Nano Research, Journal Year: 2023, Volume and Issue: 17(2), P. 462 - 475
Published: July 1, 2023
Language: Английский
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 375, P. 346 - 365
Published: Sept. 18, 2024
Language: Английский
Citations
9
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101457 - 101457
Published: Jan. 5, 2025
Central nervous system (CNS) diseases are a major cause of disability and death worldwide. Due to the blood-brain barrier (BBB), drug delivery for CNS is extremely challenging. Nano-delivery systems can overcome limitations BBB deliver drugs CNS, improve ability target brain provide potential therapeutic methods diseases. At same time, choice different (bypassing or crossing BBB) further optimize effect nano-drug system. This article reviews nano-delivery way enters brain. Different kinds nanoparticles were discussed in depth.
Language: Английский
Citations
1
Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100556 - 100556
Published: Jan. 20, 2023
Biomaterials and pertaining formulations have been very successful in various diagnostic therapeutic applications because of its ability to overcome pharmacological limitations. Some them gained significant focus the recent decade for their theranostic properties. Exosomes can be grouped as biomaterials, since they consist biological micro/macromolecules possess all properties a stable biomaterial with size nano range. Significant research has gone into isolation exploitation exosomes potential agent. However, limitations terms yield, efficacy, target specificity are continuously being addressed. On other hand, several nano/microformulations responsive physical or chemical alterations were successfully stimulated by tweaking characteristics surrounding environment in. termed photodynamic, sonodynamic thermodynamic systems. In this regard, ultrasound acoustic systems extensively studied towards altering which applied on. review, we detailed about separately, consisting conventional applications, drawbacks, developments addressing challenges. The information categorized sections that provide complete overview strategies diseases. Then ultrasound-based disease diagnosis therapy elaborated, special interest use enhancing efficacy nanomedicines nanodrug delivery systems, Finally, discussed exosomes, could future theranostics.
Language: Английский
Citations
22
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 205, P. 115176 - 115176
Published: Jan. 9, 2024
Language: Английский
Citations
7
PLoS Medicine, Journal Year: 2024, Volume and Issue: 21(5), P. e1004408 - e1004408
Published: May 17, 2024
Preclinical studies have demonstrated that tumour cell death can be enhanced 10- to 40-fold when radiotherapy is combined with focussed ultrasound-stimulated microbubble (FUS-MB) treatment. The acoustic exposure of microbubbles (intravascular gas microspheres) within the target volume causes bubble cavitation, which induces perturbation vasculature and activates endothelial apoptotic pathways responsible for ablative effect stereotactic body radiotherapy. Subsequent irradiation a microbubble-sensitised rapid increased death. study here presents mature safety efficacy outcomes magnetic resonance (MR)-guided FUS-MB (MRgFUS-MB) treatment, radioenhancement therapy breast cancer.
Language: Английский
Citations
7
Ultrasonics Sonochemistry, Journal Year: 2024, Volume and Issue: 103, P. 106798 - 106798
Published: Feb. 1, 2024
Non-invasive and high spatiotemporal resolution mythologies for the diagnosis treatment of disease in clinical medicine promote development modern medicine. Ultrasound (US) technology provides a non-invasive, real-time, cost-effective imaging modality, which plays significant role chemical synthesis translation, especially vivo cancer therapy. On one hand, US is usually accompanied by cavitation, leading to temperature pressure, so-called "hot spot", playing sonochemical-based colloidal synthesis. Compared with classical nucleation synthetic method, sonochemical strategy presents efficiency fabrication nanocrystals due its fast growth procedure. other attractive medical treatment, applications increasing novel contrast agents, such as micro nano bubbles, are widely used neuromodulation, can breach blood–brain barrier temporarily safely, opening new door neuromodulation In terms sonodynamic therapy US-assisted synergetic show great effects against immunotherapy present unparalleled potentiality compared therapies. Further ultrasound revolutionize both translation improving efficiency, precision, accessibility while reducing environmental impact enhancing patient care. this paper, we review biological applications, next generation technology-assisted applications.
