Nano Biomaterials for Neurological Theranostics DOI

Muhammad Muhammad,

Shereen M. Elsherbiny

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 211 - 244

Published: Oct. 11, 2024

This chapter delves into the transformative potential of nanotechnology in neurological theranostics, examining current diagnostic challenges and emerging trends nanomedicine. It highlights limitations conventional methods underscores need for innovative solutions. From nanoscale biosensors early disease detection to targeted drug delivery systems overcoming blood-brain barrier, offers novel strategies enhanced patient care. However, addressing validation, standardization, scalability, safety concerns is crucial. By fostering interdisciplinary collaborations, integrating nano biomaterials holds promise personalized neuro-theranostics, improving outcomes individuals with disorders.

Language: Английский

Recent Advances in Nanotherapeutics for Neurological Disorders DOI Creative Commons
Arti Vashist, Pandiaraj Manickam, Andrea Raymond

et al.

ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(7), P. 2614 - 2621

Published: June 27, 2023

Neurological disorders remain a significant health and economic burden worldwide. Addressing the challenges imposed by existing drugs, associated side- effects, immune responses in neurodegenerative diseases is essential for developing better therapies. The activation diseased state has complex treatment protocols results hurdles clinical translation. There an immense need development of multifunctional nanotherapeutics with various properties to address different limitations interactions exhibited therapeutics. Nanotechnology proven its potential improve therapeutic delivery enhance efficacy. Promising advancements have been made nanotherapies that can be combined CRISPR/Cas9 or siRNA targeted approach unique Engineering natural exosomes derived from mesenchymal stem cells (MSCs), dendritic (DCs), macrophages both deliver therapeutics modulate tumors disease (ND) allow personalized approaches. In present review, we summarize overview recent advances addressing neuroimmune ND therapies provide insights into upcoming nanotechnology-based nanocarriers.

Language: Английский

Citations

30

Electrostimulation via a 3D-printed, biomimetic, neurotrophic, electroconductive scaffold for the promotion of axonal regrowth after spinal cord injury DOI Creative Commons
Liam M. Leahy, Ian Woods, Javier Gutierrez Gonzalez

et al.

Materials Today, Journal Year: 2024, Volume and Issue: 79, P. 60 - 72

Published: Aug. 28, 2024

Spinal cord injury (SCI) is a devastating neurotrauma, affecting 250,000 to 500,000 people annually, and typically results in paralysis. Electrostimulation can promote neuronal growth, but the formation of lesion cavity post-SCI inhibits regrowth, limiting its efficacy. Bridging with structured, electroactive substrate direct electrostimulation growing neurites could support drive regrowth through enable functional recovery date, no such platform exists. This study describes development an electroconductive (15 ± 5 S/m), 3D-printed scaffold, comprising polypyrrole/polycaprolactone framework filled biomimetic & neurotrophic extracellular matrix. 3D printing allowed inclusion channels scaffold designed mimic size human corticospinal tracts neurons. Scaffolds exhibited excellent biocompatibility both neurons primary astrocytes maintained electrical biofunctionality when scaled match tracts. When were cultured for 7 days on scaffolds under continuous (200 mV/mm, 12 Hz), significantly longer observed electrically stimulated scaffolds. These demonstrate that applied via anatomically-mimetic, drives neurite outgrowth represents promising approach treatment spinal injury.

Language: Английский

Citations

8

Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions DOI Creative Commons
Hye Kyu Choi,

Meizi Chen,

Li Ling Goldston

et al.

Nano Convergence, Journal Year: 2024, Volume and Issue: 11(1)

Published: May 13, 2024

Abstract Central Nervous System (CNS) disorders represent a profound public health challenge that affects millions of people around the world. Diseases such as Alzheimer’s disease (AD), Parkinson’s (PD), and traumatic brain injury (TBI) exemplify complexities diversities complicate their early detection development effective treatments. Amid these challenges, emergence nanotechnology extracellular vesicles (EVs) signals new dawn for treating diagnosing CNS ailments. EVs are cellularly derived lipid bilayer nanosized particles pivotal in intercellular communication within have potential to revolutionize targeted therapeutic delivery identification novel biomarkers. Integrating with amplifies diagnostic capabilities, opening avenues managing diseases. This review focuses on examining fascinating interplay between theranostics. Through highlighting remarkable advancements unique methodologies, we aim offer valuable perspectives how approaches can bring about revolutionary change management. The objective is harness distinctive attributes forge personalized, efficient interventions disorders, thereby providing beacon hope affected individuals. In short, confluence heralds promising frontier impactful treatments against diseases, which continue pose significant challenges. By focusing personalized powerful methods, might improve quality patients.

Language: Английский

Citations

6

Recent Advances in Nanomaterials for Modulation of Stem Cell Differentiation and Its Therapeutic Applications DOI Creative Commons
Chang‐Dae Kim, Kyeong‐Mo Koo, Hyung Joo Kim

et al.

