Key Transdermal Patch Using Cannabidiol-Loaded Nanocarriers with Better Pharmacokinetics in vivo

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 4321 - 4337

Published: May 1, 2024

Cannabidiol (CBD) is a promising therapeutic drug with low addictive potential and favorable safety profile. However, CBD did face certain challenges, including poor solubility in water oral bioavailability. To harness the of by combining it transdermal delivery system (TDDS). This innovative approach sought to develop patch dosage form micellar vesicular nanocarriers enhance bioavailability CBD, leading improved outcomes.

Language: Английский

---

Nanosuspension-Loaded Dissolving Microneedle Patches for Enhanced Transdermal Delivery of a Highly Lipophilic Cannabidiol

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 4061 - 4079

Published: May 1, 2024

Purpose: Transdermal Drug Delivery System (TDDS) offers a promising alternative for delivering poorly soluble drugs, challenged by the stratum corneum's barrier effect, which restricts pool of drug candidates suitable TDDS. This study aims to establish delivery platform specifically highly lipophilic drugs requiring high doses (log P > 5, dose 10 mg/kg/d), improve their intradermal and enhance solubility. Methods: Cannabidiol (CBD, log = 5.91) served as model drug. A CBD nanosuspension (CBD-NS) was prepared using bottom-up method. The particle size, polydispersity index (PDI), zeta potential, concentration CBD-NS were characterized. Subsequently, incorporated into dissolving microneedles (DMNs) through one-step manufacturing process. dissolution abilities, physicochemical properties, mechanical strength, insertion depth, release behavior DMNs evaluated. Sprague-Dawley (SD) rats utilized assess efficacy DMN patch in treating knee synovitis analyze its skin permeation kinetics pharmacokinetic performance. Results: CBD-NS, stabilized with Tween 80, exhibited size 166.83 ± 3.33 nm, PDI 0.21 0.07, 46.11 0.52 mg/mL. loaded demonstrated favorable properties. It effectively increased skin, extended action's duration vivo, enhanced bioavailability. superior therapeutic safety rat synovitis, significantly inhibiting TNF-α IL-1β compared methotrexate subcutaneous injection Conclusion: NS technology enhances solubility CBD, while facilitates penetration, extends action improves Furthermore, has shown outcomes synovitis. innovative system is expected offer more efficient solution administration akin thereby facilitating high-dose administration. Keywords: nanosuspension, microneedle, cannabidiol,

Language: Английский

---

A review on brain-targeting nano-based drug delivery

Chinese Science Bulletin (Chinese Version), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

---

Nanoengineered Microneedles: A Versatile Targeted Delivery System for Theragnostic Applications

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Microneedles (MNs) have been used as active drug delivery carriers by precisely delivering drugs to the targeted site along with minimal tissue destruction. Earlier, MNs were for of transdermal site; now they are solid tumor site, mucosal, ophthalmic, and other organ site-specific delivery. considered a boon trans-barrier because routes, such systemic parenteral, face challenges limiting optimum amount reaching skin or barrier-containing organs. Hence, MN-mediated enhances permeation improves brain ciliary nasal clearance crossing barrier. The current book chapter mainly focuses on recent advancements in area MN-based into various parts body, their theragnostic applications, organs containing barriers, encounters has discussed. Also, comprehensive overview MN types, fabrication polymers, mechanisms release, effectiveness, advantages over conventional systems summarized.

Language: Английский

---

Nano-formulated curcumin uptake and biodistribution in the fetal growth restricted newborn piglet brain

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Language: Английский

---

Microneedle-aided nanotherapeutics delivery and nanosensor intervention in advanced tissue regeneration