Language: Английский
Citations
6
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 209, P. 115323 - 115323
Published: April 21, 2024
Language: Английский
Citations
6
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(7), P. 849 - 849
Published: June 22, 2024
The state of well-being and health our body is regulated by the fine osmotic biochemical balance established between cells different tissues, organs, systems. Specific districts human are defined, kept in correct functioning, and, therefore, protected from exogenous or endogenous insults both mechanical, physical, biological nature presence barrier In addition to placental barrier, which even acts as a linker two organisms, mother fetus, all barriers, including blood-brain (BBB), blood-retinal blood-nerve blood-lymph blood-cerebrospinal fluid operate maintain physiological homeostasis within tissues organs. From pharmaceutical point view, most challenging undoubtedly BBB, since its notably complicates treatment brain disorders. BBB action can impair delivery chemical drugs biopharmaceuticals into brain, reducing their therapeutic efficacy and/or increasing unwanted bioaccumulation surrounding healthy tissues. Recent nanotechnological innovation provides advanced biomaterials ad hoc customized engineering functionalization methods able assist brain-targeted drug delivery. this context, lipid nanocarriers, synthetic (liposomes, solid nanoparticles, nanoemulsions, nanostructured carriers, niosomes, proniosomes, cubosomes) cell-derived ones (extracellular vesicles cell membrane-derived nanocarriers), considered one successful systems due reasonable biocompatibility ability cross BBB. This review aims provide complete up-to-date view on varied whether FDA-approved, involved clinical trials, used vitro vivo studies, for inflammatory, cancerous, infectious diseases.
Language: Английский
Citations
6
Small, Journal Year: 2024, Volume and Issue: 21(1)
Published: Oct. 23, 2024
Abstract Over the past decade, precision medicine has garnered increasing attention, making significant strides in discovering new therapeutic drugs and mechanisms, resulting notable achievements symptom alleviation, pain reduction, extended survival rates. However, limited target specificity of primary inter‐individual differences have often necessitated high‐dosage strategies, leading to challenges such as restricted deep tissue penetration rates systemic side effects. Material science advancements present a promising avenue for these issues. By leveraging distinct internal features diseased regions application specific external stimuli, responsive materials can be tailored achieve targeted delivery, controllable release, biochemical reactions. This review aims highlight latest stimuli‐responsive their potential medicine. Initially, we introduce disease‐related stimuli capable elucidating reaction principles functional groups. Subsequently, provide detailed analysis representative pre‐clinical across various clinical applications, including enhancements treatment cancers, injury diseases, inflammatory infection high‐throughput microfluidic biosensors. Finally, discuss some challenges, off‐target effects, long‐term impacts nano‐materials, ethical concerns, offer insights into future perspectives materials.
Language: Английский
Citations
6
International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 3745 - 3760
Published: July 1, 2023
The tight structure of the blood-brain barrier severely limits level drug therapy for central nervous system disorders. In this study, a novel composite delivery combining nanocarrier and microneedle technology was prepared to explore possibility transdermal drugs work in brain.Nanoparticle solutions containing paroxetine rhodamine-B were using PLGA as carrier by emulsification-solvent volatilization method. Then, they mixed with hyaluronic acid nanoparticulate-based (Rh-NPs-DMNs) multi-step decompression-free diffusion particle size, zeta potential, micromorphology nano solution measured; appearance, mechanical strength, dissolution properties, puncture effect Rh-NPs-DMNs evaluated; also, it evaluated vivo live imaging properties vitro skin layer transport distribution properties.The mean size Rh-NPs 96.25 ± 2.26 nm; potential 15.89 1.97 mV; PDI 0.120 0.079. had high needle content 96.11 1.27% tip height 651.23 1.28 μm, excellent (fracture force 299.78 1.74 N). H&E tissue staining showed that produced micron-sized pores approximately 550 μm deep immediately after administration, allowing efficient circulation drug; results Rh-B NPs DMNs faster rate than DMNs, strong fluorescent signals both brain (P<0.01) hippocampus (P<0.05) 48 h administration.Nanoparticles can prolong blood time intracerebral retention have certain brain-targeting due their physical properties. use combined nanocarriers provides new ideas systems treatment neurological diseases.
Language: Английский
Citations
13