Biosensors, Journal Year: 2024, Volume and Issue: 14(8), P. 407 - 407

Published: Aug. 22, 2024

Challenges in directed differentiation and survival limit the clinical use of stem cells despite their promising therapeutic potential regenerative medicine. Nanotechnology has emerged as a powerful tool to address these challenges enable precise control over cell fate. In particular, nanomaterials can mimic an extracellular matrix provide specific cues guide proliferation field nanotechnology. For instance, recent studies have demonstrated that nanostructured surfaces scaffolds enhance lineage commitment modulated by intracellular regulation external stimulation, such reactive oxygen species (ROS) scavenging, autophagy, or electrical stimulation. Furthermore, nanoframework-based upconversion nanoparticles be used deliver bioactive molecules, growth factors, genetic materials facilitate tissue regeneration. The increasing nanostructures research led development new approaches. Therefore, this review provides overview advances for modulating differentiation, including metal-, carbon-, peptide-based strategies. addition, we highlight nano-enabled technologies applications therapy focusing on improving efficiency therapeutics. We believe will inspire researchers intensify efforts deepen understanding, thereby accelerating modulation, pharmaceutical industry,

Language: Английский

Citations

6

Development of a highly sensitive CNT-metal graphene hybrid nano-IDA electrochemical biosensor for the diagnosis of Alzheimer's disease DOI
Muhammad Rahman, Bappa Sarkar, Md Tareq Rahman

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

In this work, a novel CNT-metal-porous graphene hybrid nano-interdigitated array electrochemical 8-well biosensor has been developed for the successful early-stage diagnosis of Alzheimer's disease from blood using e-ELISA enzyme by-product PAP.

Language: Английский

Citations

5

Insights into Advances and Applications of Biomaterials for Nerve Tissue Injuries and Neurodegenerative Disorders DOI Creative Commons

Varsha Pai,

Bhisham Narayan Singh, Abhishek Kumar Singh

et al.

Macromolecular Bioscience, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Abstract The incidence of nerve tissue injuries, such as peripheral injury, spinal cord traumatic brain and various neurodegenerative diseases (NDs), is continuously increasing because stress, physical chemical trauma, the aging population worldwide. Restoration damaged nervous system challenging its structural functional complexity limited regenerative ability. Additionally, there no cure available for NDs except medications that provide symptomatic relief. Stem cells offer an alternative approach promoting damage repair, but their efficacy by a compromised survival rate neurogenesis process. To address these challenges, neural engineering has emerged promising strategy in which stem are seeded or encapsulated within suitable biomaterial construct, cell neurogenesis. Numerous biomaterials utilized to create different types constructs this purpose. Researchers trying develop ideal scaffolds combine biomaterials, cells, molecules exactly mimic biological mechanical properties achieve recovery associated with neurological dysfunction. This review focuses on exploring development applications potential use diagnosis, therapy, regeneration, treatment disorders.

Language: Английский

Citations

5

Nanoparticle Strategies for Treating CNS Disorders: A Comprehensive Review of Drug Delivery and Theranostic Applications DOI Open Access
Corneliu Toader, Adrian Dumitru,

Lucian Eva

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13302 - 13302

Published: Dec. 11, 2024

This review aims to address the significant challenges of treating central nervous system (CNS) disorders such as neurodegenerative diseases, strokes, spinal cord injuries, and brain tumors. These are difficult manage due complexity disease mechanisms protective blood–brain barrier (BBB), which restricts drug delivery. Recent advancements in nanoparticle (NP) technologies offer promising solutions, with potential applications delivery, neuroprotection, neuroregeneration. By examining current research, we explore how NPs can cross BBB, deliver medications directly targeted CNS regions, enhance both diagnostics treatment. Key NP strategies, passive targeting, receptor-mediated transport, stimuli-responsive systems, demonstrate encouraging results. Studies show that may improve minimize side effects, increase therapeutic effectiveness models Alzheimer’s, Parkinson’s, stroke, glioblastoma. thus represent a approach for disorder management, combining delivery diagnostic capabilities enable more precise effective treatments could significantly benefit patient outcomes.

Language: Английский

Citations

5

Nanomaterials-Based Exosomes for the Diagnostics and Drug Deliveries of Central Nervous System Diseases DOI

Izzati Haizan,

Dong Hyeok Park,

Min Yu Choi

et al.

BioChip Journal, Journal Year: 2023, Volume and Issue: 17(3), P. 293 - 307

Published: July 4, 2023

Language: Английский

Citations

12

Dual-target magneto-immunoassay with bifunctional nanohybrids for breast cancer exosome detection DOI

Izzati Haizan,

Min Yu Choi,

Dong Hyeok Park

et al.

Talanta, Journal Year: 2025, Volume and Issue: 286, P. 127532 - 127532

Published: Jan. 8, 2025

Language: Английский

Citations

0

Nanoparticle-Based Biomarkers for Neurological Disorders DOI

Neelakanta Sarvashiva Kiran,

Chandrashekar Yashaswini,

Ankita Chatterjee

et al.

Nanotechnology in the life sciences, Journal Year: 2025, Volume and Issue: unknown, P. 183 - 202

Published: Jan. 1, 2025

Language: Английский

Citations

0