Solid lipid-based nanobiosystems as theranostics

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 327 - 348

Published: Jan. 1, 2025

Language: Английский

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Construction of glutathione-responsive paclitaxel prodrug nanoparticles for image-guided targeted delivery and breast cancer therapy

RSC Advances, Journal Year: 2024, Volume and Issue: 14(18), P. 12796 - 12806

Published: Jan. 1, 2024

Paclitaxel (PTX) remains an essential drug in the treatment of breast cancer. To improve metabolic stability and real-time monitoring location, we develop a visualized nano-prodrug. Novel hyaluronic acid (HA)-coated glutathione (GSH)-sensitive chitosan (CS)-based nano-prodrug (HA/TPE-CS-SS-PTX NPs) with aggregation-induced emission effects (AIE) were accomplished. The prodrug NPs (drug loading 29.32%, particle size 105 nm, regular sphericity) exhibit excellent fluorescence stability. could target tumor cells high expression CD44 decompose presence concentrations glutathione.

Language: Английский

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Gold Nanostars and Nanourchins for Enhanced Photothermal Therapy, Bioimaging, and Theranostics

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Photothermal therapy (PTT), a recently emerging method for eradicating tumors, utilizes hyperthermia induced by photo-absorbing materials to generate heat within cancer cells. Gold nanoparticles (AuNPs) have gained reliability

Language: Английский

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Updates and current states on liposomal vehicles for tumor targeting: precision therapy in the spotlight

Cancer Nanotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 10, 2025

Language: Английский

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Ultrasound Visualization of Spatiotemporal Autophagy-Regulated Nanodroplets for Amplifying ICB in Melanoma via Remodeling Tumor Inflammatory Microenvironment

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Immune checkpoint blockade (ICB) therapy, represented by anti-PD-1/PD-L1 antibodies, is confronted with difficulties of unsatisfied response rates owing to the prevalence "cold" immune tumor microenvironment (TME) in most cancers. Blocking cytoprotective autophagy has emerged as a potential strategy remodel inflammatory TME. Nevertheless, dual roles progression, coupled poor pharmacokinetic properties small-molecule inhibitors, significantly restrict clinical applications. To address these challenges, low-intensity focused ultrasound (LIFU) responsive phase-change nanodroplet delivery platform (SP@Lip-PEG) elaborately developed deliver specific inhibitor SAR405 for activating typical tumor-resident cells. The PEG-modified nanodroplets effectively accumulate into site. Upon LIFU activation, SP@Lip-PEG transforms microbubbles through acoustic droplet vaporization (ADV) effects, enabling controlled release under imaging guidance. released triggered upregulation proinflammatory factors CCL5 and CXCL10 manipulation, creating an TME facilitate recruitment natural killer (NK) cells CD8+ T cells, along promoting dendritic cell (DC) maturation synergistically enhancing ICB efficacy. With high specificity controllable therapeutic process irradiation, this noninvasive, efficient, cost-effective drug vector opened new horizons conquering dilemma rescuing rates.

Language: Английский

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Intranasal administration nanosystems for brain-targeted drug delivery

Nano Research, Journal Year: 2023, Volume and Issue: 16(12), P. 13077 - 13099

Published: Oct. 12, 2023

Language: Английский

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Delivery of miR‐3529‐3p using MnO₂‐SiO₂‐APTES nanoparticles combined with phototherapy suppresses lung adenocarcinoma progression by targeting HIGD1A

Thoracic Cancer, Journal Year: 2023, Volume and Issue: 14(10), P. 913 - 928

Published: Feb. 20, 2023

The present study aimed to investigate the function of miR-3529-3p in lung adenocarcinoma and MnO2 -SiO2 -APTES (MSA) as a promising multifunctional delivery agent for therapy.Expression levels were evaluated carcinoma cells tissues by qRT-PCR. effects on apoptosis, proliferation, metastasis neovascularization assessed CCK-8, FACS, transwell wound healing assays, tube formation xenografts experiments. Luciferase reporter western blot, qRT-PCR mitochondrial complex assay used determine targeting relationship between hypoxia-inducible gene domain family member 1A (HIGD1A). MSA was fabricated using nanoflowers, its heating curves, temperature IC50, efficiency examined. hypoxia reactive oxygen species (ROS) production investigated nitro reductase probing, DCFH-DA staining FACS.MiR-3529-3p expression reduced cells. Transfection could promote apoptosis suppress cell migration angiogenesis. As target miR-3529-3p, HIGD1A downregulated, through which disrupt activities complexes III IV respiratory chain. nanoparticle not only efficiently deliver into cells, but also enhance antitumor miR-3529-3p. underlying mechanism may be that alleviates has synergistic cellular ROS promotion with miR-3529-3p.Our results establish antioncogenic role demonstrate delivered enhanced tumor suppressive effects, probably elevating thermogenesis.

Language: Английский

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Enhancing hair regeneration: Recent progress in tailoring nano-structured lipid carriers through surface modification strategies

ADMET & DMPK, Journal Year: 2024, Volume and Issue: 12(3), P. 431 - 462

Published: July 20, 2024

Background and purpose: Hair loss is a prevalent problem affecting millions of people worldwide, necessitating innovative efficient regrowth approaches. Nanostructured lipid carriers (NLCs) have become hopeful option for transporting bioactive substances to hair follicles because their compatibility with the body capability improve drug absorption. Review approach: Recently, surface modification techniques been used enhance regeneration by improving customization NLCs. These involve applying polymers, incorporating targeting molecules, modifying charge. Key results: The conversation focuses on how these stability, body, precise delivery within Moreover, it explains surface-modified NLCs can bioavailability growth-promoting agents like minoxidil finasteride. Furthermore, information interact given, uncovering possible uses in treating conditions. Conclusion: This review discusses potential altering customize them enhanced growth. It offers important upcoming studies

Language: Английский

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Tumor-specific theranostics with stimulus-responsive MRI nanoprobes: Current advances and future perspectives

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 527, P. 216402 - 216402

Published: Dec. 25, 2024

Language: Английский

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Controlled assembly of superparamagnetic iron oxide nanoparticle into nanoliposome for Pickering emulsion preparation

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 241, P. 114051 - 114051

Published: June 21, 2024

There has been a surge in effort the development of various solid nanoparticles as Pickering emulsion stabilizers past decades. Regardless, exploration that simultaneously stabilize and deliver bioactive limited. For this, liposomes with amphiphilic nature have introduced but these nano-sized vesicles lack targeting specificity. Therefore this study, superparamagnetic iron oxide (SPION) encapsulated within (MLP) were used to prepare pH magnetic-responsive emulsions. A stable MLP-stabilized formulation was established by varying MLP pH, concentration, oil loading during emulsification process. The primary stabilization mechanism under variation identified be largely associated phosphate group deprotonation. When subjected sequential adjustment imitate gastrointestinal digestion environment, recovery integrity observed changes from acidic alkaline. By incorporating SPION, can guided targeted site influence magnetic field without compromising stability. Overall, results demonstrated potential dual pH- drug delivery carrier ability co-encapsulate hydrophobic hydrophilic bioactive.

Language: Английский

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