Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 211 - 244
Published: Oct. 11, 2024
This
chapter
delves
into
the
transformative
potential
of
nanotechnology
in
neurological
theranostics,
examining
current
diagnostic
challenges
and
emerging
trends
nanomedicine.
It
highlights
limitations
conventional
methods
underscores
need
for
innovative
solutions.
From
nanoscale
biosensors
early
disease
detection
to
targeted
drug
delivery
systems
overcoming
blood-brain
barrier,
offers
novel
strategies
enhanced
patient
care.
However,
addressing
validation,
standardization,
scalability,
safety
concerns
is
crucial.
By
fostering
interdisciplinary
collaborations,
integrating
nano
biomaterials
holds
promise
personalized
neuro-theranostics,
improving
outcomes
individuals
with
disorders.
ACS Applied Bio Materials,
Journal Year:
2023,
Volume and Issue:
6(7), P. 2614 - 2621
Published: June 27, 2023
Neurological
disorders
remain
a
significant
health
and
economic
burden
worldwide.
Addressing
the
challenges
imposed
by
existing
drugs,
associated
side-
effects,
immune
responses
in
neurodegenerative
diseases
is
essential
for
developing
better
therapies.
The
activation
diseased
state
has
complex
treatment
protocols
results
hurdles
clinical
translation.
There
an
immense
need
development
of
multifunctional
nanotherapeutics
with
various
properties
to
address
different
limitations
interactions
exhibited
therapeutics.
Nanotechnology
proven
its
potential
improve
therapeutic
delivery
enhance
efficacy.
Promising
advancements
have
been
made
nanotherapies
that
can
be
combined
CRISPR/Cas9
or
siRNA
targeted
approach
unique
Engineering
natural
exosomes
derived
from
mesenchymal
stem
cells
(MSCs),
dendritic
(DCs),
macrophages
both
deliver
therapeutics
modulate
tumors
disease
(ND)
allow
personalized
approaches.
In
present
review,
we
summarize
overview
recent
advances
addressing
neuroimmune
ND
therapies
provide
insights
into
upcoming
nanotechnology-based
nanocarriers.
Materials Today,
Journal Year:
2024,
Volume and Issue:
79, P. 60 - 72
Published: Aug. 28, 2024
Spinal
cord
injury
(SCI)
is
a
devastating
neurotrauma,
affecting
250,000
to
500,000
people
annually,
and
typically
results
in
paralysis.
Electrostimulation
can
promote
neuronal
growth,
but
the
formation
of
lesion
cavity
post-SCI
inhibits
regrowth,
limiting
its
efficacy.
Bridging
with
structured,
electroactive
substrate
direct
electrostimulation
growing
neurites
could
support
drive
regrowth
through
enable
functional
recovery
date,
no
such
platform
exists.
This
study
describes
development
an
electroconductive
(15
±
5
S/m),
3D-printed
scaffold,
comprising
polypyrrole/polycaprolactone
framework
filled
biomimetic
&
neurotrophic
extracellular
matrix.
3D
printing
allowed
inclusion
channels
scaffold
designed
mimic
size
human
corticospinal
tracts
neurons.
Scaffolds
exhibited
excellent
biocompatibility
both
neurons
primary
astrocytes
maintained
electrical
biofunctionality
when
scaled
match
tracts.
When
were
cultured
for
7
days
on
scaffolds
under
continuous
(200
mV/mm,
12
Hz),
significantly
longer
observed
electrically
stimulated
scaffolds.
These
demonstrate
that
applied
via
anatomically-mimetic,
drives
neurite
outgrowth
represents
promising
approach
treatment
spinal
injury.
Nano Convergence,
Journal Year:
2024,
Volume and Issue:
11(1)
Published: May 13, 2024
Abstract
Central
Nervous
System
(CNS)
disorders
represent
a
profound
public
health
challenge
that
affects
millions
of
people
around
the
world.
Diseases
such
as
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
and
traumatic
brain
injury
(TBI)
exemplify
complexities
diversities
complicate
their
early
detection
development
effective
treatments.
Amid
these
challenges,
emergence
nanotechnology
extracellular
vesicles
(EVs)
signals
new
dawn
for
treating
diagnosing
CNS
ailments.
EVs
are
cellularly
derived
lipid
bilayer
nanosized
particles
pivotal
in
intercellular
communication
within
have
potential
to
revolutionize
targeted
therapeutic
delivery
identification
novel
biomarkers.
Integrating
with
amplifies
diagnostic
capabilities,
opening
avenues
managing
diseases.
This
review
focuses
on
examining
fascinating
interplay
between
theranostics.
Through
highlighting
remarkable
advancements
unique
methodologies,
we
aim
offer
valuable
perspectives
how
approaches
can
bring
about
revolutionary
change
management.
