, GPX4, 4-HNE) measured IHC, western blotting, commercial kits. Our results showed that induced significant increase MPO, MDA, 4-HNE, decrease GPX4 GSH, total iron accumulation LPS-exposed mice. Simultaneously, GRP78/PERK/ATF4 pathway was notably activated LPS, accompanied down-regulation MANF. Furthermore, rmMANF pretreatment markedly prevented tissue characteristics with increased level sepsis Finally, found activation significantly restrained pretreatment, except for endogenous level. Overall, can prevent sepsis-associated inhibiting stress-induced
Language: Английский
Citations
43
Journal of Inflammation Research, Journal Year: 2023, Volume and Issue: Volume 16, P. 2727 - 2754
Published: June 30, 2023
Bronchial asthma is a complex heterogeneous airway disease, which has emerged as global health issue. A comprehensive understanding of the different molecular mechanisms bronchial may be an efficient means to improve its clinical efficacy in future. Increasing research evidence indicates that some types programmed cell death (PCD), including apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis, contributed pathogenesis, become new targets for future treatment. This review briefly discusses mechanism signaling pathway these forms PCD focuses on summarizing their roles pathogenesis treatment strategies offers therapeutics near
Language: Английский
Citations
36
Cell Proliferation, Journal Year: 2024, Volume and Issue: 57(8)
Published: April 9, 2024
Abstract Chemotherapy, radiotherapy, and immunotherapy represent key tumour treatment strategies. Notably, immune checkpoint inhibitors (ICIs), particularly anti‐programmed cell death 1 (PD1) ligand (PD‐L1), have shown clinical efficacy in immunotherapy. However, the limited effectiveness of ICIs is evident due to many cancers exhibiting poor responses this treatment. An emerging avenue involves triggering non‐apoptotic regulated (RCD), a significant mechanism driving cancer diverse treatments. Recent research demonstrates that combining RCD inducers with significantly enhances their antitumor across various types. The use anti‐PD‐1/PD‐L1 activates CD8 + T cells, prompting initiation novel forms, such as ferroptosis, pyroptosis, necroptosis. functions mechanisms anti‐PD1/PD‐L1 therapy remain insufficiently explored. This review summarises roles necroptosis It emphasises synergy between nanomaterials PD‐1/PD‐L1 induce different Furthermore, targeting signalling pathways combination therapies holds promise prospective strategy for
Language: Английский
Citations
13
Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)
Published: Jan. 8, 2025
Abstract Background Predictive, preventive, and personalized medicine (PPPM/3PM) is a strategy aimed at improving the prognosis of cancer, programmed cell death (PCD) increasingly recognized as potential target in cancer therapy prognosis. However, PCD-based predictive model for serous ovarian carcinoma (SOC) lacking. In present study, we to establish index (CDI)–based using PCD-related genes. Methods We included 1254 genes from 12 PCD patterns our analysis. Differentially expressed (DEGs) Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) were screened. Subsequently, 14 PCD-gene-based CDI model. Genomics, single-cell transcriptomes, bulk spatial clinical information TCGA-OV, GSE26193, GSE63885, GSE140082 collected analyzed verify prediction Results The was an independent prognostic risk factor patients with SOC. Patients SOC high had lower survival rates poorer prognoses than those low CDI. Specific parameters combined nomogram that accurately assessed patient survival. used PCD-genes observe differences between groups. results showed immunosuppression hardly benefited immunotherapy; therefore, trametinib_1372 BMS-754807 may be therapeutic agents these patients. Conclusions CDI-based model, which established genes, predicted tumor microenvironment, immunotherapy response, drug sensitivity Thus this help improve diagnostic efficacy PPPM.
