Med, Journal Year: 2024, Volume and Issue: 5(7), P. 660 - 688
Published: April 5, 2024
Language: Английский
Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(6), P. 2031 - 2081
Published: Jan. 1, 2023
Bioactive materials are a special class of biomaterials that can react in vivo to induce biological response or regulate functions, thus achieving better curative effect than traditional inert biomaterials. For cancer theranostics, compared with organic polymer nanomaterials, inorganic nanomaterials possess unique physical and chemical properties, have stronger mechanical stability on the basis maintaining certain bioactivity, easy be compounded various carriers (polymer carriers, etc.), so as achieve specific antitumor efficacy. After entering nanoscale, due nano-size effect, high surface area nanostructures, exhibit effects, which significantly influence interaction organisms. Therefore, research applications bioactive theranostics attracted wide attention. In this review, we mainly summarize recent progress also introduce definition, synthesis modification strategies nanomaterials. Thereafter, tumor imaging therapy, including microenvironment (TME) regulation, catalytic gas regulatory cell death immunotherapy, discussed. Finally, biosafety challenges mentioned, their future development opportunities prospected. This review highlights bioapplication
Language: Английский
Citations
125
Exploration, Journal Year: 2023, Volume and Issue: 3(3)
Published: April 25, 2023
The advent of immunotherapy has revolutionized the treating modalities cancer. Cancer vaccine, aiming to harness host immune system induce a tumor-specific killing effect, holds great promises for its broad patient coverage, high safety, and combination potentials. Despite promising, clinical translation cancer vaccines faces obstacles including lack potency, limited options tumor antigens adjuvants, immunosuppressive microenvironment. Biomimetic bioinspired nanotechnology provides new impetus designing concepts vaccines. Through mimicking stealth coating, pathogen recognition pattern, tissue tropism pathogen, other irreplaceable properties from nature, biomimetic could gain functions such as longstanding, targeting, self-adjuvanting, on-demand cargo release. specific behavior endogenous molecules each type living entity (cell or microorganism) offer unique features address needs immunotherapy. In this review, strategies inspired by eukaryotic cells, bacteria, viruses will be overviewed advancing vaccine development. Our insights into future development shared at end expediting translation.
Language: Английский
Citations
79
ACS Nano, Journal Year: 2023, Volume and Issue: 17(4), P. 3225 - 3258
Published: Feb. 6, 2023
The immune checkpoint blockade (ICB) therapy has revolutionized the field of cancer treatment, while low response rates and systemic toxicity limit its clinical outcomes. With rapid advances in nanotechnology materials science, various types biomaterials have been developed to maximize therapeutic efficacy minimizing side effects by increasing tumor antigenicity, reversing immunosuppressive microenvironment, amplifying antitumor response, reducing extratumoral distribution inhibitors as well enhancing their retention within target sites. In this review, we reviewed current design strategies for different augment ICB effectively then discussed present representative biomaterial-assisted modulation targeted delivery boost therapy. Current challenges future development prospects expanding with were also summarized. We anticipate review will be helpful developing emerging promoting application
Language: Английский
Citations
58
Exploration, Journal Year: 2024, Volume and Issue: 4(6)
Published: March 24, 2024
Abstract Photothermal therapy (PTT) has garnered significant attention in recent years, but the standalone application of PTT still faces limitations that hinder its ability to achieve optimal therapeutic outcomes. Nitric oxide (NO), being one most extensively studied gaseous molecules, presents itself as a promising complementary candidate for PTT. In response, various nanosystems have been developed enable simultaneous utilization and NO‐mediated gas (GT), with integration photothermal agents (PTAs) thermally‐sensitive NO donors prevailing approach. This combination seeks leverage synergistic effects GT while mitigating potential risks associated toxicity through use single laser irradiation. Furthermore, additional internal or external stimuli employed trigger release when combined different types PTAs, thereby further enhancing efficacy. comprehensive review aims summarize advancements gas‐assisted cancer treatment. It commences by providing an overview precursors, including those sensitive photothermal, light, ultrasound, reactive oxygen species, glutathione. These precursors are discussed context dual‐modal PTT/GT. Subsequently, incorporation other treatment modalities such chemotherapy (CHT), photodynamic (PDT), alkyl radical therapy, radiation immunotherapy (IT) creation triple‐modal nanoplatforms is presented. The explores tetra‐modal therapies, PTT/GT/CHT/PDT, PTT/GT/CHT/chemodynamic (CDT), PTT/GT/PDT/IT, PTT/GT/starvation (ST)/IT, PTT/GT/Ca 2+ overload/IT, PTT/GT/ferroptosis (FT)/IT, PTT/GT/CDT/IT. Finally, challenges future perspectives concerning these novel paradigms discussed. anticipated serve valuable resource studies focused on development innovative photothermal/NO‐based nanotheranostics.