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 3, 2025

Language: Английский

---

Research Progress of Extracellular Vesicles-Loaded Microneedle Technology

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 326 - 326

Published: Feb. 26, 2024

Microneedles (MNs), renowned for their painless and minimally invasive qualities, exhibit significant potential facilitating effective drug delivery, vaccination, targeted sample extraction. Extracellular vesicles (EVs), serving as cargo MNs, are naturally occurring nanovesicles secreted by cells characterized novel biomarkers, low immunogenicity, cell-source-specific traits. MNs prove instrumental in extracting EVs from the fluid, thereby a promising diagnostic prognostic tool. To harness therapeutic of tissue repair, with sustained delivery leverage micron-sized channels to enhance site concentration, demonstrating efficacy treating various diseases, such Achillea tendinopathy, hair loss, spinal cord injury, diabetic ulcers. EV-loaded emerge platform repair applications skin, cardiac, tendon, hair, tissues. This review commences an overview subsequently delving into role MNs. The paper then synthesizes latest advancements use regenerative extending research progress disease diagnosis evaluations. It aims offer valuable insights forecast future trajectories hope inspiring innovative ideas among researchers this field.

Language: Английский

---

Mechanical strength affecting the penetration in microneedles and PLGA nanoparticle-assisted drug delivery: Importance of preparation and formulation

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116339 - 116339

Published: Feb. 29, 2024

Microneedles (MNs) prepared from polymeric materials are painless and minimally invasive, safe efficient, but they hindered by low mechanical strength single diverse drug release pattern. Due to the distinctive dimensions of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs), integration nano-technology with microneedles can effectively improve penetration delivery efficiency through stratum corneum. We herein designed a simple paroxetine (PAX)-loaded PLGA nanoparticles-integrated dissolving system (PAX-NPs-DMNs), aiming bioavailability PAX synergistic permeation-enhancing effect (DMNs) NPs. PAX-NPs-DMNs had complete tips molding rate (Neff) (94.06 ± 2.16) %, 15×15 quadrangular-conical microneedle array an overall fracture force 301.10 N, which were improved nearly 0.50 times compared blank (HA-DMNs) (PAX-DMNs). could extend duration 1 h 24 cumulative permeability per unit area (Qn) was 47.66 7.37 higher than PAX-DMNs groups. be rapidly dissolved within 10 min without hindering skin healing or causing adverse reactions. This study confirmed that DMNs, easily penetrate provide sustained effects, thus offering more convenient effective method for central nervous diseases.

Language: Английский

---

Application of hydrogel microneedles in the oral cavity

Biopolymers, Journal Year: 2024, Volume and Issue: 115(3)

Published: March 20, 2024

Abstract Microneedles are a transdermal drug delivery system in which the needle punctures epithelium to deliver directly deep tissues, thus avoiding influence of first‐pass effect gastrointestinal tract and minimizing likelihood pain induction. Hydrogel microneedles prepared from hydrogels that have good biocompatibility, controllable mechanical properties, release can be modified achieve environmental control vivo. The large epithelial tissue oral cavity is an ideal site for via microneedles. overcome mucosal hindrances delivering drugs tissues; this prevents humidity highly dynamic environment influencing efficacy enables them obtain better therapeutic effects. This article analyzes materials advantages common hydrogel reviews application cavity.

Language: Английский

---

Investigating Laser Ablation Process Parameters for the Fabrication of Customized Microneedle Arrays for Therapeutic Applications

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(7), P. 885 - 885

Published: June 30, 2024

Microneedles are an innovation in the field of medicine that have potential to revolutionize drug delivery, diagnostics, and cosmetic treatments. This provides a minimally invasive means deliver drugs, vaccines, other therapeutic substances into skin. research investigates design manufacture customized microneedle arrays using laser ablation. Laser ablation was performed ytterbium on polymethyl methacrylate (PMMA) substrate create mold for casting polydimethylsiloxane (PDMS) microneedles. An experimental conducted evaluate effect process parameters including pulse power, width, repetition, interval between pulses, profile desired geometry The analysis variance (ANOVA) model showed lasing interval, width had highest influence output metrics (diameter height) microneedle. dimensions increase with higher vice versa interval. A response surface indicated (independent variables) significantly affect diameter height (dependent variable). predictive generated predict topology aspect ratio varying from 0.8 1.5 based variation critical input parameters. lays foundation fabrication microneedles variations specific applications dermal sensors, vaccine delivery.

Language: Английский

---