Mitochondrial-targeted and ROS-responsive nanocarrier via nose-to-brain pathway for ischemic stroke treatment

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(12), P. 5107 - 5120

Published: June 20, 2023

Oxidative stress injury and mitochondrial dysfunction are major obstacles to neurological functional recovery after ischemic stroke. The development of new approaches simultaneously diminish oxidative resist is urgently needed. Inspired by the overproduced reactive oxygen species (ROS) at neuron mitochondria, multifunctional nanoparticles with ROS-responsiveness mitochondrial-targeted (SPNPs) were engineered, achieving specific targeting delivery controllable drug release penumbra. Due nose-to-brain pathway, SPNPs which encapsulated in a thermo-sensitive gel intranasal administration directly delivered penumbra bypassing blood‒brain barrier (BBB) enhancing efficiency. potential for stroke treatment was systematically evaluated

Language: Английский

---

Puerarin: a potential natural neuroprotective agent for neurological disorders

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114581 - 114581

Published: March 24, 2023

Puerarin is an isoflavone compound derived from Pueraria lobata in traditional Chinese medicine. Accumulating evidence has indicated that puerarin demonstrates multiple pharmacological effects and exhibits treatment potential for various neurological disorders. Based on the latest research progress as a neuroprotective agent, its activity, molecular mechanism, therapeutic application were systematically reviewed with emphasis pre-clinical studies. The related information was extracted compiled major scientific databases, including PubMed, ScienceDirect, SpringerLink, National Knowledge Infrastructure, using 'Puerarin', 'Neuroprotection', 'Apoptosis', 'Autophagy', 'Antioxidant', 'Mitochondria', 'Anti-inflammation' keywords. This review complied Preferred Reporting Items Systematic Reviews criteria. Forty-three articles met established inclusion exclusion shown against variety of disorders, ischemic cerebrovascular disease, subarachnoid hemorrhage, epilepsy, cognitive traumatic brain injury, Parkinson's Alzheimer's anxiety, depression, diabetic neuropathy, neuroblastoma/glioblastoma. anti-apoptosis, proinflammatory mediator inhibitory, autophagy regulatory, anti-oxidative stress, mitochondria protection, Ca2+ influx anti-neurodegenerative activities. exerts noticeable models disorders vivo (animal). will contribute to development novel clinical drug candidate However, well-designed, high-quality, large-scale, multicenter randomized studies are needed determine safety utility patients

Language: Английский

---

An overview of in vitro 3D models of the blood-brain barrier as a tool to predict the in vivo permeability of nanomedicines

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 196, P. 114816 - 114816

Published: March 30, 2023

The blood-brain barrier (BBB) prevents efficient drug delivery to the central nervous system. As a result, brain diseases remain one of greatest unmet medical needs. Understanding tridimensional structure BBB helps gain insight into pathology and contributes development novel therapies for diseases. Therefore, 3D models with an ever-growing sophisticated complexity are being developed closely mimic human neurovascular unit. Among these models, hydrogel-, spheroid- organoid-based static have been developed, so microfluidic-based BBB-on-a-chip models. different preclinical BBB, both in health disease, here reviewed, from their application permeability testing nanomedicines across discussing advantages disadvantages each model. validation data vivo is also discussed those cases where provided.

Language: Английский

---

Intranasal drug delivery: The interaction between nanoparticles and the nose-to-brain pathway

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 207, P. 115196 - 115196

Published: Feb. 7, 2024

Language: Английский

---

Lipid-based nanoparticles to address the limitations of GBM therapy by overcoming the blood-brain barrier, targeting glioblastoma stem cells, and counteracting the immunosuppressive tumor microenvironment

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 171, P. 116113 - 116113

Published: Jan. 5, 2024

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor, characterized by high heterogeneity, strong invasiveness, poor prognosis, and a low survival rate. A broad range of nanoparticles have been recently developed as drug delivery systems for GBM therapy owing to their inherent size effect ability cross blood-brain barrier (BBB). Lipid-based (LBNPs), such liposomes, solid lipid NPs (SLNs), nano-structured carriers (NLCs), emerged promising system treatment because unique size, surface modification possibilities, proven bio-safety. In this review, main challenges current clinical strategies on how novel LBNPs overcome them were explored. The application progress LBNP-based in chemotherapy, immunotherapy, gene recent years systematically reviewed, prospect was discussed.