Language: Английский
Citations
38
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(32)
Published: June 14, 2024
Abstract Nanomedicine on the basis of aggregated‐induced emission (AIE) luminogens with exceptional potency is growing into a sparkling frontier in fluorescence imaging and phototheranostics. Of particular interest biomimetic AIE nanomedicine comprised by biocarrier, which represents win–win integration are recently developed at tremendous pace, mainly benefiting from intrinsic advantages including enhanced biocompatibility, prolonged circulation time, specific targeting ability, immune activation, supremely extraordinary phototheranostic outputs. In view inexhaustible vigorous vitality field, this review provides an integrated picture involving basic concepts, significant breakthroughs, recent trends. addition, based current achievements, some critical challenges perspectives also discussed.
Language: Английский
Citations
23
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 209, P. 115304 - 115304
Published: April 9, 2024
Language: Английский
Citations
20
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(12)
Published: Feb. 2, 2024
Abstract Due to the presence of natural neoantigens, autologous tumor cells hold great promise as personalized therapeutic vaccines. Yet cell vaccines require multi‐step production that frequently leads loss immunoreactive antigens, causing insufficient immune activation and significantly hampering their clinical applications. Herein, we introduce a novel whole‐cell cancer vaccine by cloaking with lipopolysaccharide‐decorated manganese(II)‐phenolic networks (MnTA nanocloaks) evoke tumor‐specific response for highly efficacious synergistic immunotherapy. The polyphenols coordinate Mn 2+ immediately adhere surface individual cells, thereby forming nanocloak encapsulating neoantigens. Subsequent decoration lipopolysaccharide induces internalization dendritic where ions are released in cytosol, further facilitating stimulator interferon genes (STING) pathway. Highly effective suppression was observed combining nanocloaked treatment anti‐programmed death ligand 1 (anti‐PD‐L1) antibodies‐mediated checkpoint blockade therapy. Our work demonstrates universal yet simple strategy engineer cell‐based nanobiohybrid system enhanced
Language: Английский
Citations
19
ACS Nano, Journal Year: 2024, Volume and Issue: 18(8), P. 6702 - 6717
Published: Feb. 15, 2024
Tumor cell-derived cancer nanovaccines introduce tumor components as functional units that endow the nanovaccine systems with some advantages, especially providing all potential antigens. However, cumbersome assembly steps, risks of exogenous adjuvants, well insufficient lymph node (LN) targeting and dendritic cell (DC) internalization limit efficacy clinical translation existing nanovaccines. Herein, we introduced an endoplasmic reticulum (ER) stress inducer α-mangostin (αM) into cells through poly(d, l-lactide-co-glycolide) nanoparticles harvested biologically self-assembled (αM-Exos) based on biological process exocytosing tumor-derived exosomes (TEXs). Besides presenting multiple antigens, αM-Exos inherited abundant 70 kDa heat shock proteins (Hsp70s) upregulated by ER stress, which can not only act endogenous adjuvants but also improve LN DC internalization. Following subcutaneous injection, efficiently migrated to LNs was expeditiously endocytosed DCs, delivering antigens DCs synchronously, then powerfully triggered antitumor immune responses established long-term memory. Our study exhibited all-in-one platform, fully featured assembled this platform are promising for desirable immunotherapy.
Language: Английский
Citations
16
Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 185, P. 114308 - 114308
Published: April 23, 2022
Language: Английский
Citations
50
Bioactive Materials, Journal Year: 2022, Volume and Issue: 22, P. 491 - 517
Published: Oct. 26, 2022
Tumor vaccination is a promising approach for tumor immunotherapy because it presents high specificity and few side effects. However, vaccines that contain only single antigen can allow immune system evasion by variants. antigens are complex heterogeneous, identifying uniformly expressed cells challenging. Whole produce comprehensive trigger extensive tumor-specific responses. Therefore, an ideal source of vaccines. A better understanding cell-derived their characteristics, along with the development new technologies delivery, help improve vaccine design. In this review, we summarize recent advances in cancer highlight different types engineered approaches, mechanisms, administration methods, future perspectives. We discuss vaccines, including whole cell components, extracellular vesicles, membrane-encapsulated nanoparticles. multiple induce potent they should be to overcome limitations such as insufficient immunogenicity weak targeting. The genetic chemical engineering greatly enhance targeting, intelligence, functionality, thereby realizing stronger Further materials science, biomedicine, oncology facilitate clinical translation
Language: Английский
Citations
47