The
objective
is
harness
distinctive
attributes
forge
personalized,
efficient
interventions
disorders,
thereby
providing
beacon
hope
affected
individuals.
In
short,
confluence
heralds
promising
frontier
impactful
treatments
against
diseases,
which
continue
pose
significant
challenges.
By
focusing
personalized
powerful
methods,
might
improve
quality
patients.
Biosensors,
Journal Year:
2024,
Volume and Issue:
14(8), P. 407 - 407
Published: Aug. 22, 2024
Challenges
in
directed
differentiation
and
survival
limit
the
clinical
use
of
stem
cells
despite
their
promising
therapeutic
potential
regenerative
medicine.
Nanotechnology
has
emerged
as
a
powerful
tool
to
address
these
challenges
enable
precise
control
over
cell
fate.
In
particular,
nanomaterials
can
mimic
an
extracellular
matrix
provide
specific
cues
guide
proliferation
field
nanotechnology.
For
instance,
recent
studies
have
demonstrated
that
nanostructured
surfaces
scaffolds
enhance
lineage
commitment
modulated
by
intracellular
regulation
external
stimulation,
such
reactive
oxygen
species
(ROS)
scavenging,
autophagy,
or
electrical
stimulation.
Furthermore,
nanoframework-based
upconversion
nanoparticles
be
used
deliver
bioactive
molecules,
growth
factors,
genetic
materials
facilitate
tissue
regeneration.
The
increasing
nanostructures
research
led
development
new
approaches.
Therefore,
this
review
provides
overview
advances
for
modulating
differentiation,
including
metal-,
carbon-,
peptide-based
strategies.
addition,
we
highlight
nano-enabled
technologies
applications
therapy
focusing
on
improving
efficiency
therapeutics.
We
believe
will
inspire
researchers
intensify
efforts
deepen
understanding,
thereby
accelerating
modulation,
pharmaceutical
industry,
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
In
this
work,
a
novel
CNT-metal-porous
graphene
hybrid
nano-interdigitated
array
electrochemical
8-well
biosensor
has
been
developed
for
the
successful
early-stage
diagnosis
of
Alzheimer's
disease
from
blood
using
e-ELISA
enzyme
by-product
PAP.
Macromolecular Bioscience,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 30, 2024
Abstract
The
incidence
of
nerve
tissue
injuries,
such
as
peripheral
injury,
spinal
cord
traumatic
brain
and
various
neurodegenerative
diseases
(NDs),
is
continuously
increasing
because
stress,
physical
chemical
trauma,
the
aging
population
worldwide.
Restoration
damaged
nervous
system
challenging
its
structural
functional
complexity
limited
regenerative
ability.
Additionally,
there
no
cure
available
for
NDs
except
medications
that
provide
symptomatic
relief.
Stem
cells
offer
an
alternative
approach
promoting
damage
repair,
but
their
efficacy
by
a
compromised
survival
rate
neurogenesis
process.
To
address
these
challenges,
neural
engineering
has
emerged
promising
strategy
in
which
stem
are
seeded
or
encapsulated
within
suitable
biomaterial
construct,
cell
neurogenesis.
Numerous
biomaterials
utilized
to
create
different
types
constructs
this
purpose.
Researchers
trying
develop
ideal
scaffolds
combine
biomaterials,
cells,
molecules
exactly
mimic
biological
mechanical
properties
achieve
recovery
associated
with
neurological
dysfunction.
This
review
focuses
on
exploring
development
applications
potential
use
diagnosis,
therapy,
regeneration,
treatment
disorders.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13302 - 13302
Published: Dec. 11, 2024
This
review
aims
to
address
the
significant
challenges
of
treating
central
nervous
system
(CNS)
disorders
such
as
neurodegenerative
diseases,
strokes,
spinal
cord
injuries,
and
brain
tumors.
These
are
difficult
manage
due
complexity
disease
mechanisms
protective
blood–brain
barrier
(BBB),
which
restricts
drug
delivery.
Recent
advancements
in
nanoparticle
(NP)
technologies
offer
promising
solutions,
with
potential
applications
delivery,
neuroprotection,
neuroregeneration.
By
examining
current
research,
we
explore
how
NPs
can
cross
BBB,
deliver
medications
directly
targeted
CNS
regions,
enhance
both
diagnostics
treatment.
Key
NP
strategies,
passive
targeting,
receptor-mediated
transport,
stimuli-responsive
systems,
demonstrate
encouraging
results.
Studies
show
that
may
improve
minimize
side
effects,
increase
therapeutic
effectiveness
models
Alzheimer’s,
Parkinson’s,
stroke,
glioblastoma.
thus
represent
a
approach
for
disorder
management,
combining
delivery
diagnostic
capabilities
enable
more
precise
effective
treatments
could
significantly
benefit
patient
outcomes.