Language: Английский

---

Recent Advances in Intranasal Administration for Brain-Targeting Delivery: A Comprehensive Review of Lipid-Based Nanoparticles and Stimuli-Responsive Gel Formulations

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 1767 - 1807

Published: Feb. 1, 2024

Abstract: Addressing disorders related to the central nervous system (CNS) remains a complex challenge because of presence blood-brain barrier (BBB), which restricts entry external substances into brain tissue. Consequently, finding ways overcome limited therapeutic effect imposed by BBB has become goal in advancing delivery systems targeted brain. In this context, intranasal route emerged as promising solution for delivering treatments directly from nose through olfactory and trigeminal nerve pathways thus, bypassing BBB. The use lipid-based nanoparticles, including nano/microemulsions, liposomes, solid lipid nanostructured carriers, shown promise enhancing efficiency nose-to-brain delivery. These nanoparticles facilitate drug absorption nasal membrane. Additionally, situ gel (ISG) gained attention owing its ability extend retention time administered formulations within cavity. When combined with ISG creates synergistic effect, further overall effectiveness brain-targeted strategies. This comprehensive review provides thorough investigation administration. It delves strengths limitations specific considering anatomical complexities influential factors that play role during dosing. Furthermore, study introduces strategic approaches incorporating framework applications. Finally, recent information on approved products clinical trial status administration, along inclusion quality-by-design–related insights. Keywords: system, based nanoparticle, gel,

Language: Английский

---

Blood–Brain Barrier-Targeting Nanoparticles: Biomaterial Properties and Biomedical Applications in Translational Neuroscience

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(5), P. 612 - 612

Published: May 10, 2024

Overcoming the blood–brain barrier (BBB) remains a significant hurdle in effective drug delivery to brain. While BBB serves as crucial protective barrier, it poses challenges delivering therapeutic agents their intended targets within brain parenchyma. To enhance for treatment of neurological diseases, several technologies circumvent have been developed last few years. Among them, nanoparticles (NPs) are one most versatile and promising tools. Here, we summarize characteristics NPs that facilitate penetration, including size, shape, chemical composition, surface charge, importantly, conjugation with various biological or synthetic molecules such glucose, transferrin, insulin, polyethylene glycol, peptides, aptamers. Additionally, discuss coating surfactants. A comprehensive overview common vitro vivo models NP penetration studies is also provided. The discussion extends discussing impairment under pathological conditions leveraging alterations delivery. Emphasizing need future uncover inherent properties NPs, review advocates role beyond systems calls efforts translating clinic therapeutics. Overall, stand out highly strategy precise targeting disorders.

Language: Английский

---

The blood–brain barriers: novel nanocarriers for central nervous system diseases

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 26, 2025

Abstract The central nervous system (CNS) diseases are major contributors to death and disability worldwide. However, the blood–brain barrier (BBB) often prevents drugs intended for CNS from effectively crossing into brain parenchyma deliver their therapeutic effects. is a semi-permeable with high selectivity. BBB primarily manages transport of substances between blood CNS. To enhance drug delivery disease treatment, various brain-based strategies overcoming have been developed. Among them, nanoparticles (NPs) emphasized due multiple excellent properties. This review starts an overview BBB’s anatomical structure physiological roles, then explores mechanisms, both endogenous exogenous, that facilitate NP passage across BBB. text also delves how nanoparticles' shape, charge, size, surface ligands affect ability cross offers different nanoparticle classifications. concludes examination current challenges in utilizing nanomaterials discusses corresponding directions solutions. aims propose innovative diagnostic approaches design more effective Graphical abstract

Language: Английский

---

Lipid Nanocarriers as Precision Delivery Systems for Brain Tumors

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Brain tumors, particularly glioblastomas, represent the most complicated cancers to treat and manage due their highly invasive nature protective barriers of brain, including blood-brain barrier (BBB). The efficacy currently available treatments, viz., radiotherapy, chemotherapy, immunotherapy, are frequently limited by major side effects, drug resistance, restricted penetration into brain. Lipid nanoparticles (LNPs) have emerged as a promising targeted delivery system for brain tumors. nanocarriers gained tremendous attention tumor therapeutics multiple encapsulation abilities, controlled release, better biocompatibility, ability cross BBB. Herein, detailed analysis design, mechanisms, therapeutic benefits LNPs in treatment is discussed. Moreover, we also discuss safety issues clinical developments current future challenges. Further, focused on transformation therapy eliminating effects engineering overcome related biological barriers, which provide personalized, affordable, low-risk options.

Language: Английский

---

Customizing delivery nano-vehicles for precise brain tumor therapy

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Jan. 28, 2023

Abstract Although some tumor has become a curable disease for many patients, involvement of the central nervous system (CNS) is still major concern. The blood–brain barrier (BBB), special structure in CNS, protects brain from bloodborne pathogens via its excellent properties and hinders new drug development tumor. Recent breakthroughs nanotechnology have resulted various nanovehicless (NPs) as carriers to cross BBB by different strategys. Here, complex compositions characteristics causes formation are elucidated exhaustively. Additionally, versatile nanovehicles with their recent applications pathways on delivery strategies overcome obstacle anti-brain briefly discussed. Customizing nanoparticles treatments proposed improve efficacy gut brain. This review provides broad perspective customizing nano-vehicles facilitate distribution across pave way creation innovative nanotechnology-based nanomaterials treatments.

Language: Английский

---