Language: Английский
Citations
1
Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)
Published: April 15, 2023
This study aims to visualize research hotspots and trends of "ferroptosis in cancer", "necroptosis "pyroptosis "cuproptosis cancer" through a bibliometric analysis facilitate understanding future developments basic clinical provide new perspective on cancer treatment. From January 1, 2012 October 31, 2022, the field total 2467 organizations from 79 different countries published 3302 articles. 2274 72 2233 articles " necroptosis cancer". 1366 institutions 58 contributed 1445 publications In cuproptosis number last 10 years is relatively low, with 109 by 116 four countries. Tang Daolin had 66 documents, ranked first, while Dixon SJ most cited author, 3148 times; fields Vandenabeele peter 35 papers Degterev been 995 times, respectively; Kanneganti thirumala-devi 24 papers, highest Shi JJ was author being 508 times. Both Huang Yan Wang Tao three tied for first place Tsvetkov p ranks 107 times "Cell", "Nature", "Science" frequently co-cited journal respectively. Further exploration inhibitors Programmed cell death (PCD) their targeted therapies are potential treatment options cancer, but more direct evidence as well higher level trials remain be explored. clarification mechanisms crosstalk between these PCDs may effective treatments. And role types PCDs, especially novel ones discovered, can expected hot topic quite some time come.
Language: Английский
Citations
19
Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)
Published: July 29, 2023
Abstract Programmed cell death (PCD) plays an important role in many aspects of individual development, maintenance body homeostasis and pathological processes. Ferroptosis is a novel form PCD characterized by the accumulation iron-dependent lipid peroxides resulting lethal damage. It contributes to tumor progression apoptosis-independent manner. In recent years, increasing number non-coding RNAs (ncRNAs) have been demonstrated mediate biological process ferroptosis, hence impacting carcinogenesis, progression, drug resistance, prognosis. However, clear regulatory mechanism for this phenomenon remains poorly understood. Moreover, ferroptosis does not usually exist independently. Its interaction with PCD, like apoptosis, necroptosis, autophagy, pyroptosis, cuproptosis, destroy cells appears exist. Furthermore, ncRNA seems be involved. Here, we review mechanisms which occurs, dissect its relationship other forms death, summarize key roles played ncRNAs, raise relevant questions predict possible barriers application clinic, offering new ideas targeted tumour therapy.
Language: Английский
Citations
18
Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(8), P. 1660 - 1670
Published: Nov. 8, 2023
Central nervous system injuries have a high rate of resulting in disability and mortality; however, at present, effective treatments are lacking. Programmed cell death, which is genetically determined form active ordered death with many types, has recently attracted increasing attention due to its functions determining the fate survival. A growing number studies suggested that programmed involved central plays an important role progression brain damage. In this review, we provide overview injuries, including pathways mitophagy, pyroptosis, ferroptosis, necroptosis, underlying mechanisms by mitophagy regulates necroptosis. We also discuss new direction therapeutic strategies targeting for treatment aim determine connection between identify therapies modulate following injury. conclusion, based on these properties effects, interventions could be developed as potential agents injury patients.
Language: Английский
Citations
18
Cell Cycle, Journal Year: 2023, Volume and Issue: 22(9), P. 1116 - 1126
Published: Feb. 21, 2023
The E3 ubiquitin ligase 3-hydroxy-3-methylglutaryl reductase degradation (HRD1) was found to be a tumor suppressor in diverse types of cancers; we aimed explore its expression pattern and biological function ovarian cancer (OC). HRD1 OC tissues detected using quantitative real-time polymerase chain reaction (qRT-PCR) immunohistochemistry (IHC). overexpression plasmid transfected into cells. Cell proliferation, colony formation, apoptosis were analyzed bromodeoxy uridineassay, formation assay, flow cytometry, respectively. mice models established the effect on vivo. Ferroptosis evaluated by malondialdehyde, reactive oxygen species, intracellular ferrous iron. Expressions offerroptosis-related factors examined qRT-PCR western blot. Erastin Fer-1 were, respectively, employed promote or inhibit ferroptosis Online bioinformatics tool co-immunoprecipitation assay performed predict verify interactive genes cells, Gain-of-function studies carried out determine roles cell apoptosis, vitro. under-expressed tissues. inhibited proliferation vitro suppressed growth promoted lines. interacted with solute carrier family 7 member 11 (SLC7A11) regulated stability ubiquitination OC. SLC7A11 recovered through enhancing degradation.
Language: Английский
Citations
16
BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)
Published: April 23, 2024
Ovarian cancer (OC) is a gynecological malignancy tumor with high recurrence and mortality rates. Programmed cell death (PCD) an essential regulator in metabolism, whose functions are still unknown OC. Therefore, it vital to determine the prognostic value therapy response of PCD-related genes
Language: Английский
Citations
5